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Facile synthesis of aryl and benzyl substituted 2-methylquinazolin-4(3H)-one ring by microfluidic flow reaction chemistry.

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Title: Facile synthesis of aryl and benzyl substituted 2-methylquinazolin-4(3H)-one ring by microfluidic flow reaction chemistry.
Authors: Wi, Dongwook1 (AUTHOR), Campagna, Jesus1 (AUTHOR), Cohn, Whitaker1 (AUTHOR), Lee, Jessica1 (AUTHOR), Cole, Terran1 (AUTHOR), Jagodzinska, Barbara1 (AUTHOR), John, Varghese1 (AUTHOR) VJohn@mednet.ucla.edu
Source: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry. Mar2024, Vol. 138, pN.PAG-N.PAG. 1p.
Subjects: Flow chemistry, Chemical reactions, Continuous flow reactors, Electrical load, Ring formation (Chemistry), Quinazolinones
Abstract: [Display omitted] This study describes the development of a new and rapid synthesis procedure for performing the aryl and benzyl substituted 2-methylquinazolin-4(3H)-one ring cyclization reaction. We utilized a continuous-flow microfluidic reactor for the production of quinazolinone derivatives of a humanin peptide mimetic screening hit in a facile manner, offering a cleaner reaction profile, high yield, and quick scalability. Our results show the power of flow chemistry to this reaction and can be of general utility for synthesizing quinazolinone-containing intermediates and final products of industrial importance in a continuous and safe manner. [ABSTRACT FROM AUTHOR]
Copyright of Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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Header DbId: egs
DbLabel: Engineering Source
An: 175983282
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Data: Facile synthesis of aryl and benzyl substituted 2-methylquinazolin-4(3H)-one ring by microfluidic flow reaction chemistry.
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  Data: <searchLink fieldCode="JN" term="%22Tetrahedron+Letters%3A+International+Organ+for+the+Rapid+Publication+of+Preliminary+Communications+in+Organic+Chemistry%22">Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry</searchLink>. Mar2024, Vol. 138, pN.PAG-N.PAG. 1p.
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  Data: <searchLink fieldCode="DE" term="%22Flow+chemistry%22">Flow chemistry</searchLink><br /><searchLink fieldCode="DE" term="%22Chemical+reactions%22">Chemical reactions</searchLink><br /><searchLink fieldCode="DE" term="%22Continuous+flow+reactors%22">Continuous flow reactors</searchLink><br /><searchLink fieldCode="DE" term="%22Electrical+load%22">Electrical load</searchLink><br /><searchLink fieldCode="DE" term="%22Ring+formation+%28Chemistry%29%22">Ring formation (Chemistry)</searchLink><br /><searchLink fieldCode="DE" term="%22Quinazolinones%22">Quinazolinones</searchLink>
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  Data: [Display omitted] This study describes the development of a new and rapid synthesis procedure for performing the aryl and benzyl substituted 2-methylquinazolin-4(3H)-one ring cyclization reaction. We utilized a continuous-flow microfluidic reactor for the production of quinazolinone derivatives of a humanin peptide mimetic screening hit in a facile manner, offering a cleaner reaction profile, high yield, and quick scalability. Our results show the power of flow chemistry to this reaction and can be of general utility for synthesizing quinazolinone-containing intermediates and final products of industrial importance in a continuous and safe manner. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1016/j.tetlet.2024.154961
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      – Code: eng
        Text: English
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        PageCount: 1
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      – SubjectFull: Flow chemistry
        Type: general
      – SubjectFull: Chemical reactions
        Type: general
      – SubjectFull: Continuous flow reactors
        Type: general
      – SubjectFull: Electrical load
        Type: general
      – SubjectFull: Ring formation (Chemistry)
        Type: general
      – SubjectFull: Quinazolinones
        Type: general
    Titles:
      – TitleFull: Facile synthesis of aryl and benzyl substituted 2-methylquinazolin-4(3H)-one ring by microfluidic flow reaction chemistry.
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            NameFull: Wi, Dongwook
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            NameFull: Campagna, Jesus
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            NameFull: Cole, Terran
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            NameFull: Jagodzinska, Barbara
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              Text: Mar2024
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              Y: 2024
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              Value: 138
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