Bibliographic Details
| Title: |
Efficient total synthesis of three alpinoids via the Au(I)-catalyzed Meyer-Schuster rearrangement. |
| Authors: |
Keyes, Jasmine K.1 (AUTHOR), Butzke, Mauri B.1 (AUTHOR), Miller, Kenneth A.1 (AUTHOR) miller_k@fortlewis.edu |
| Source: |
Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry. Aug2022, Vol. 104, pN.PAG-N.PAG. 1p. |
| Subjects: |
Natural products, Antineoplastic agents |
| Abstract: |
[Display omitted] The total syntheses of three structurally related natural products, deoxyalpinoid B, deoxyalpinoid A, and alpinoid F, are reported, and each features a Au(I)-catalyzed Meyer-Schuster rearrangement as the key step. The synthesis of alpinoid F is reported for the first time. The syntheses of these natural products, all of which exhibit potent anticancer activity, are readily amenable to the preparation of structural analogs. [ABSTRACT FROM AUTHOR] |
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| Database: |
Engineering Source |
