Prenylated C6–C3 derivatives from the stems and branches of Illicium ternstroemioides A. C. Smith with antiviral activity.
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| Title: | Prenylated C6–C3 derivatives from the stems and branches of Illicium ternstroemioides A. C. Smith with antiviral activity. |
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| Authors: | Zhang, Jian-Pei1 (AUTHOR), Li, Wen-Rui1 (AUTHOR), Wu, Shuo2 (AUTHOR), Wang, Xiao-Jing1 (AUTHOR), Wang, Ru-Bing1 (AUTHOR), Li, Mi1 (AUTHOR), Su, Guo-Zhu1 (AUTHOR), Wang, Hai-Qiang1 (AUTHOR), Yong, Jin-Yao1 (AUTHOR), Yang, Jia1 (AUTHOR), Li, Li1 (AUTHOR), Li, Yu-Huan1,2 (AUTHOR) yuhuanlibj@126.com, Ma, Shuang-Gang1 (AUTHOR) mashuanggang@imm.ac.cn |
| Source: | Phytochemistry. Dec2021, Vol. 192, pN.PAG-N.PAG. 1p. |
| Subjects: | Influenza A virus, Influenza viruses, Coxsackieviruses, X-ray crystallography |
| Abstract: | Thirteen compounds were isolated from the lipid-soluble extracts of Illicium ternstroemioides A. C. Smith, including eleven previously undescribed prenylated C 6 –C 3 compounds, a previously undescribed prenylated C 6 –C 3 derivative-abscisic acid ester hybrid, and a known compound (4 S)-illicinone I. Their structures and configurations were mainly elucidated by spectroscopic analyses, CD experiments and X-ray crystallography. (2 S ,4 R ,11 S)-4- O -methyl-12-chloroillifunone C, (2 S ,4 R ,11 R)-2,3-dihydro-4- O -methyl illioliganfunone D, and illiternfunol A were found to exhibit weak activity against Coxsackievirus B3, with IC 50 values ranging from 27.8 to 33.3 μM. Illiternone B exhibited more potent activities against Coxsackievirus B3 and influenza virus A than did its geometric isomer illiternone A, with IC 50 values of 7.7 μM and 2.5 μM, respectively. None of these compounds displayed cytotoxic activities. Twelve undescribed prenylated C 6 –C 3 derivatives were isolated from Illicium ternstroemioides A. C. Smith. Illiternfunone A (10) represents the first example of prenylated C 6 –C 3 derivative-abscisic acid ester hybrid. Illiternone B (12) was found to exhibit potent activities against Coxsackie virus B3 and influenza virus A. [Display omitted] • Thirteen undescribed prenylated C 6 –C 3 derivatives were isolated from Illicium ternstroemioides A. C. Smith. • Illiternone B was found to exhibit potent activities against coxsackie virus B3 and influenza virus A. • Illiternfunone A represents the first example of prenylated C 6 –C 3 derivative-abscisic acid ester hybrid. [ABSTRACT FROM AUTHOR] |
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| Database: | Engineering Source |
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