Synthesis and Characterization of Tetracycline Loaded Methionine-Coated NiFe 2 O 4 Nanoparticles for Anticancer and Antibacterial Applications.
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| Title: | Synthesis and Characterization of Tetracycline Loaded Methionine-Coated NiFe 2 O 4 Nanoparticles for Anticancer and Antibacterial Applications. |
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| Authors: | Yeganeh, Faten Eshrati1 (AUTHOR) ffyeganeh@gmail.com, Yeganeh, Amir Eshrati2 (AUTHOR) amireshratiyegane@gmail.com, Far, Bahareh Farasati3 (AUTHOR) bahar.ferasati@gmail.com, Mansouri, Afsoun4 (AUTHOR) afsoonmansori@yahoo.com, Sibuh, Belay Zeleke5 (AUTHOR) belayzeleke63@yahoo.com, Krishnan, Saravanan6 (AUTHOR) sara.krish87@gmail.com, Pandit, Soumya7 (AUTHOR) sounip@gmail.com, Alsanie, Walaa F.8 (AUTHOR) w.alsanie@tu.edu.sa, Thakur, Vijay Kumar9,10,11 (AUTHOR) vijay.thakur@sruc.ac.uk, Gupta, Piyush Kumar7,12 (AUTHOR) vijay.thakur@sruc.ac.uk |
| Source: | Nanomaterials (2079-4991). Jul2022, Vol. 12 Issue 13, p2286-N.PAG. 15p. |
| Subjects: | Controlled release drugs, Magnetic nanoparticles, Nanostructured materials, Magnetic materials, Nanoparticles, Smart materials, Ferrites |
| Abstract: | In the present study, nickel ferrite (NiFe2O4)-based smart magnetic nanoparticles were fabricated and coated with methionine. Physiochemical characterization of the obtained Met-NiFe2O4 nanoparticles revealed the presence of methionine coating over the nanoparticle surface. Drug release study indicated that Tet-Met-NiFe2O4 nanoparticles possess pH-responsive controlled drug release behavior for tetracycline (Tet). The drug loading content for Tet was found to be 0.27 mg/L of nanoparticles. In vitro cytotoxicity test showed that the Met-NiFe2O4 nanoparticles is biocompatible. Moreover, this magnetic nanostructured material shown strong anticancer property as these nanomaterials significantly reduced the viability of A375 cells when compared to free Tet solution. In addition, Tet-Met-NiFe2O4 nanoparticles also showed strong antibacterial activity against different bacterial pathogens. [ABSTRACT FROM AUTHOR] |
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| Database: | Engineering Source |
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| Abstract: | In the present study, nickel ferrite (NiFe2O4)-based smart magnetic nanoparticles were fabricated and coated with methionine. Physiochemical characterization of the obtained Met-NiFe2O4 nanoparticles revealed the presence of methionine coating over the nanoparticle surface. Drug release study indicated that Tet-Met-NiFe2O4 nanoparticles possess pH-responsive controlled drug release behavior for tetracycline (Tet). The drug loading content for Tet was found to be 0.27 mg/L of nanoparticles. In vitro cytotoxicity test showed that the Met-NiFe2O4 nanoparticles is biocompatible. Moreover, this magnetic nanostructured material shown strong anticancer property as these nanomaterials significantly reduced the viability of A375 cells when compared to free Tet solution. In addition, Tet-Met-NiFe2O4 nanoparticles also showed strong antibacterial activity against different bacterial pathogens. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 20794991 |
| DOI: | 10.3390/nano12132286 |
