Complete Degradation and Detoxification of Ciprofloxacin by a Micro-/Nanostructured Biogenic Mn Oxide Composite from a Highly Active Mn 2+ -Oxidizing Pseudomonas Strain.

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Title:	Complete Degradation and Detoxification of Ciprofloxacin by a Micro-/Nanostructured Biogenic Mn Oxide Composite from a Highly Active Mn 2+ -Oxidizing Pseudomonas Strain.
Authors:	Li, Li¹ (AUTHOR) lily999wy@126.com, Liu, Jin¹ (AUTHOR) liujinlj1987@163.com, Zeng, Jie¹ (AUTHOR) zjzengjiezj@163.com, Li, Jiaoqing² (AUTHOR) lijiaoqing12@126.com, Liu, Yongxuan¹ (AUTHOR) hzaulyx@webmail.hzau.edu.cn, Sun, Xiaowen¹ (AUTHOR) sunxiaowen525@webmail.hzau.edu.cn, Xu, Liangzheng² (AUTHOR) xlzheng@jyu.edu.cn, Li, Lin¹ (AUTHOR) xlzheng@jyu.edu.cn
Source:	Nanomaterials (2079-4991). Jul2021, Vol. 11 Issue 7, p1660-1660. 1p.
Subjects:	Ciprofloxacin, Pseudomonas, Transmission electron microscopy, High performance liquid chromatography, X-ray microscopy, Scanning electron microscopy
Abstract:	Ciprofloxacin (CIP), as a representative broad-spectrum antibiotic, poses a major threat to human health and the ecological environment as a result of its abuse and emissions. In this study, a highly active Mn2+-oxidizing bacterium, Pseudomonas sp. CCTCC M2014168, was induced to form micro-/nanostructured biogenic Mn oxide (BMO) aggregates through continuous culturing with 1 mmoL−1 Mn2+. Following the characterization of Mn4+ oxides and the micro-/nanostructures by scanning electron microscopy, high-resolution transmission electron microscopy and X-ray diffraction assays, the BMO composites were subjected to CIP degradation and detoxification in laboratory trials. High-performance liquid chromatograph (HPLC) analysis identified that the BMO composites were capable of completely degrading CIP, and HPLC with a mass spectrometer (LC/MS) assays identified three intermediates in the degradation pathway. The reaction temperature, pH and initial ciprofloxacin concentration substantially affected the degradation efficiency of CIP to a certain extent, and the metal ions Mg2+, Cu2+, Ni2+ and Co2+ exerted significant inhibitory effects on CIP degradation. A toxicity test of the degradation products showed that CIP was completely detoxified by degradation. Moreover, the prepared BMO composite exhibited a high capacity for repeated degradation and good performance in continuous degradation cycles, as well as a high capacity to degrade CIP in real natural water. [ABSTRACT FROM AUTHOR]
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Database:	Engineering Source

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Abstract:	Ciprofloxacin (CIP), as a representative broad-spectrum antibiotic, poses a major threat to human health and the ecological environment as a result of its abuse and emissions. In this study, a highly active Mn2+-oxidizing bacterium, Pseudomonas sp. CCTCC M2014168, was induced to form micro-/nanostructured biogenic Mn oxide (BMO) aggregates through continuous culturing with 1 mmoL−1 Mn2+. Following the characterization of Mn4+ oxides and the micro-/nanostructures by scanning electron microscopy, high-resolution transmission electron microscopy and X-ray diffraction assays, the BMO composites were subjected to CIP degradation and detoxification in laboratory trials. High-performance liquid chromatograph (HPLC) analysis identified that the BMO composites were capable of completely degrading CIP, and HPLC with a mass spectrometer (LC/MS) assays identified three intermediates in the degradation pathway. The reaction temperature, pH and initial ciprofloxacin concentration substantially affected the degradation efficiency of CIP to a certain extent, and the metal ions Mg2+, Cu2+, Ni2+ and Co2+ exerted significant inhibitory effects on CIP degradation. A toxicity test of the degradation products showed that CIP was completely detoxified by degradation. Moreover, the prepared BMO composite exhibited a high capacity for repeated degradation and good performance in continuous degradation cycles, as well as a high capacity to degrade CIP in real natural water. [ABSTRACT FROM AUTHOR]
ISSN:	20794991
DOI:	10.3390/nano11071660