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The Polysaccharide from Dendrobium officinale Can Improve Mice with Sjögren's Syndrome by Regulating BAFF and Fas Expressions.

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Title: The Polysaccharide from Dendrobium officinale Can Improve Mice with Sjögren's Syndrome by Regulating BAFF and Fas Expressions.
Authors: Zhu, Pengpeng1 (AUTHOR), Ou, Guoteng2 (AUTHOR), Zhou, Ting1 (AUTHOR), Zhu, Wenwen1 (AUTHOR), Sun, Wei2 (AUTHOR), Wei, Xueping2 (AUTHOR), Huang, Rongrong2 (AUTHOR), Jing, Junsong2 (AUTHOR), Zhang, Sheng3 (AUTHOR), Hu, Jingjin2 (AUTHOR), Li, Yuanyuan1 (AUTHOR), Liu, Hua2 (AUTHOR), Shen, Tangbiao2 (AUTHOR), Zhao, Zhengrong1 (AUTHOR), Wu, Yueguo1,4 (AUTHOR)
Source: Journal of Food Biochemistry. 12/28/2023, p1-14. 14p.
Subjects: Sjogren's syndrome, Gene expression, Polysaccharides, Dendrobium, BCL genes, Submandibular gland
Abstract: Exploring herbs and their compounds for potential drugs is a significant research focus due to the incurable nature of Sjögren's syndrome (SS), a prevalent chronic inflammatory autoimmune disease. Dendrobium officinale polysaccharide (DOP) has demonstrated diverse biological effects, particularly in immunomodulation. Nonetheless, limited research has been conducted on DOP concerning the treatment of SS. This research aims to examine the impacts of DOP on experimental SS (ESS) mice and its possible mechanisms. An ESS animal model was established using the immune induction method. Besides the control group, ESS mice were randomly assigned to the model (distilled water), the HCQ (60 mg/kg), the DOP (43 mg/kg), the DOP (130 mg/kg), and the DOP (390 mg/kg) groups. Drugs were treated for three weeks. The findings indicated that DOP enhanced saliva production of ESS mice and diminished lymphocyte infiltration and foci in the submandibular gland (SMG). DOP also significantly downregulated the mRNA content of proinflammatory factors (TNF-α, IL-1β, and IL-17) and the expression of genes and proteins of apoptotic factors (Bax and Caspase-3). Furthermore, DOP downregulated the BAFF and BAFF receptor (BAFFR) as well as Fas and Fas ligand (Fas-L) expressions in the SMG. Our study demonstrates that DOP may reduce inflammation and apoptosis by inhibiting BAFF/BAFFR and Fas/Fas-L signaling, thus producing therapeutic effects in ESS mice. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Food Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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An: 174635339
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PubTypeId: academicJournal
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  Label: Title
  Group: Ti
  Data: The Polysaccharide from Dendrobium officinale Can Improve Mice with Sjögren's Syndrome by Regulating BAFF and Fas Expressions.
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  Data: <searchLink fieldCode="AR" term="%22Zhu%2C+Pengpeng%22">Zhu, Pengpeng</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ou%2C+Guoteng%22">Ou, Guoteng</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhou%2C+Ting%22">Zhou, Ting</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhu%2C+Wenwen%22">Zhu, Wenwen</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sun%2C+Wei%22">Sun, Wei</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wei%2C+Xueping%22">Wei, Xueping</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Huang%2C+Rongrong%22">Huang, Rongrong</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Jing%2C+Junsong%22">Jing, Junsong</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhang%2C+Sheng%22">Zhang, Sheng</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hu%2C+Jingjin%22">Hu, Jingjin</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Li%2C+Yuanyuan%22">Li, Yuanyuan</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Liu%2C+Hua%22">Liu, Hua</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Shen%2C+Tangbiao%22">Shen, Tangbiao</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhao%2C+Zhengrong%22">Zhao, Zhengrong</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wu%2C+Yueguo%22">Wu, Yueguo</searchLink><relatesTo>1,4</relatesTo> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Food+Biochemistry%22">Journal of Food Biochemistry</searchLink>. 12/28/2023, p1-14. 14p.
– Name: Subject
  Label: Subjects
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  Data: <searchLink fieldCode="DE" term="%22Sjogren's+syndrome%22">Sjogren's syndrome</searchLink><br /><searchLink fieldCode="DE" term="%22Gene+expression%22">Gene expression</searchLink><br /><searchLink fieldCode="DE" term="%22Polysaccharides%22">Polysaccharides</searchLink><br /><searchLink fieldCode="DE" term="%22Dendrobium%22">Dendrobium</searchLink><br /><searchLink fieldCode="DE" term="%22BCL+genes%22">BCL genes</searchLink><br /><searchLink fieldCode="DE" term="%22Submandibular+gland%22">Submandibular gland</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Exploring herbs and their compounds for potential drugs is a significant research focus due to the incurable nature of Sjögren's syndrome (SS), a prevalent chronic inflammatory autoimmune disease. Dendrobium officinale polysaccharide (DOP) has demonstrated diverse biological effects, particularly in immunomodulation. Nonetheless, limited research has been conducted on DOP concerning the treatment of SS. This research aims to examine the impacts of DOP on experimental SS (ESS) mice and its possible mechanisms. An ESS animal model was established using the immune induction method. Besides the control group, ESS mice were randomly assigned to the model (distilled water), the HCQ (60 mg/kg), the DOP (43 mg/kg), the DOP (130 mg/kg), and the DOP (390 mg/kg) groups. Drugs were treated for three weeks. The findings indicated that DOP enhanced saliva production of ESS mice and diminished lymphocyte infiltration and foci in the submandibular gland (SMG). DOP also significantly downregulated the mRNA content of proinflammatory factors (TNF-α, IL-1β, and IL-17) and the expression of genes and proteins of apoptotic factors (Bax and Caspase-3). Furthermore, DOP downregulated the BAFF and BAFF receptor (BAFFR) as well as Fas and Fas ligand (Fas-L) expressions in the SMG. Our study demonstrates that DOP may reduce inflammation and apoptosis by inhibiting BAFF/BAFFR and Fas/Fas-L signaling, thus producing therapeutic effects in ESS mice. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of Food Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1155/2023/4733651
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 14
        StartPage: 1
    Subjects:
      – SubjectFull: Sjogren's syndrome
        Type: general
      – SubjectFull: Gene expression
        Type: general
      – SubjectFull: Polysaccharides
        Type: general
      – SubjectFull: Dendrobium
        Type: general
      – SubjectFull: BCL genes
        Type: general
      – SubjectFull: Submandibular gland
        Type: general
    Titles:
      – TitleFull: The Polysaccharide from Dendrobium officinale Can Improve Mice with Sjögren's Syndrome by Regulating BAFF and Fas Expressions.
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            – D: 28
              M: 12
              Text: 12/28/2023
              Type: published
              Y: 2023
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