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Dose-response dependencies of OSL dosimeters in conventional linacs and 1.5T MR-linacs: an experimental and Monte Carlo study.

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Title: Dose-response dependencies of OSL dosimeters in conventional linacs and 1.5T MR-linacs: an experimental and Monte Carlo study.
Authors: Episkopakis, Anastasios1,2 (AUTHOR), Margaroni, Vasiliki1 (AUTHOR), Kanellopoulou, Stamatiki3 (AUTHOR), Marinos, Nikolas2 (AUTHOR), Koutsouveli, Efi4 (AUTHOR), Karaiskos, Pantelis1 (AUTHOR), Pappas, Eleftherios P1 (AUTHOR) elepappas@med.uoa.gr
Source: Physics in Medicine & Biology. 11/21/2023, Vol. 68 Issue 22, p1-16. 16p.
Subjects: Optically stimulated luminescence, Dosimeters, Medical dosimetry, Magnetic resonance imaging, Magnetic fields, Linear accelerators, Photon beams
Abstract: Objective. This work focuses on the optically stimulated luminescence dosimetry (OSLD) dose–response characterization, with emphasis on 1.5T MR-Linacs. Approach. Throughout this study, the nanoDots OSLDs (Landauer, USA) were considered. In groups of three, the mean OSLD response was measured in a conventional linac and an MR-Linac under various irradiation conditions to investigate (i) dose–response linearity with and without the 1.5T magnetic field, (ii) signal fading rate and its dependencies, (iii) beam quality, detector orientation and dose rate dependencies in a conventional linac, (iii) potential MR imaging related effects on OSLD response and (iv) detector orientation dependence in an MR-Linac. Monte Carlo calculations were performed to further quantify angular dependence after rotating the detector around its central axis parallel to the magnetic field, and determine the magnetic field correction factors, k B , Q , for all cardinal detector orientations. Main results. OSLD dose–response supralinearity in an MR-Linac setting was found to agree within uncertainties with the corresponding one in a conventional linac, for the axial detector orientation investigated. Signal fading rate does not depend on irradiation conditions for the range of 3–30 d considered. OSLD angular (orientation) dependence is more pronounced under the presence of a magnetic field. OSLDs irradiated with and without real-time T2w MR imaging enabled during irradiation yielded the same response within uncertainties. k B , Q values were determined for all three cardinal orientations. Corrections needed reached up to 6.4%. However, if OSLDs are calibrated in the axial orientation and then irradiated in an MR-Linac placed again in the axial orientation (perpendicular to the magnetic field), then simulations suggest that k B , Q can be considered unity within uncertainties, irrespective of the incident beam angle. Significance. This work contributes towards OSLD dose–response characterization and relevant correction factors availability. OSLDs are suitable for QA checks in MR-based beam gating applications and in vivo dosimetry in MR-Linacs. [ABSTRACT FROM AUTHOR]
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Database: Engineering Source
Description
Abstract:Objective. This work focuses on the optically stimulated luminescence dosimetry (OSLD) dose–response characterization, with emphasis on 1.5T MR-Linacs. Approach. Throughout this study, the nanoDots OSLDs (Landauer, USA) were considered. In groups of three, the mean OSLD response was measured in a conventional linac and an MR-Linac under various irradiation conditions to investigate (i) dose–response linearity with and without the 1.5T magnetic field, (ii) signal fading rate and its dependencies, (iii) beam quality, detector orientation and dose rate dependencies in a conventional linac, (iii) potential MR imaging related effects on OSLD response and (iv) detector orientation dependence in an MR-Linac. Monte Carlo calculations were performed to further quantify angular dependence after rotating the detector around its central axis parallel to the magnetic field, and determine the magnetic field correction factors, k B , Q , for all cardinal detector orientations. Main results. OSLD dose–response supralinearity in an MR-Linac setting was found to agree within uncertainties with the corresponding one in a conventional linac, for the axial detector orientation investigated. Signal fading rate does not depend on irradiation conditions for the range of 3–30 d considered. OSLD angular (orientation) dependence is more pronounced under the presence of a magnetic field. OSLDs irradiated with and without real-time T2w MR imaging enabled during irradiation yielded the same response within uncertainties. k B , Q values were determined for all three cardinal orientations. Corrections needed reached up to 6.4%. However, if OSLDs are calibrated in the axial orientation and then irradiated in an MR-Linac placed again in the axial orientation (perpendicular to the magnetic field), then simulations suggest that k B , Q can be considered unity within uncertainties, irrespective of the incident beam angle. Significance. This work contributes towards OSLD dose–response characterization and relevant correction factors availability. OSLDs are suitable for QA checks in MR-based beam gating applications and in vivo dosimetry in MR-Linacs. [ABSTRACT FROM AUTHOR]
ISSN:00319155
DOI:10.1088/1361-6560/ad051e