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1,2-Diboranes with strong donor substitutes: Synthesis, ovicidal and larvicidal effect on important vector species.

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Title: 1,2-Diboranes with strong donor substitutes: Synthesis, ovicidal and larvicidal effect on important vector species.
Authors: Bursalı, Fatma1 (AUTHOR), Şahin, Yüksel1 (AUTHOR) ysahin@adu.edu.tr, Aygün, Muhittin2 (AUTHOR), Sevincek, Resul2 (AUTHOR), Bıyık, H. Halil1 (AUTHOR), Özgener, Hüseyin3 (AUTHOR), Gürbüz, Burçin1 (AUTHOR)
Source: Inorganic Chemistry Communications. Apr2024, Vol. 162, pN.PAG-N.PAG. 1p.
Subjects: Insecticides, Aedes aegypti, Nuclear magnetic resonance spectroscopy, Aedes albopictus, Non-target organisms, Species
Abstract: New 1,2- diborane derivatives were synthesized and characterized. Some compounds have strong ovicidal and larvicidal effects. These results reveal that 1,2-diborane derivatives have ovicidal and larvicidal effects on mosquitoes and therefore are potential candidates for the development of new larvicides. [Display omitted] • New 1,2-diborane derivatives were synthesized and characterized. • Their ovicidal and larvicidal activities against eggs and larvae of Ae aegypti and Aedes albopictus mosquito species were determined. • Derivatives of 1,2-Diborane were found to have ovicidal and larvicidal effects on mosquitoes and thus are potential candidates for the development of novel control agents. Novel control products are needed in the control of important insects like mosquitoes which are developing resistance to insecticides and larvicides currently in the market. Boron compounds have been demonstrated to exhibit antibacterial and anticancer effects. 1,2-diboranes with a long history and importance in boron chemistry have been described. These compounds are synthesized from reactions of 1,2-dichlordiborane derivatives with lidium amides (ArNHLi/Et 2 NLi, etc.). In addition to the three previously synthesized diborane compounds, five novel 1,2-diborane compounds were synthesized in good yield using the same method for the first time. The structures of the novel derivatives were characterized by nuclear magnetic resonance spectroscopy, and the molecular structure of one of them (2a) was also demonstrated using single crystal X-ray diffraction. In this preliminary study, the ovicidal and larvicidal effects of new 1,2-diamino-1,2-diborane derivatives against Aedes aegypti and Aedes albopictus eggs and larvae were investigated for the first time. Of these, 2a and 2e showed the highest ovicidal activity against both species, while 7 , 4 and 2d showed particularly high larvicidal activity. Some 1,2-diborane derivatives were found to be significantly toxic, with LC 50 values ranging from 14,930 to 27,975 μg/mL. Some derivatives (6, 2a, 2c) were less effective against mosquito larvae. 1,2-Diborane derivatives have high ovicidal and larvicidal effects on mosquitoes and are therefore potential candidates for the development of new larvicides. Further studies are needed to evaluate its mode of action and safety. Understanding their mode of action against mosquito development is crucial to optimizing their use and reducing the potential development of resistance. Their potential effects on other mosquito species and non-target organisms need to be investigated. [ABSTRACT FROM AUTHOR]
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Description
Abstract:New 1,2- diborane derivatives were synthesized and characterized. Some compounds have strong ovicidal and larvicidal effects. These results reveal that 1,2-diborane derivatives have ovicidal and larvicidal effects on mosquitoes and therefore are potential candidates for the development of new larvicides. [Display omitted] • New 1,2-diborane derivatives were synthesized and characterized. • Their ovicidal and larvicidal activities against eggs and larvae of Ae aegypti and Aedes albopictus mosquito species were determined. • Derivatives of 1,2-Diborane were found to have ovicidal and larvicidal effects on mosquitoes and thus are potential candidates for the development of novel control agents. Novel control products are needed in the control of important insects like mosquitoes which are developing resistance to insecticides and larvicides currently in the market. Boron compounds have been demonstrated to exhibit antibacterial and anticancer effects. 1,2-diboranes with a long history and importance in boron chemistry have been described. These compounds are synthesized from reactions of 1,2-dichlordiborane derivatives with lidium amides (ArNHLi/Et 2 NLi, etc.). In addition to the three previously synthesized diborane compounds, five novel 1,2-diborane compounds were synthesized in good yield using the same method for the first time. The structures of the novel derivatives were characterized by nuclear magnetic resonance spectroscopy, and the molecular structure of one of them (2a) was also demonstrated using single crystal X-ray diffraction. In this preliminary study, the ovicidal and larvicidal effects of new 1,2-diamino-1,2-diborane derivatives against Aedes aegypti and Aedes albopictus eggs and larvae were investigated for the first time. Of these, 2a and 2e showed the highest ovicidal activity against both species, while 7 , 4 and 2d showed particularly high larvicidal activity. Some 1,2-diborane derivatives were found to be significantly toxic, with LC 50 values ranging from 14,930 to 27,975 μg/mL. Some derivatives (6, 2a, 2c) were less effective against mosquito larvae. 1,2-Diborane derivatives have high ovicidal and larvicidal effects on mosquitoes and are therefore potential candidates for the development of new larvicides. Further studies are needed to evaluate its mode of action and safety. Understanding their mode of action against mosquito development is crucial to optimizing their use and reducing the potential development of resistance. Their potential effects on other mosquito species and non-target organisms need to be investigated. [ABSTRACT FROM AUTHOR]
ISSN:13877003
DOI:10.1016/j.inoche.2024.112268