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Hydrothermal synthesis of carbon dots incorporated in magnetite iron oxide nanoparticles for potential targeted brain cancer therapy: In-Vitro study.

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Title: Hydrothermal synthesis of carbon dots incorporated in magnetite iron oxide nanoparticles for potential targeted brain cancer therapy: In-Vitro study.
Authors: Yaqoob, Zahida1,2 (AUTHOR), Batool, Syeda Ammara2 (AUTHOR), Abdul Basit, Muhammad2 (AUTHOR), Konain, Kiran3 (AUTHOR), Malik, Rizwan Ahmed4 (AUTHOR), Rehman, Saeed Ur5 (AUTHOR), Hussain, Syed Wilayat2 (AUTHOR), Alrobei, Hussein1,4 (AUTHOR) H.alrobei@psau.edu.sa, Ur Rehman, Muhammad Atiq1 (AUTHOR)
Source: Materials Chemistry & Physics. Sep2024, Vol. 324, pN.PAG-N.PAG. 1p.
Subjects: Iron oxides, Brain cancer, Magnetite, Hydrothermal synthesis, Cancer treatment, Iron oxide nanoparticles, Cytocompatibility
Abstract: Surface modification of magnetite (Fe 3 O 4) nanoparticles (NPs) using carbon dots (CDs) is a promising approach in biomedical applications due to excellent biocompatibility. Herein, the CDs were incorporated in the Fe 3 O 4 NPs to observe the performance of CDs-Fe 3 O 4 NPs for targeted brain cancer therapy. Scanning electron microscopy (SEM) images revealed the morphology of Fe 3 O 4 NPs is rough and agglomerated. X-ray diffraction (XRD) diffraction pattern exhibits that the CDs are successfully incorporated in Fe 3 O 4 NPs. Furthermore, magnetic properties evaluated using vibrating sample magnetometer (VSM) exhibited significant magnetization (51.362 emu/g) attributed to the greater occupancy of Fe+2 ions in the crystal lattice. XRD pattern confirmed the formation of NPs. Furthermore, functional groups of the NPs were validated through Fourier-transform infrared spectroscopy (FT-IR). The measurement of zeta potential affirmed the stability of the as-prepared Fe 3 O 4 NPs, CDs, and CDs-Fe 3 O 4 NPs, indicating a value of −7.64 mV, −0.5754 mV and −3.881 mV, respectively. Fe 3 O 4 NPs exhibited a surface area of 58.6 m2/g as determined by Brunauer-Emmett-Teller (BET) analysis. The anticancer activity of the synthesized CDs-Fe 3 O 4 NPs demonstrated inhibition against MG-U87 cells. Therefore, the synthesized CDs-Fe 3 O 4 NPs hold potential for application in brain cancer therapy. In addition, CDs-Fe 3 O 4 NPs exhibited exceptional biocompatibility and low cytotoxicity against osteoblast cells, establishing them as a safe biomaterial for biomedical applications. [Display omitted] • Carbon dots (CDs) incorporated in Fe 3 O 4 nanoparticles (NPs) for targeted brain cancer therapy. • SEM images revealed the morphology of Fe 3 O 4 NPs is rough and agglomerated. • Magnetic properties evaluated using vibrating sample magnetometer (VSM) exhibited magnetization. • The measurement of zeta potential affirmed the stability of the as-prepared Fe 3 O 4 NPs, CDs, and CDs-Fe 3 O 4 NPs. • The synthesized CDs-Fe 3 O 4 NPs demonstrated inhibition against MG-U87 cells and good biocompatibility against osteoblast cells. [ABSTRACT FROM AUTHOR]
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Database: Engineering Source
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Abstract:Surface modification of magnetite (Fe 3 O 4) nanoparticles (NPs) using carbon dots (CDs) is a promising approach in biomedical applications due to excellent biocompatibility. Herein, the CDs were incorporated in the Fe 3 O 4 NPs to observe the performance of CDs-Fe 3 O 4 NPs for targeted brain cancer therapy. Scanning electron microscopy (SEM) images revealed the morphology of Fe 3 O 4 NPs is rough and agglomerated. X-ray diffraction (XRD) diffraction pattern exhibits that the CDs are successfully incorporated in Fe 3 O 4 NPs. Furthermore, magnetic properties evaluated using vibrating sample magnetometer (VSM) exhibited significant magnetization (51.362 emu/g) attributed to the greater occupancy of Fe+2 ions in the crystal lattice. XRD pattern confirmed the formation of NPs. Furthermore, functional groups of the NPs were validated through Fourier-transform infrared spectroscopy (FT-IR). The measurement of zeta potential affirmed the stability of the as-prepared Fe 3 O 4 NPs, CDs, and CDs-Fe 3 O 4 NPs, indicating a value of −7.64 mV, −0.5754 mV and −3.881 mV, respectively. Fe 3 O 4 NPs exhibited a surface area of 58.6 m2/g as determined by Brunauer-Emmett-Teller (BET) analysis. The anticancer activity of the synthesized CDs-Fe 3 O 4 NPs demonstrated inhibition against MG-U87 cells. Therefore, the synthesized CDs-Fe 3 O 4 NPs hold potential for application in brain cancer therapy. In addition, CDs-Fe 3 O 4 NPs exhibited exceptional biocompatibility and low cytotoxicity against osteoblast cells, establishing them as a safe biomaterial for biomedical applications. [Display omitted] • Carbon dots (CDs) incorporated in Fe 3 O 4 nanoparticles (NPs) for targeted brain cancer therapy. • SEM images revealed the morphology of Fe 3 O 4 NPs is rough and agglomerated. • Magnetic properties evaluated using vibrating sample magnetometer (VSM) exhibited magnetization. • The measurement of zeta potential affirmed the stability of the as-prepared Fe 3 O 4 NPs, CDs, and CDs-Fe 3 O 4 NPs. • The synthesized CDs-Fe 3 O 4 NPs demonstrated inhibition against MG-U87 cells and good biocompatibility against osteoblast cells. [ABSTRACT FROM AUTHOR]
ISSN:02540584
DOI:10.1016/j.matchemphys.2024.129698