The effects of an initial depolarization pulse on dissolved phase hyperpolarized 129Xe brain MRI.

Saved in:

Bibliographic Details
Title:	The effects of an initial depolarization pulse on dissolved phase hyperpolarized ¹²⁹Xe brain MRI.
Authors:	Shepelytskyi, Yurii^1,2 (AUTHOR), Grynko, Vira^2,3 (AUTHOR), Li, Tao¹ (AUTHOR), Hassan, Ayman^4,5 (AUTHOR), Granberg, Karl⁴ (AUTHOR), Albert, Mitchell S.^1,2,5 (AUTHOR) malbert1@lakeheadu.ca
Source:	Magnetic Resonance in Medicine. Dec2021, Vol. 86 Issue 6, p3147-3155. 9p.
Subjects:	Magnetic resonance imaging, Brain imaging, Scanning systems
Abstract:	Purpose: To evaluate the effect of an initial 90° depolarization RF pulse on the dissolved‐phase hyperpolarized (HP) xenon‐129 (129Xe) brain imaging and to compare the SNR variability of HP 129Xe images acquired without an initial depolarization RF pulse to those following the initial depolarization pulse. Methods: Five cognitive normal healthy volunteers were imaged using a Philips Achieva 3.0T MRI scanner during a single breath‐hold following inhalation of 1 L of HP 129Xe. Each participant underwent six HP 129Xe scans. Three scans were performed using conventional single‐slice projection HP 129Xe brain imaging, and the other three scans were performed using the HP 129Xe time‐of‐flight imaging with an initial rectangular depolarization pulse. Results: Although the utilization of an initial depolarization results in the reduction of the mean image SNR, the presence of an initial depolarization RF pulse reduces the SNR variability of the HP 129Xe brain image by a factor of 2.26. The highest SNR variability was observed from the posterior brain region, where the anterior region possessed the lower level of signal variability. Conclusion: An initial 90° depolarization RF pulse, applied prior to the HP 129Xe image acquisition, reduced the HP 129Xe signal variability more than two times between the different breath‐hold images. [ABSTRACT FROM AUTHOR]
	Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database:	Engineering Source

Description
Abstract:	Purpose: To evaluate the effect of an initial 90° depolarization RF pulse on the dissolved‐phase hyperpolarized (HP) xenon‐129 (129Xe) brain imaging and to compare the SNR variability of HP 129Xe images acquired without an initial depolarization RF pulse to those following the initial depolarization pulse. Methods: Five cognitive normal healthy volunteers were imaged using a Philips Achieva 3.0T MRI scanner during a single breath‐hold following inhalation of 1 L of HP 129Xe. Each participant underwent six HP 129Xe scans. Three scans were performed using conventional single‐slice projection HP 129Xe brain imaging, and the other three scans were performed using the HP 129Xe time‐of‐flight imaging with an initial rectangular depolarization pulse. Results: Although the utilization of an initial depolarization results in the reduction of the mean image SNR, the presence of an initial depolarization RF pulse reduces the SNR variability of the HP 129Xe brain image by a factor of 2.26. The highest SNR variability was observed from the posterior brain region, where the anterior region possessed the lower level of signal variability. Conclusion: An initial 90° depolarization RF pulse, applied prior to the HP 129Xe image acquisition, reduced the HP 129Xe signal variability more than two times between the different breath‐hold images. [ABSTRACT FROM AUTHOR]
ISSN:	07403194
DOI:	10.1002/mrm.28918