Enhanced 129Xe T1 relaxation in whole blood and in the presence of SPIONs at low magnetic field strengths.
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| Title: | Enhanced 129Xe T |
|---|---|
| Authors: | Bryden, Nicholas1,2 (AUTHOR), Atalla, Sebastian W.1,2 (AUTHOR), Kelley, Michele1,2 (AUTHOR), Holmes, Leah R.1,2 (AUTHOR), Branca, Rosa T.1,2 (AUTHOR) rtbranca@unc.edu |
| Source: | Magnetic Resonance in Medicine. Jul2023, Vol. 90 Issue 1, p21-33. 13p. |
| Subjects: | Magnetic flux density, Iron oxide nanoparticles, Spectral imaging, Xenon |
| Abstract: | Purpose: To compare the effect of superparamagnetic iron oxide nanoparticles (SPIONs) on the T1 of 129Xe and 1H and to measure the relaxation of 129Xe in blood at low and high magnetic field strengths. Methods: 129Xe and 1H T1 relaxometry was performed at low‐ and high‐field strengths in samples containing different SPION concentrations, while imaging was used to compare the contrast obtainable in these two field regimes. In vivo experiments at variable field strengths were performed to determine the depolarization of 129Xe in blood and the feasibility of in vivo dissolved‐phase spectroscopy and imaging at low field. Results: The SPION relaxivity was substantially greater at low field for 1H, increasing from 0.92 ± 0.06 mM s−1 at 11.7T to 31.5 ± 1.8 mM s−1 at 0.6 mT, and for 129Xe, which increased from 0.13 ± 0.03 mM s−1 at 11.7T to 7.32 ± 0.71 mM s−1 at 2.1 mT. The additional MR signal loss increased from 0.7% at 9.4T to 20.6 ± 4.2% at 0.6 mT for 1H and from −0.7 ± 3.4% at 9.4T to 12.7 ± 3.5% at 2.1 mT for 129Xe. Blood was found to depolarize 129Xe below 3T in a manner inversely proportional to the field strength. In vitro studies at 2.1 mT suggest 129Xe relaxation times below 5 s in blood dilutions as low as 0.4% volume. Conclusion: SPIONs longitudinal relaxivity increases at low field both for 1H and 129Xe. The depolarization of xenon in blood, which is found to increase below 3T, effectively prevents in vivo dissolved‐phase spectroscopy and imaging at low‐field strengths. [ABSTRACT FROM AUTHOR] |
| Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
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| Header | DbId: egs DbLabel: Engineering Source An: 163412726 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Enhanced <superscript>129</superscript>Xe T<subscript>1</subscript> relaxation in whole blood and in the presence of SPIONs at low magnetic field strengths. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Bryden%2C+Nicholas%22">Bryden, Nicholas</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Atalla%2C+Sebastian+W%2E%22">Atalla, Sebastian W.</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kelley%2C+Michele%22">Kelley, Michele</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Holmes%2C+Leah+R%2E%22">Holmes, Leah R.</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Branca%2C+Rosa+T%2E%22">Branca, Rosa T.</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> rtbranca@unc.edu</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Magnetic+Resonance+in+Medicine%22">Magnetic Resonance in Medicine</searchLink>. Jul2023, Vol. 90 Issue 1, p21-33. 13p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Magnetic+flux+density%22">Magnetic flux density</searchLink><br /><searchLink fieldCode="DE" term="%22Iron+oxide+nanoparticles%22">Iron oxide nanoparticles</searchLink><br /><searchLink fieldCode="DE" term="%22Spectral+imaging%22">Spectral imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Xenon%22">Xenon</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Purpose: To compare the effect of superparamagnetic iron oxide nanoparticles (SPIONs) on the T1 of 129Xe and 1H and to measure the relaxation of 129Xe in blood at low and high magnetic field strengths. Methods: 129Xe and 1H T1 relaxometry was performed at low‐ and high‐field strengths in samples containing different SPION concentrations, while imaging was used to compare the contrast obtainable in these two field regimes. In vivo experiments at variable field strengths were performed to determine the depolarization of 129Xe in blood and the feasibility of in vivo dissolved‐phase spectroscopy and imaging at low field. Results: The SPION relaxivity was substantially greater at low field for 1H, increasing from 0.92 ± 0.06 mM s−1 at 11.7T to 31.5 ± 1.8 mM s−1 at 0.6 mT, and for 129Xe, which increased from 0.13 ± 0.03 mM s−1 at 11.7T to 7.32 ± 0.71 mM s−1 at 2.1 mT. The additional MR signal loss increased from 0.7% at 9.4T to 20.6 ± 4.2% at 0.6 mT for 1H and from −0.7 ± 3.4% at 9.4T to 12.7 ± 3.5% at 2.1 mT for 129Xe. Blood was found to depolarize 129Xe below 3T in a manner inversely proportional to the field strength. In vitro studies at 2.1 mT suggest 129Xe relaxation times below 5 s in blood dilutions as low as 0.4% volume. Conclusion: SPIONs longitudinal relaxivity increases at low field both for 1H and 129Xe. The depolarization of xenon in blood, which is found to increase below 3T, effectively prevents in vivo dissolved‐phase spectroscopy and imaging at low‐field strengths. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1002/mrm.29619 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 13 StartPage: 21 Subjects: – SubjectFull: Magnetic flux density Type: general – SubjectFull: Iron oxide nanoparticles Type: general – SubjectFull: Spectral imaging Type: general – SubjectFull: Xenon Type: general Titles: – TitleFull: Enhanced 129Xe T1 relaxation in whole blood and in the presence of SPIONs at low magnetic field strengths. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Bryden, Nicholas – PersonEntity: Name: NameFull: Atalla, Sebastian W. – PersonEntity: Name: NameFull: Kelley, Michele – PersonEntity: Name: NameFull: Holmes, Leah R. – PersonEntity: Name: NameFull: Branca, Rosa T. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 07 Text: Jul2023 Type: published Y: 2023 Identifiers: – Type: issn-print Value: 07403194 Numbering: – Type: volume Value: 90 – Type: issue Value: 1 Titles: – TitleFull: Magnetic Resonance in Medicine Type: main |
| ResultId | 1 |
