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Magnetic implants in vivo guiding sorafenib liver delivery by superparamagnetic solid lipid nanoparticles.

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Title: Magnetic implants in vivo guiding sorafenib liver delivery by superparamagnetic solid lipid nanoparticles.
Authors: Iacobazzi, Rosa Maria1 (AUTHOR) r.m.iacobazzi@oncologico.bari.it, Vischio, Fabio1,2,3 (AUTHOR) fabio.vischio@uniba.it, Arduino, Ilaria4 (AUTHOR) ilaria.arduino@uniba.it, Canepa, Fabio5 (AUTHOR) Fabio.Canepa@unige.it, Laquintana, Valentino4 (AUTHOR) valentino.laquintana@uniba.it, Notarnicola, Maria6 (AUTHOR) maria.notarnicola@irccsdebellis.it, Scavo, Maria Principia6 (AUTHOR) maria.scavo@irccsdebellis.it, Bianco, Giusy6 (AUTHOR) giusi.bianco@irccsdebellis.it, Fanizza, Elisabetta2,3 (AUTHOR) elisabetta.fanizza@uniba.it, Lopedota, Angela Assunta4 (AUTHOR) angelaassunta.lopedota@uniba.it, Cutrignelli, Annalisa4 (AUTHOR) annalisa.cutrignelli@uniba.it, Lopalco, Antonio4 (AUTHOR) antonio.lopalco@uniba.it, Azzariti, Amalia1 (AUTHOR) a.azzariti@oncologico.bari.it, Curri, Maria Lucia2,3 (AUTHOR) marialucia.curri@uniba.it, Franco, Massimo4 (AUTHOR) massimo.franco@uniba.it, Giannelli, Gianluigi7 (AUTHOR) gianluigi.giannelli@irccsdebellis.it, Lee, Byung Chul8 (AUTHOR) leebc@snu.ac.kr, Depalo, Nicoletta1,3 (AUTHOR) n.depalo@ba.ipcf.cnr.it, Denora, Nunzio1,4 (AUTHOR) nunzio.denora@uniba.it
Source: Journal of Colloid & Interface Science. Feb2022:Part 1, Vol. 608, p239-254. 16p.
Subjects: Iron oxide nanoparticles, Magnetic field effects, Contrast media, Sorafenib, Electromagnetic induction, Liver
Abstract: [Display omitted] Solid lipid nanoparticles (SLNs), co-encapsulating superparamagnetic iron oxide nanoparticles and sorafenib, have been exploited for magnetic-guided drug delivery to the liver. Two different magnetic configurations, both comprising two small magnets, were under-skin implanted to investigate the effect of the magnetic field topology on the magnetic SLNP accumulation in liver tissues. A preliminary simulation analysis was performed to predict the magnetic field topography for each tested configuration. SLNs were prepared using a hot homogenization approach and characterized using complementary techniques. Their in vitro biological behavior was assessed in HepG-2 liver cancer cells; wild-type mice were used for the in vivo study. The magnet configuration that resulted in a higher magnetic targeting efficiency was investigated by evaluating the iron content in homogenated murine liver tissues. SLNs, characterized by an average size smaller than 200 nm, retained their superparamagnetic behavior and relevant molecular resonance imaging properties as negative contrast agents. The evaluation of iron accumulation in the liver tissues was consistent with the magnetic induction profile of each magnet configuration, concurring with the results predicted by simulation analysis and obtained by measurements in living mice. [ABSTRACT FROM AUTHOR]
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Database: Engineering Source
Description
Abstract:[Display omitted] Solid lipid nanoparticles (SLNs), co-encapsulating superparamagnetic iron oxide nanoparticles and sorafenib, have been exploited for magnetic-guided drug delivery to the liver. Two different magnetic configurations, both comprising two small magnets, were under-skin implanted to investigate the effect of the magnetic field topology on the magnetic SLNP accumulation in liver tissues. A preliminary simulation analysis was performed to predict the magnetic field topography for each tested configuration. SLNs were prepared using a hot homogenization approach and characterized using complementary techniques. Their in vitro biological behavior was assessed in HepG-2 liver cancer cells; wild-type mice were used for the in vivo study. The magnet configuration that resulted in a higher magnetic targeting efficiency was investigated by evaluating the iron content in homogenated murine liver tissues. SLNs, characterized by an average size smaller than 200 nm, retained their superparamagnetic behavior and relevant molecular resonance imaging properties as negative contrast agents. The evaluation of iron accumulation in the liver tissues was consistent with the magnetic induction profile of each magnet configuration, concurring with the results predicted by simulation analysis and obtained by measurements in living mice. [ABSTRACT FROM AUTHOR]
ISSN:00219797
DOI:10.1016/j.jcis.2021.09.174