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Magnetic implants in vivo guiding sorafenib liver delivery by superparamagnetic solid lipid nanoparticles.

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Title: Magnetic implants in vivo guiding sorafenib liver delivery by superparamagnetic solid lipid nanoparticles.
Authors: Iacobazzi, Rosa Maria1 (AUTHOR) r.m.iacobazzi@oncologico.bari.it, Vischio, Fabio1,2,3 (AUTHOR) fabio.vischio@uniba.it, Arduino, Ilaria4 (AUTHOR) ilaria.arduino@uniba.it, Canepa, Fabio5 (AUTHOR) Fabio.Canepa@unige.it, Laquintana, Valentino4 (AUTHOR) valentino.laquintana@uniba.it, Notarnicola, Maria6 (AUTHOR) maria.notarnicola@irccsdebellis.it, Scavo, Maria Principia6 (AUTHOR) maria.scavo@irccsdebellis.it, Bianco, Giusy6 (AUTHOR) giusi.bianco@irccsdebellis.it, Fanizza, Elisabetta2,3 (AUTHOR) elisabetta.fanizza@uniba.it, Lopedota, Angela Assunta4 (AUTHOR) angelaassunta.lopedota@uniba.it, Cutrignelli, Annalisa4 (AUTHOR) annalisa.cutrignelli@uniba.it, Lopalco, Antonio4 (AUTHOR) antonio.lopalco@uniba.it, Azzariti, Amalia1 (AUTHOR) a.azzariti@oncologico.bari.it, Curri, Maria Lucia2,3 (AUTHOR) marialucia.curri@uniba.it, Franco, Massimo4 (AUTHOR) massimo.franco@uniba.it, Giannelli, Gianluigi7 (AUTHOR) gianluigi.giannelli@irccsdebellis.it, Lee, Byung Chul8 (AUTHOR) leebc@snu.ac.kr, Depalo, Nicoletta1,3 (AUTHOR) n.depalo@ba.ipcf.cnr.it, Denora, Nunzio1,4 (AUTHOR) nunzio.denora@uniba.it
Source: Journal of Colloid & Interface Science. Feb2022:Part 1, Vol. 608, p239-254. 16p.
Subjects: Iron oxide nanoparticles, Magnetic field effects, Contrast media, Sorafenib, Electromagnetic induction, Liver
Abstract: [Display omitted] Solid lipid nanoparticles (SLNs), co-encapsulating superparamagnetic iron oxide nanoparticles and sorafenib, have been exploited for magnetic-guided drug delivery to the liver. Two different magnetic configurations, both comprising two small magnets, were under-skin implanted to investigate the effect of the magnetic field topology on the magnetic SLNP accumulation in liver tissues. A preliminary simulation analysis was performed to predict the magnetic field topography for each tested configuration. SLNs were prepared using a hot homogenization approach and characterized using complementary techniques. Their in vitro biological behavior was assessed in HepG-2 liver cancer cells; wild-type mice were used for the in vivo study. The magnet configuration that resulted in a higher magnetic targeting efficiency was investigated by evaluating the iron content in homogenated murine liver tissues. SLNs, characterized by an average size smaller than 200 nm, retained their superparamagnetic behavior and relevant molecular resonance imaging properties as negative contrast agents. The evaluation of iron accumulation in the liver tissues was consistent with the magnetic induction profile of each magnet configuration, concurring with the results predicted by simulation analysis and obtained by measurements in living mice. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Colloid & Interface Science is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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Header DbId: egs
DbLabel: Engineering Source
An: 153868573
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Data: Magnetic implants in vivo guiding sorafenib liver delivery by superparamagnetic solid lipid nanoparticles.
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  Data: <searchLink fieldCode="AR" term="%22Iacobazzi%2C+Rosa+Maria%22">Iacobazzi, Rosa Maria</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> r.m.iacobazzi@oncologico.bari.it</i><br /><searchLink fieldCode="AR" term="%22Vischio%2C+Fabio%22">Vischio, Fabio</searchLink><relatesTo>1,2,3</relatesTo> (AUTHOR)<i> fabio.vischio@uniba.it</i><br /><searchLink fieldCode="AR" term="%22Arduino%2C+Ilaria%22">Arduino, Ilaria</searchLink><relatesTo>4</relatesTo> (AUTHOR)<i> ilaria.arduino@uniba.it</i><br /><searchLink fieldCode="AR" term="%22Canepa%2C+Fabio%22">Canepa, Fabio</searchLink><relatesTo>5</relatesTo> (AUTHOR)<i> Fabio.Canepa@unige.it</i><br /><searchLink fieldCode="AR" term="%22Laquintana%2C+Valentino%22">Laquintana, Valentino</searchLink><relatesTo>4</relatesTo> (AUTHOR)<i> valentino.laquintana@uniba.it</i><br /><searchLink fieldCode="AR" term="%22Notarnicola%2C+Maria%22">Notarnicola, Maria</searchLink><relatesTo>6</relatesTo> (AUTHOR)<i> maria.notarnicola@irccsdebellis.it</i><br /><searchLink fieldCode="AR" term="%22Scavo%2C+Maria+Principia%22">Scavo, Maria Principia</searchLink><relatesTo>6</relatesTo> (AUTHOR)<i> maria.scavo@irccsdebellis.it</i><br /><searchLink fieldCode="AR" term="%22Bianco%2C+Giusy%22">Bianco, Giusy</searchLink><relatesTo>6</relatesTo> (AUTHOR)<i> giusi.bianco@irccsdebellis.it</i><br /><searchLink fieldCode="AR" term="%22Fanizza%2C+Elisabetta%22">Fanizza, Elisabetta</searchLink><relatesTo>2,3</relatesTo> (AUTHOR)<i> elisabetta.fanizza@uniba.it</i><br /><searchLink fieldCode="AR" term="%22Lopedota%2C+Angela+Assunta%22">Lopedota, Angela Assunta</searchLink><relatesTo>4</relatesTo> (AUTHOR)<i> angelaassunta.lopedota@uniba.it</i><br /><searchLink fieldCode="AR" term="%22Cutrignelli%2C+Annalisa%22">Cutrignelli, Annalisa</searchLink><relatesTo>4</relatesTo> (AUTHOR)<i> annalisa.cutrignelli@uniba.it</i><br /><searchLink fieldCode="AR" term="%22Lopalco%2C+Antonio%22">Lopalco, Antonio</searchLink><relatesTo>4</relatesTo> (AUTHOR)<i> antonio.lopalco@uniba.it</i><br /><searchLink fieldCode="AR" term="%22Azzariti%2C+Amalia%22">Azzariti, Amalia</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> a.azzariti@oncologico.bari.it</i><br /><searchLink fieldCode="AR" term="%22Curri%2C+Maria+Lucia%22">Curri, Maria Lucia</searchLink><relatesTo>2,3</relatesTo> (AUTHOR)<i> marialucia.curri@uniba.it</i><br /><searchLink fieldCode="AR" term="%22Franco%2C+Massimo%22">Franco, Massimo</searchLink><relatesTo>4</relatesTo> (AUTHOR)<i> massimo.franco@uniba.it</i><br /><searchLink fieldCode="AR" term="%22Giannelli%2C+Gianluigi%22">Giannelli, Gianluigi</searchLink><relatesTo>7</relatesTo> (AUTHOR)<i> gianluigi.giannelli@irccsdebellis.it</i><br /><searchLink fieldCode="AR" term="%22Lee%2C+Byung+Chul%22">Lee, Byung Chul</searchLink><relatesTo>8</relatesTo> (AUTHOR)<i> leebc@snu.ac.kr</i><br /><searchLink fieldCode="AR" term="%22Depalo%2C+Nicoletta%22">Depalo, Nicoletta</searchLink><relatesTo>1,3</relatesTo> (AUTHOR)<i> n.depalo@ba.ipcf.cnr.it</i><br /><searchLink fieldCode="AR" term="%22Denora%2C+Nunzio%22">Denora, Nunzio</searchLink><relatesTo>1,4</relatesTo> (AUTHOR)<i> nunzio.denora@uniba.it</i>
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Colloid+%26+Interface+Science%22">Journal of Colloid & Interface Science</searchLink>. Feb2022:Part 1, Vol. 608, p239-254. 16p.
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  Data: <searchLink fieldCode="DE" term="%22Iron+oxide+nanoparticles%22">Iron oxide nanoparticles</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetic+field+effects%22">Magnetic field effects</searchLink><br /><searchLink fieldCode="DE" term="%22Contrast+media%22">Contrast media</searchLink><br /><searchLink fieldCode="DE" term="%22Sorafenib%22">Sorafenib</searchLink><br /><searchLink fieldCode="DE" term="%22Electromagnetic+induction%22">Electromagnetic induction</searchLink><br /><searchLink fieldCode="DE" term="%22Liver%22">Liver</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: [Display omitted] Solid lipid nanoparticles (SLNs), co-encapsulating superparamagnetic iron oxide nanoparticles and sorafenib, have been exploited for magnetic-guided drug delivery to the liver. Two different magnetic configurations, both comprising two small magnets, were under-skin implanted to investigate the effect of the magnetic field topology on the magnetic SLNP accumulation in liver tissues. A preliminary simulation analysis was performed to predict the magnetic field topography for each tested configuration. SLNs were prepared using a hot homogenization approach and characterized using complementary techniques. Their in vitro biological behavior was assessed in HepG-2 liver cancer cells; wild-type mice were used for the in vivo study. The magnet configuration that resulted in a higher magnetic targeting efficiency was investigated by evaluating the iron content in homogenated murine liver tissues. SLNs, characterized by an average size smaller than 200 nm, retained their superparamagnetic behavior and relevant molecular resonance imaging properties as negative contrast agents. The evaluation of iron accumulation in the liver tissues was consistent with the magnetic induction profile of each magnet configuration, concurring with the results predicted by simulation analysis and obtained by measurements in living mice. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of Journal of Colloid & Interface Science is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=153868573
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      – Type: doi
        Value: 10.1016/j.jcis.2021.09.174
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      – Code: eng
        Text: English
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        PageCount: 16
        StartPage: 239
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      – SubjectFull: Iron oxide nanoparticles
        Type: general
      – SubjectFull: Magnetic field effects
        Type: general
      – SubjectFull: Contrast media
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      – SubjectFull: Sorafenib
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      – SubjectFull: Electromagnetic induction
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      – SubjectFull: Liver
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              Text: Feb2022:Part 1
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