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Synthesis and Characterization of Tetracycline Loaded Methionine-Coated NiFe 2 O 4 Nanoparticles for Anticancer and Antibacterial Applications.

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Title: Synthesis and Characterization of Tetracycline Loaded Methionine-Coated NiFe 2 O 4 Nanoparticles for Anticancer and Antibacterial Applications.
Authors: Yeganeh, Faten Eshrati1 (AUTHOR) ffyeganeh@gmail.com, Yeganeh, Amir Eshrati2 (AUTHOR) amireshratiyegane@gmail.com, Far, Bahareh Farasati3 (AUTHOR) bahar.ferasati@gmail.com, Mansouri, Afsoun4 (AUTHOR) afsoonmansori@yahoo.com, Sibuh, Belay Zeleke5 (AUTHOR) belayzeleke63@yahoo.com, Krishnan, Saravanan6 (AUTHOR) sara.krish87@gmail.com, Pandit, Soumya7 (AUTHOR) sounip@gmail.com, Alsanie, Walaa F.8 (AUTHOR) w.alsanie@tu.edu.sa, Thakur, Vijay Kumar9,10,11 (AUTHOR) vijay.thakur@sruc.ac.uk, Gupta, Piyush Kumar7,12 (AUTHOR) vijay.thakur@sruc.ac.uk
Source: Nanomaterials (2079-4991). Jul2022, Vol. 12 Issue 13, p2286-N.PAG. 15p.
Subjects: Controlled release drugs, Magnetic nanoparticles, Nanostructured materials, Magnetic materials, Nanoparticles, Smart materials, Ferrites
Abstract: In the present study, nickel ferrite (NiFe2O4)-based smart magnetic nanoparticles were fabricated and coated with methionine. Physiochemical characterization of the obtained Met-NiFe2O4 nanoparticles revealed the presence of methionine coating over the nanoparticle surface. Drug release study indicated that Tet-Met-NiFe2O4 nanoparticles possess pH-responsive controlled drug release behavior for tetracycline (Tet). The drug loading content for Tet was found to be 0.27 mg/L of nanoparticles. In vitro cytotoxicity test showed that the Met-NiFe2O4 nanoparticles is biocompatible. Moreover, this magnetic nanostructured material shown strong anticancer property as these nanomaterials significantly reduced the viability of A375 cells when compared to free Tet solution. In addition, Tet-Met-NiFe2O4 nanoparticles also showed strong antibacterial activity against different bacterial pathogens. [ABSTRACT FROM AUTHOR]
Copyright of Nanomaterials (2079-4991) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Synthesis and Characterization of Tetracycline Loaded Methionine-Coated NiFe 2 O 4 Nanoparticles for Anticancer and Antibacterial Applications.
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  Data: <searchLink fieldCode="AR" term="%22Yeganeh%2C+Faten+Eshrati%22">Yeganeh, Faten Eshrati</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> ffyeganeh@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Yeganeh%2C+Amir+Eshrati%22">Yeganeh, Amir Eshrati</searchLink><relatesTo>2</relatesTo> (AUTHOR)<i> amireshratiyegane@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Far%2C+Bahareh+Farasati%22">Far, Bahareh Farasati</searchLink><relatesTo>3</relatesTo> (AUTHOR)<i> bahar.ferasati@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Mansouri%2C+Afsoun%22">Mansouri, Afsoun</searchLink><relatesTo>4</relatesTo> (AUTHOR)<i> afsoonmansori@yahoo.com</i><br /><searchLink fieldCode="AR" term="%22Sibuh%2C+Belay+Zeleke%22">Sibuh, Belay Zeleke</searchLink><relatesTo>5</relatesTo> (AUTHOR)<i> belayzeleke63@yahoo.com</i><br /><searchLink fieldCode="AR" term="%22Krishnan%2C+Saravanan%22">Krishnan, Saravanan</searchLink><relatesTo>6</relatesTo> (AUTHOR)<i> sara.krish87@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Pandit%2C+Soumya%22">Pandit, Soumya</searchLink><relatesTo>7</relatesTo> (AUTHOR)<i> sounip@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Alsanie%2C+Walaa+F%2E%22">Alsanie, Walaa F.</searchLink><relatesTo>8</relatesTo> (AUTHOR)<i> w.alsanie@tu.edu.sa</i><br /><searchLink fieldCode="AR" term="%22Thakur%2C+Vijay+Kumar%22">Thakur, Vijay Kumar</searchLink><relatesTo>9,10,11</relatesTo> (AUTHOR)<i> vijay.thakur@sruc.ac.uk</i><br /><searchLink fieldCode="AR" term="%22Gupta%2C+Piyush+Kumar%22">Gupta, Piyush Kumar</searchLink><relatesTo>7,12</relatesTo> (AUTHOR)<i> vijay.thakur@sruc.ac.uk</i>
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  Data: <searchLink fieldCode="JN" term="%22Nanomaterials+%282079-4991%29%22">Nanomaterials (2079-4991)</searchLink>. Jul2022, Vol. 12 Issue 13, p2286-N.PAG. 15p.
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  Data: <searchLink fieldCode="DE" term="%22Controlled+release+drugs%22">Controlled release drugs</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetic+nanoparticles%22">Magnetic nanoparticles</searchLink><br /><searchLink fieldCode="DE" term="%22Nanostructured+materials%22">Nanostructured materials</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetic+materials%22">Magnetic materials</searchLink><br /><searchLink fieldCode="DE" term="%22Nanoparticles%22">Nanoparticles</searchLink><br /><searchLink fieldCode="DE" term="%22Smart+materials%22">Smart materials</searchLink><br /><searchLink fieldCode="DE" term="%22Ferrites%22">Ferrites</searchLink>
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  Label: Abstract
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  Data: In the present study, nickel ferrite (NiFe2O4)-based smart magnetic nanoparticles were fabricated and coated with methionine. Physiochemical characterization of the obtained Met-NiFe2O4 nanoparticles revealed the presence of methionine coating over the nanoparticle surface. Drug release study indicated that Tet-Met-NiFe2O4 nanoparticles possess pH-responsive controlled drug release behavior for tetracycline (Tet). The drug loading content for Tet was found to be 0.27 mg/L of nanoparticles. In vitro cytotoxicity test showed that the Met-NiFe2O4 nanoparticles is biocompatible. Moreover, this magnetic nanostructured material shown strong anticancer property as these nanomaterials significantly reduced the viability of A375 cells when compared to free Tet solution. In addition, Tet-Met-NiFe2O4 nanoparticles also showed strong antibacterial activity against different bacterial pathogens. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of Nanomaterials (2079-4991) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.3390/nano12132286
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      – Code: eng
        Text: English
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        PageCount: 15
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    Subjects:
      – SubjectFull: Controlled release drugs
        Type: general
      – SubjectFull: Magnetic nanoparticles
        Type: general
      – SubjectFull: Nanostructured materials
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      – TitleFull: Synthesis and Characterization of Tetracycline Loaded Methionine-Coated NiFe 2 O 4 Nanoparticles for Anticancer and Antibacterial Applications.
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              Text: Jul2022
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