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Facile synthesis of aryl and benzyl substituted 2-methylquinazolin-4(3H)-one ring by microfluidic flow reaction chemistry.

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Title: Facile synthesis of aryl and benzyl substituted 2-methylquinazolin-4(3H)-one ring by microfluidic flow reaction chemistry.
Authors: Wi, Dongwook1 (AUTHOR), Campagna, Jesus1 (AUTHOR), Cohn, Whitaker1 (AUTHOR), Lee, Jessica1 (AUTHOR), Cole, Terran1 (AUTHOR), Jagodzinska, Barbara1 (AUTHOR), John, Varghese1 (AUTHOR) VJohn@mednet.ucla.edu
Source: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry. Mar2024, Vol. 138, pN.PAG-N.PAG. 1p.
Subjects: Flow chemistry, Chemical reactions, Continuous flow reactors, Electrical load, Ring formation (Chemistry), Quinazolinones
Abstract: [Display omitted] This study describes the development of a new and rapid synthesis procedure for performing the aryl and benzyl substituted 2-methylquinazolin-4(3H)-one ring cyclization reaction. We utilized a continuous-flow microfluidic reactor for the production of quinazolinone derivatives of a humanin peptide mimetic screening hit in a facile manner, offering a cleaner reaction profile, high yield, and quick scalability. Our results show the power of flow chemistry to this reaction and can be of general utility for synthesizing quinazolinone-containing intermediates and final products of industrial importance in a continuous and safe manner. [ABSTRACT FROM AUTHOR]
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Database: Engineering Source
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Abstract:[Display omitted] This study describes the development of a new and rapid synthesis procedure for performing the aryl and benzyl substituted 2-methylquinazolin-4(3H)-one ring cyclization reaction. We utilized a continuous-flow microfluidic reactor for the production of quinazolinone derivatives of a humanin peptide mimetic screening hit in a facile manner, offering a cleaner reaction profile, high yield, and quick scalability. Our results show the power of flow chemistry to this reaction and can be of general utility for synthesizing quinazolinone-containing intermediates and final products of industrial importance in a continuous and safe manner. [ABSTRACT FROM AUTHOR]
ISSN:00404039
DOI:10.1016/j.tetlet.2024.154961