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Metabolic systems biology and multi-omics of cyanobacteria: Perspectives and future directions.

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Title: Metabolic systems biology and multi-omics of cyanobacteria: Perspectives and future directions.
Authors: Pathania, Ruchi1 (AUTHOR), Srivastava, Amit1,2 (AUTHOR), Srivastava, Shireesh1,3 (AUTHOR), Shukla, Pratyoosh1,4,5 (AUTHOR) pratyoosh.shukla@gmail.com
Source: Bioresource Technology. Jan2022, Vol. 343, pN.PAG-N.PAG. 1p.
Subjects: Systems biology, Atmospheric carbon dioxide, Metabolomics, Metabolic flux analysis, Metabolic models, Genetic regulation, Synthetic biology
Abstract: [Display omitted] • Various techniques for understanding cyanobacterial metabolism are reviewed here. • Integration of multi-omics data with metabolic models are discussed. • Various applications of metabolic systems biology and multi-omics are presented. Cyanobacteria are oxygenic photoautotrophs whose metabolism contains key biochemical pathways to fix atmospheric CO 2 and synthesize various metabolites. The development of bioengineering tools has enabled the manipulation of cyanobacterial chassis to produce various valuable bioproducts photosynthetically. However, effective utilization of cyanobacteria as photosynthetic cell factories needs a detailed understanding of their metabolism and its interaction with other cellular processes. Implementing systems and synthetic biology tools has generated a wealth of information on various metabolic pathways. However, to design effective engineering strategies for further improvement in growth, photosynthetic efficiency, and enhanced production of target biochemicals, in-depth knowledge of their carbon/nitrogen metabolism, pathway fluxe distribution, genetic regulation and integrative analyses are necessary. In this review, we discuss the recent advances in the development of genome-scale metabolic models (GSMMs), omics analyses (metabolomics, transcriptomics, proteomics, fluxomics), and integrative modeling approaches to showcase the current understanding of cyanobacterial metabolism. [ABSTRACT FROM AUTHOR]
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Database: Engineering Source
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Abstract:[Display omitted] • Various techniques for understanding cyanobacterial metabolism are reviewed here. • Integration of multi-omics data with metabolic models are discussed. • Various applications of metabolic systems biology and multi-omics are presented. Cyanobacteria are oxygenic photoautotrophs whose metabolism contains key biochemical pathways to fix atmospheric CO 2 and synthesize various metabolites. The development of bioengineering tools has enabled the manipulation of cyanobacterial chassis to produce various valuable bioproducts photosynthetically. However, effective utilization of cyanobacteria as photosynthetic cell factories needs a detailed understanding of their metabolism and its interaction with other cellular processes. Implementing systems and synthetic biology tools has generated a wealth of information on various metabolic pathways. However, to design effective engineering strategies for further improvement in growth, photosynthetic efficiency, and enhanced production of target biochemicals, in-depth knowledge of their carbon/nitrogen metabolism, pathway fluxe distribution, genetic regulation and integrative analyses are necessary. In this review, we discuss the recent advances in the development of genome-scale metabolic models (GSMMs), omics analyses (metabolomics, transcriptomics, proteomics, fluxomics), and integrative modeling approaches to showcase the current understanding of cyanobacterial metabolism. [ABSTRACT FROM AUTHOR]
ISSN:09608524
DOI:10.1016/j.biortech.2021.126007