"Everything Everywhere All at Once": Unraveling perfusion, permeability, and leakage effects in neurooncology with a single-dose, single-acquisition dual-echo DSC.
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| Title: | "Everything Everywhere All at Once": Unraveling perfusion, permeability, and leakage effects in neurooncology with a single-dose, single-acquisition dual-echo DSC. |
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| Authors: | Pons-Escoda, Albert1,2 (AUTHOR) albert.pons@bellvitgehospital.cat |
| Source: | European Radiology. May2024, Vol. 34 Issue 5, p3084-3086. 3p. |
| Subjects: | Permeability, Leakage, Perfusion, Cerebellar tumors, Patient experience |
| Abstract: | The article discusses a novel workflow presented by Sanvito et al in European Radiology that allows for the simultaneous quantification of perfusion, permeability, and leakage effects in neurooncology using a single-dose, single-acquisition dual-echo DSC sequence. Traditionally, these measurements require two separate acquisitions, increasing scanning time and contrast agent dose. The new pipeline introduced in this study eliminates the need for a separate acquisition, significantly reducing scanning time and required contrast agent dose. The authors also propose a quantitative biomarker called "Transverse Relaxivity at Tracer Equilibrium" (TRATE) that correlates with cellularity in enhancing gliomas. Additionally, the study explores differences between different types of gliomas and suggests that a metric called ΔR1,ss could potentially serve as a surrogate for the measurement of BBB rupture. The article provides valuable insights and correlations with biological processes, making it useful for both academic and clinical readers interested in DSC imaging. [Extracted from the article] |
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| Database: | Engineering Source |
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| Abstract: | The article discusses a novel workflow presented by Sanvito et al in European Radiology that allows for the simultaneous quantification of perfusion, permeability, and leakage effects in neurooncology using a single-dose, single-acquisition dual-echo DSC sequence. Traditionally, these measurements require two separate acquisitions, increasing scanning time and contrast agent dose. The new pipeline introduced in this study eliminates the need for a separate acquisition, significantly reducing scanning time and required contrast agent dose. The authors also propose a quantitative biomarker called "Transverse Relaxivity at Tracer Equilibrium" (TRATE) that correlates with cellularity in enhancing gliomas. Additionally, the study explores differences between different types of gliomas and suggests that a metric called ΔR1,ss could potentially serve as a surrogate for the measurement of BBB rupture. The article provides valuable insights and correlations with biological processes, making it useful for both academic and clinical readers interested in DSC imaging. [Extracted from the article] |
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| ISSN: | 09387994 |
| DOI: | 10.1007/s00330-023-10277-z |
