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Efficient production of cordycepin by engineered Yarrowia lipolytica from agro-industrial residues.

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Title: Efficient production of cordycepin by engineered Yarrowia lipolytica from agro-industrial residues.
Authors: Duan, Xi-Yu1 (AUTHOR), Liu, Hu-Hu1 (AUTHOR), Song, Li-Ping1 (AUTHOR), Wang, Chong1 (AUTHOR), Yang, Hui1 (AUTHOR), Lu, Xiang-Yang1 (AUTHOR), Ji, Xiao-Jun2 (AUTHOR), Tian, Yun1 (AUTHOR) tianyun@hunau.edu.cn
Source: Bioresource Technology. Jun2023, Vol. 377, pN.PAG-N.PAG. 1p.
Subjects: Pentose phosphate pathway, Diammonium phosphate, Glycolysis, Microbial cells, Industrial costs
Abstract: [Display omitted] • Co-overexpression of GLK1 and PGM1 significantly promoted cordycepin accumulation. • Molasses, DHP, and waste yeast as alternate enhanced cordycepin production. • High C/N molar ratio and weak acidic were more conducive to producing cordycepin. • The cordycepin productivity in the optimized medium was increased by 28.81%. • Using agro-industrial residues can reduce the cost of cordycepin production. Cordycepin, a nucleoside compound with a variety of biological activities, has been extensively applied in the nutraceutical and pharmaceutical industries. The advancement of microbial cell factories using agro-industrial residues provides a sustainable pathway for cordycepin biosynthesis. Herein, the cordycepin production was enhanced by the modification of glycolysis and pentose phosphate pathway in engineered Yarrowia lipolytica. Then, cordycepin production based on economical and renewable substrates (sugarcane molasses, waste spent yeast, and diammonium hydrogen phosphate) was analyzed. Furthermore, the effects of C/N molar ratio and initial pH on cordycepin production were evaluated. Results indicated that the maximum cordycepin productivity of 656.27 mg/L/d (72 h) and cordycepin titer was 2286.04 mg/L (120 h) by engineered Y. lipolytica in the optimized medium, respectively. The cordycepin productivity in the optimized medium was increased by 28.81% compared with the original medium. This research establishes a promising way for efficient cordycepin production from agro-industrial residues. [ABSTRACT FROM AUTHOR]
Copyright of Bioresource Technology is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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DbLabel: Engineering Source
An: 162937621
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  Label: Title
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  Data: Efficient production of cordycepin by engineered Yarrowia lipolytica from agro-industrial residues.
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  Data: <searchLink fieldCode="AR" term="%22Duan%2C+Xi-Yu%22">Duan, Xi-Yu</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Liu%2C+Hu-Hu%22">Liu, Hu-Hu</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Song%2C+Li-Ping%22">Song, Li-Ping</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wang%2C+Chong%22">Wang, Chong</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yang%2C+Hui%22">Yang, Hui</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lu%2C+Xiang-Yang%22">Lu, Xiang-Yang</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ji%2C+Xiao-Jun%22">Ji, Xiao-Jun</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tian%2C+Yun%22">Tian, Yun</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> tianyun@hunau.edu.cn</i>
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  Data: <searchLink fieldCode="JN" term="%22Bioresource+Technology%22">Bioresource Technology</searchLink>. Jun2023, Vol. 377, pN.PAG-N.PAG. 1p.
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  Data: <searchLink fieldCode="DE" term="%22Pentose+phosphate+pathway%22">Pentose phosphate pathway</searchLink><br /><searchLink fieldCode="DE" term="%22Diammonium+phosphate%22">Diammonium phosphate</searchLink><br /><searchLink fieldCode="DE" term="%22Glycolysis%22">Glycolysis</searchLink><br /><searchLink fieldCode="DE" term="%22Microbial+cells%22">Microbial cells</searchLink><br /><searchLink fieldCode="DE" term="%22Industrial+costs%22">Industrial costs</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: [Display omitted] • Co-overexpression of GLK1 and PGM1 significantly promoted cordycepin accumulation. • Molasses, DHP, and waste yeast as alternate enhanced cordycepin production. • High C/N molar ratio and weak acidic were more conducive to producing cordycepin. • The cordycepin productivity in the optimized medium was increased by 28.81%. • Using agro-industrial residues can reduce the cost of cordycepin production. Cordycepin, a nucleoside compound with a variety of biological activities, has been extensively applied in the nutraceutical and pharmaceutical industries. The advancement of microbial cell factories using agro-industrial residues provides a sustainable pathway for cordycepin biosynthesis. Herein, the cordycepin production was enhanced by the modification of glycolysis and pentose phosphate pathway in engineered Yarrowia lipolytica. Then, cordycepin production based on economical and renewable substrates (sugarcane molasses, waste spent yeast, and diammonium hydrogen phosphate) was analyzed. Furthermore, the effects of C/N molar ratio and initial pH on cordycepin production were evaluated. Results indicated that the maximum cordycepin productivity of 656.27 mg/L/d (72 h) and cordycepin titer was 2286.04 mg/L (120 h) by engineered Y. lipolytica in the optimized medium, respectively. The cordycepin productivity in the optimized medium was increased by 28.81% compared with the original medium. This research establishes a promising way for efficient cordycepin production from agro-industrial residues. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Bioresource Technology is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1016/j.biortech.2023.128964
    Languages:
      – Code: eng
        Text: English
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        PageCount: 1
        StartPage: N.PAG
    Subjects:
      – SubjectFull: Pentose phosphate pathway
        Type: general
      – SubjectFull: Diammonium phosphate
        Type: general
      – SubjectFull: Glycolysis
        Type: general
      – SubjectFull: Microbial cells
        Type: general
      – SubjectFull: Industrial costs
        Type: general
    Titles:
      – TitleFull: Efficient production of cordycepin by engineered Yarrowia lipolytica from agro-industrial residues.
        Type: main
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            NameFull: Duan, Xi-Yu
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            NameFull: Liu, Hu-Hu
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            NameFull: Song, Li-Ping
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            NameFull: Wang, Chong
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            NameFull: Yang, Hui
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            NameFull: Lu, Xiang-Yang
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            NameFull: Ji, Xiao-Jun
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            NameFull: Tian, Yun
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            – D: 01
              M: 06
              Text: Jun2023
              Type: published
              Y: 2023
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              Value: 09608524
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            – Type: volume
              Value: 377
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            – TitleFull: Bioresource Technology
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