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Recent developments using malononitrile in ultrasound-assisted multicomponent synthesis of heterocycles.

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Title: Recent developments using malononitrile in ultrasound-assisted multicomponent synthesis of heterocycles.
Authors: Javahershenas, Ramin1 (AUTHOR) jshbco@gmail.com, Nikzat, Sahand2 (AUTHOR) sahand.nikzat@mail.utoronto.ca
Source: Ultrasonics Sonochemistry. Jan2024, Vol. 102, pN.PAG-N.PAG. 1p.
Subjects: Malononitrile, Heterocyclic compounds, Sonochemistry
Abstract: [Display omitted] • Malononitrile. • Ultrasound. • Sonochemistry. • Heterocycles. • Multicomponent reactions. • Synthesis. Ultrasonic irradiation serves as a vigorous and environmentally sustainable approach for augmenting multicomponent reactions (MCRs), offering benefits such as thermal enhancement, agitation, and activation, among others. Malononitrile emerges as a versatile reagent in this context, participating in a myriad of MCRs to produce structurally diverse heterocyclic frameworks. This review encapsulates the critical role of malononitrile in the sonochemical multicomponent synthesis of these heterocyclic structures. The paper further delves into the biochemical and pharmacological implications of these heterocycles, elucidating their reaction mechanisms as well as delineating the method's scope and limitations. We furnish an overview of the merits and challenges inherent to this synthetic approach and offer insights for potential avenues in future research. [ABSTRACT FROM AUTHOR]
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Database: Engineering Source
Description
Abstract:[Display omitted] • Malononitrile. • Ultrasound. • Sonochemistry. • Heterocycles. • Multicomponent reactions. • Synthesis. Ultrasonic irradiation serves as a vigorous and environmentally sustainable approach for augmenting multicomponent reactions (MCRs), offering benefits such as thermal enhancement, agitation, and activation, among others. Malononitrile emerges as a versatile reagent in this context, participating in a myriad of MCRs to produce structurally diverse heterocyclic frameworks. This review encapsulates the critical role of malononitrile in the sonochemical multicomponent synthesis of these heterocyclic structures. The paper further delves into the biochemical and pharmacological implications of these heterocycles, elucidating their reaction mechanisms as well as delineating the method's scope and limitations. We furnish an overview of the merits and challenges inherent to this synthetic approach and offer insights for potential avenues in future research. [ABSTRACT FROM AUTHOR]
ISSN:13504177
DOI:10.1016/j.ultsonch.2023.106741