Bibliographic Details
| Title: |
Targeted evolution of adeno-associated virus capsids for systemic transgene delivery to microglia and tissue-resident macrophages. |
| Authors: |
Young, Adam1,2, Neumann, Bjoern1,2, Segel, Michael1, Zi-Yu Chen, Civia1,2, Tourlomousis, Panagiotis3, Franklin, Robin J. M.1,2 rfranklin@altoslabs.com |
| Source: |
Proceedings of the National Academy of Sciences of the United States of America. 8/29/2023, Vol. 120 Issue 35, p1-3. 6p. |
| Subjects: |
Adeno-associated virus, Microglia, Macrophages, Capsids, Transgene expression |
| Abstract: |
Tissue macrophages, including microglia, are notoriously resistant to genetic manipulation. Here, we report the creation of Adeno-associated viruses (AAV) variants that efficiently and widely transduce microglia and tissue macrophages in vivo following intravenous delivery, with transgene expression of up to 80%. We use this technology to demonstrate manipulation of microglia gene expression and microglial ablation, thereby providing invaluable research tools for the study of these important cells. [ABSTRACT FROM AUTHOR] |
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| Database: |
Engineering Source |
