Circadian Modulation of Ventricular Tachycardia Cycle Length Variability in ICD Patients with Dilated Cardiomyopathy.

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Bibliographic Details
Title:	Circadian Modulation of Ventricular Tachycardia Cycle Length Variability in ICD Patients with Dilated Cardiomyopathy.
Authors:	Manolis, Athanasios G.¹, Katsivas, Apostolos¹, Lazaris, Eustathios¹, Koutsogeogis, Dimitrios¹, Louvros, Nikolaos¹
Source:	Pacing & Clinical Electrophysiology. Jan1997, Vol. 20 Issue 1, p203-207. 5p.
Subjects:	Tachycardia, Cardiomyopathies, Cardiac patients, Circadian rhythms, Biological rhythms, Heart diseases
Abstract:	VT is usually characterized hy stability of the HR intervals after a few cycles from the onset. The aim of this study was to evaluate the VT cycle length (VTCL) variability in patients with dilated cardiomyopathy (DCM), in whom a third-generation ICD was previously implanted. Eighty-three episodes of VT were analyzed in 70 patients (8 male, 2 female, 65 ± 6 years) with DCM, and NYHA Class II (7 patients) or III (3 patients). As an index of VTCL variability, the coefficient of variance of the last 15 consecutive RR intervals (CVRR) of the detected and stored VT by the device was considered. The mean value of the HR intervals and the mean value of CVHR of the VT episodes recorded during day versus night time were compared. Fifty-five VT episodes were recorded during the day and 28 episodes during the night time. The mean HH intervals of VT episodes during day time was 335 ± 29 ms and during the night time was 350 ±22 ms (P = NS). The mean CVHH of VT episodes during day time and night time were 2.83 ± 0.52 and 3.36 ± 0.48, respectively (P = 0.017). In conclusion, a circadian modulation of VTCL variability exists in patients with DCM. The VTCL variability is less during day time compared to night time. A possible explanation is a circadian alteration of sympathovagal balance modifying the electrophysiological properties of the arrhythmogenic substrate. [ABSTRACT FROM AUTHOR]
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Database:	Engineering Source

Description
Abstract:	VT is usually characterized hy stability of the HR intervals after a few cycles from the onset. The aim of this study was to evaluate the VT cycle length (VTCL) variability in patients with dilated cardiomyopathy (DCM), in whom a third-generation ICD was previously implanted. Eighty-three episodes of VT were analyzed in 70 patients (8 male, 2 female, 65 ± 6 years) with DCM, and NYHA Class II (7 patients) or III (3 patients). As an index of VTCL variability, the coefficient of variance of the last 15 consecutive RR intervals (CVRR) of the detected and stored VT by the device was considered. The mean value of the HR intervals and the mean value of CVHR of the VT episodes recorded during day versus night time were compared. Fifty-five VT episodes were recorded during the day and 28 episodes during the night time. The mean HH intervals of VT episodes during day time was 335 ± 29 ms and during the night time was 350 ±22 ms (P = NS). The mean CVHH of VT episodes during day time and night time were 2.83 ± 0.52 and 3.36 ± 0.48, respectively (P = 0.017). In conclusion, a circadian modulation of VTCL variability exists in patients with DCM. The VTCL variability is less during day time compared to night time. A possible explanation is a circadian alteration of sympathovagal balance modifying the electrophysiological properties of the arrhythmogenic substrate. [ABSTRACT FROM AUTHOR]
ISSN:	01478389
DOI:	10.1111/j.1540-8159.1997.tb04843.x