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Opportunities and challenges of polyphenols and polysaccharides for type 1 diabetes intervention.

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Title: Opportunities and challenges of polyphenols and polysaccharides for type 1 diabetes intervention.
Authors: Li, Binbin1,2 (AUTHOR), Pan, Li-Long3 (AUTHOR), Pan, Xiaohua1,2 (AUTHOR), Dong, Xiaoliang3 (AUTHOR), Ren, Zhengnan1,2 (AUTHOR), Zhang, Hao1,2 (AUTHOR), Chen, Wei1,2 (AUTHOR), de Vos, Paul4 (AUTHOR), Sun, Jia1,2 (AUTHOR) jiasun@jiangnan.edu.cn
Source: Critical Reviews in Food Science & Nutrition. 2024, Vol. 64 Issue 10, p2811-2823. 13p.
Subjects: Type 1 diabetes, Polyphenols, Autoimmune diseases, Plant polyphenols, Burden of care, Gut microbiota, Insulin, Epigallocatechin gallate
Abstract: Type 1 diabetes (T1D) is an autoimmune disorder characterized by the destruction of insulin-producing pancreatic β cell. It contributes to high mortality, frequent diabetic complications, poor quality of life in patients and also puts a significant economic burden on health care systems. Therefore, the development of new therapeutic strategies is urgently needed. Recently, certain dietary compounds with potential applications in food industry, particularly polyphenols and polysaccharides, have gained increasing attention with their prominent anti-diabetic effects on T1D by modulating β cell function, the gut microbiota and/or the immune system. In this review, we critically discuss the recent findings of several dietary polyphenols and polysaccharides with the potential to protect against T1D and the underlying anti-diabetic mechanisms. More importantly, we highlight the current trends, major issues, and future directions of industrial production of polyphenols- and polysaccharides-based functional foods for preventing or delaying T1D. [ABSTRACT FROM AUTHOR]
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Database: Engineering Source
Description
Abstract:Type 1 diabetes (T1D) is an autoimmune disorder characterized by the destruction of insulin-producing pancreatic β cell. It contributes to high mortality, frequent diabetic complications, poor quality of life in patients and also puts a significant economic burden on health care systems. Therefore, the development of new therapeutic strategies is urgently needed. Recently, certain dietary compounds with potential applications in food industry, particularly polyphenols and polysaccharides, have gained increasing attention with their prominent anti-diabetic effects on T1D by modulating β cell function, the gut microbiota and/or the immune system. In this review, we critically discuss the recent findings of several dietary polyphenols and polysaccharides with the potential to protect against T1D and the underlying anti-diabetic mechanisms. More importantly, we highlight the current trends, major issues, and future directions of industrial production of polyphenols- and polysaccharides-based functional foods for preventing or delaying T1D. [ABSTRACT FROM AUTHOR]
ISSN:10408398
DOI:10.1080/10408398.2022.2126962