Hyperpolarized 129Xe multi‐slice imaging of the human brain using a 3D gradient echo pulse sequence.

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Bibliographic Details
Title:	Hyperpolarized ¹²⁹Xe multi‐slice imaging of the human brain using a 3D gradient echo pulse sequence.
Authors:	Grynko, Vira^1,2 (AUTHOR), Shepelytskyi, Yurii^2,3 (AUTHOR), Li, Tao³ (AUTHOR), Hassan, Ayman^4,5 (AUTHOR), Granberg, Karl⁴ (AUTHOR), Albert, Mitchell S.^2,3,5 (AUTHOR) malbert1@lakeheadu.ca
Source:	Magnetic Resonance in Medicine. Dec2021, Vol. 86 Issue 6, p3175-3181. 7p.
Subjects:	Magnetic resonance imaging, Brain imaging, Gray matter (Nerve tissue), Signal-to-noise ratio
Geographic Terms:	Andover (Mass.)
Abstract:	Purpose: To demonstrate the possibility of performing multi‐slice in‐vivo human brain MRI using hyperpolarized (HP) xenon‐129 (129Xe) in two different orientations and to calculate the signal‐to‐noise ratio (SNR). Methods: Two healthy female participants were imaged during a single breath‐hold of HP 129Xe using a Philips Achieva 3.0T MRI scanner (Philips, Andover, MA). Each HP 129Xe multi‐slice brain image was acquired during separate HP 129Xe breath‐holds using 3D gradient echo (GRE) imaging. The acquisition started 10 s after the inhalation of 1 L of HP 129Xe. Overall, four sagittal and three axial images were acquired (seven imaging sessions per participant). The SNR was calculated for each slice in both orientations. Results: The first ever HP 129Xe multi‐slice images of the brain were acquired in axial and sagittal orientations. The HP 129Xe signal distribution correlated well with the gray matter distribution. The highest SNR values were close in the axial and sagittal orientations (19.46 ± 3.25 and 18.76 ± 4.94, respectively). Additionally, anatomical features, such as the ventricles, were observed in both orientations. Conclusion: The possibility of using multi‐slice HP 129Xe human brain magnetic resonance imaging was demonstrated for the first time. HP 129Xe multi‐slice MRI can be implemented for brain imaging to improve current diagnostic methods. [ABSTRACT FROM AUTHOR]
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Database:	Engineering Source

Description
Abstract:	Purpose: To demonstrate the possibility of performing multi‐slice in‐vivo human brain MRI using hyperpolarized (HP) xenon‐129 (129Xe) in two different orientations and to calculate the signal‐to‐noise ratio (SNR). Methods: Two healthy female participants were imaged during a single breath‐hold of HP 129Xe using a Philips Achieva 3.0T MRI scanner (Philips, Andover, MA). Each HP 129Xe multi‐slice brain image was acquired during separate HP 129Xe breath‐holds using 3D gradient echo (GRE) imaging. The acquisition started 10 s after the inhalation of 1 L of HP 129Xe. Overall, four sagittal and three axial images were acquired (seven imaging sessions per participant). The SNR was calculated for each slice in both orientations. Results: The first ever HP 129Xe multi‐slice images of the brain were acquired in axial and sagittal orientations. The HP 129Xe signal distribution correlated well with the gray matter distribution. The highest SNR values were close in the axial and sagittal orientations (19.46 ± 3.25 and 18.76 ± 4.94, respectively). Additionally, anatomical features, such as the ventricles, were observed in both orientations. Conclusion: The possibility of using multi‐slice HP 129Xe human brain magnetic resonance imaging was demonstrated for the first time. HP 129Xe multi‐slice MRI can be implemented for brain imaging to improve current diagnostic methods. [ABSTRACT FROM AUTHOR]
ISSN:	07403194
DOI:	10.1002/mrm.28932