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Hydrothermal synthesis of carbon dots incorporated in magnetite iron oxide nanoparticles for potential targeted brain cancer therapy: In-Vitro study.

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Title: Hydrothermal synthesis of carbon dots incorporated in magnetite iron oxide nanoparticles for potential targeted brain cancer therapy: In-Vitro study.
Authors: Yaqoob, Zahida1,2 (AUTHOR), Batool, Syeda Ammara2 (AUTHOR), Abdul Basit, Muhammad2 (AUTHOR), Konain, Kiran3 (AUTHOR), Malik, Rizwan Ahmed4 (AUTHOR), Rehman, Saeed Ur5 (AUTHOR), Hussain, Syed Wilayat2 (AUTHOR), Alrobei, Hussein1,4 (AUTHOR) H.alrobei@psau.edu.sa, Ur Rehman, Muhammad Atiq1 (AUTHOR)
Source: Materials Chemistry & Physics. Sep2024, Vol. 324, pN.PAG-N.PAG. 1p.
Subjects: Iron oxides, Brain cancer, Magnetite, Hydrothermal synthesis, Cancer treatment, Iron oxide nanoparticles, Cytocompatibility
Abstract: Surface modification of magnetite (Fe 3 O 4) nanoparticles (NPs) using carbon dots (CDs) is a promising approach in biomedical applications due to excellent biocompatibility. Herein, the CDs were incorporated in the Fe 3 O 4 NPs to observe the performance of CDs-Fe 3 O 4 NPs for targeted brain cancer therapy. Scanning electron microscopy (SEM) images revealed the morphology of Fe 3 O 4 NPs is rough and agglomerated. X-ray diffraction (XRD) diffraction pattern exhibits that the CDs are successfully incorporated in Fe 3 O 4 NPs. Furthermore, magnetic properties evaluated using vibrating sample magnetometer (VSM) exhibited significant magnetization (51.362 emu/g) attributed to the greater occupancy of Fe+2 ions in the crystal lattice. XRD pattern confirmed the formation of NPs. Furthermore, functional groups of the NPs were validated through Fourier-transform infrared spectroscopy (FT-IR). The measurement of zeta potential affirmed the stability of the as-prepared Fe 3 O 4 NPs, CDs, and CDs-Fe 3 O 4 NPs, indicating a value of −7.64 mV, −0.5754 mV and −3.881 mV, respectively. Fe 3 O 4 NPs exhibited a surface area of 58.6 m2/g as determined by Brunauer-Emmett-Teller (BET) analysis. The anticancer activity of the synthesized CDs-Fe 3 O 4 NPs demonstrated inhibition against MG-U87 cells. Therefore, the synthesized CDs-Fe 3 O 4 NPs hold potential for application in brain cancer therapy. In addition, CDs-Fe 3 O 4 NPs exhibited exceptional biocompatibility and low cytotoxicity against osteoblast cells, establishing them as a safe biomaterial for biomedical applications. [Display omitted] • Carbon dots (CDs) incorporated in Fe 3 O 4 nanoparticles (NPs) for targeted brain cancer therapy. • SEM images revealed the morphology of Fe 3 O 4 NPs is rough and agglomerated. • Magnetic properties evaluated using vibrating sample magnetometer (VSM) exhibited magnetization. • The measurement of zeta potential affirmed the stability of the as-prepared Fe 3 O 4 NPs, CDs, and CDs-Fe 3 O 4 NPs. • The synthesized CDs-Fe 3 O 4 NPs demonstrated inhibition against MG-U87 cells and good biocompatibility against osteoblast cells. [ABSTRACT FROM AUTHOR]
Copyright of Materials Chemistry & Physics is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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DbLabel: Engineering Source
An: 178599480
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  Data: Hydrothermal synthesis of carbon dots incorporated in magnetite iron oxide nanoparticles for potential targeted brain cancer therapy: In-Vitro study.
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  Data: <searchLink fieldCode="AR" term="%22Yaqoob%2C+Zahida%22">Yaqoob, Zahida</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Batool%2C+Syeda+Ammara%22">Batool, Syeda Ammara</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Abdul+Basit%2C+Muhammad%22">Abdul Basit, Muhammad</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Konain%2C+Kiran%22">Konain, Kiran</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Malik%2C+Rizwan+Ahmed%22">Malik, Rizwan Ahmed</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rehman%2C+Saeed+Ur%22">Rehman, Saeed Ur</searchLink><relatesTo>5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hussain%2C+Syed+Wilayat%22">Hussain, Syed Wilayat</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Alrobei%2C+Hussein%22">Alrobei, Hussein</searchLink><relatesTo>1,4</relatesTo> (AUTHOR)<i> H.alrobei@psau.edu.sa</i><br /><searchLink fieldCode="AR" term="%22Ur+Rehman%2C+Muhammad+Atiq%22">Ur Rehman, Muhammad Atiq</searchLink><relatesTo>1</relatesTo> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Materials+Chemistry+%26+Physics%22">Materials Chemistry & Physics</searchLink>. Sep2024, Vol. 324, pN.PAG-N.PAG. 1p.
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  Data: <searchLink fieldCode="DE" term="%22Iron+oxides%22">Iron oxides</searchLink><br /><searchLink fieldCode="DE" term="%22Brain+cancer%22">Brain cancer</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetite%22">Magnetite</searchLink><br /><searchLink fieldCode="DE" term="%22Hydrothermal+synthesis%22">Hydrothermal synthesis</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer+treatment%22">Cancer treatment</searchLink><br /><searchLink fieldCode="DE" term="%22Iron+oxide+nanoparticles%22">Iron oxide nanoparticles</searchLink><br /><searchLink fieldCode="DE" term="%22Cytocompatibility%22">Cytocompatibility</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Surface modification of magnetite (Fe 3 O 4) nanoparticles (NPs) using carbon dots (CDs) is a promising approach in biomedical applications due to excellent biocompatibility. Herein, the CDs were incorporated in the Fe 3 O 4 NPs to observe the performance of CDs-Fe 3 O 4 NPs for targeted brain cancer therapy. Scanning electron microscopy (SEM) images revealed the morphology of Fe 3 O 4 NPs is rough and agglomerated. X-ray diffraction (XRD) diffraction pattern exhibits that the CDs are successfully incorporated in Fe 3 O 4 NPs. Furthermore, magnetic properties evaluated using vibrating sample magnetometer (VSM) exhibited significant magnetization (51.362 emu/g) attributed to the greater occupancy of Fe+2 ions in the crystal lattice. XRD pattern confirmed the formation of NPs. Furthermore, functional groups of the NPs were validated through Fourier-transform infrared spectroscopy (FT-IR). The measurement of zeta potential affirmed the stability of the as-prepared Fe 3 O 4 NPs, CDs, and CDs-Fe 3 O 4 NPs, indicating a value of −7.64 mV, −0.5754 mV and −3.881 mV, respectively. Fe 3 O 4 NPs exhibited a surface area of 58.6 m2/g as determined by Brunauer-Emmett-Teller (BET) analysis. The anticancer activity of the synthesized CDs-Fe 3 O 4 NPs demonstrated inhibition against MG-U87 cells. Therefore, the synthesized CDs-Fe 3 O 4 NPs hold potential for application in brain cancer therapy. In addition, CDs-Fe 3 O 4 NPs exhibited exceptional biocompatibility and low cytotoxicity against osteoblast cells, establishing them as a safe biomaterial for biomedical applications. [Display omitted] • Carbon dots (CDs) incorporated in Fe 3 O 4 nanoparticles (NPs) for targeted brain cancer therapy. • SEM images revealed the morphology of Fe 3 O 4 NPs is rough and agglomerated. • Magnetic properties evaluated using vibrating sample magnetometer (VSM) exhibited magnetization. • The measurement of zeta potential affirmed the stability of the as-prepared Fe 3 O 4 NPs, CDs, and CDs-Fe 3 O 4 NPs. • The synthesized CDs-Fe 3 O 4 NPs demonstrated inhibition against MG-U87 cells and good biocompatibility against osteoblast cells. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
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  Data: <i>Copyright of Materials Chemistry & Physics is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1016/j.matchemphys.2024.129698
    Languages:
      – Code: eng
        Text: English
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        PageCount: 1
        StartPage: N.PAG
    Subjects:
      – SubjectFull: Iron oxides
        Type: general
      – SubjectFull: Brain cancer
        Type: general
      – SubjectFull: Magnetite
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      – SubjectFull: Hydrothermal synthesis
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      – SubjectFull: Cancer treatment
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      – SubjectFull: Iron oxide nanoparticles
        Type: general
      – SubjectFull: Cytocompatibility
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      – TitleFull: Hydrothermal synthesis of carbon dots incorporated in magnetite iron oxide nanoparticles for potential targeted brain cancer therapy: In-Vitro study.
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              Text: Sep2024
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