A glaucoma micro-stent with diverging channel and stepped shaft structure based on microfluidic template processing technology.
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| Title: | A glaucoma micro-stent with diverging channel and stepped shaft structure based on microfluidic template processing technology. |
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| Authors: | Wang, Chen1 (AUTHOR), Wang, Fule1 (AUTHOR), Liao, Yunru2,3 (AUTHOR), Zuo, Chengguo2 (AUTHOR), Lin, Mingkai2 (AUTHOR) linmk@mail.sysu.edu.cn, Wang, Kemin4 (AUTHOR), Ren, Dongni4 (AUTHOR), Zhang, Hongbo1 (AUTHOR), Yin, Ruixue1 (AUTHOR) yinruixue@ecust.edu.cn |
| Source: | BioMedical Engineering OnLine. 7/27/2024, Vol. 23 Issue 1, p1-22. 22p. |
| Subjects: | Surgical stents, Microfluidics, Glaucoma, Minimally invasive procedures, Stress concentration, Medical drainage, Cytotoxins |
| Abstract: | Background: Minimally invasive glaucoma surgery (MIGS) has experienced a surge in popularity in recent years. Glaucoma micro-stents serve as the foundation for these minimally invasive procedures. Nevertheless, the utilization of these stents still presents certain short-term and long-term complications. This study aims to elucidate the creation of a novel drainage stent implant featuring a diverging channel, produced through microfluidic template processing technology. Additionally, an analysis of the mechanical properties, biocompatibility, and feasibility of implantation is conducted. Results: The stress concentration value of the proposed stent is significantly lower, approximately two to three times smaller, compared to the currently available commercial XEN gel stent. This indicates a stronger resistance to bending in theory. Theoretical calculations further reveal that the initial drainage efficiency of the gradient diverging drainage stent is approximately 5.76 times higher than that of XEN stents. Notably, in vivo experiments conducted at the third month demonstrate a favorable biocompatibility profile without any observed cytotoxicity. Additionally, the drainage stent exhibits excellent material stability in an in vitro simulation environment. Conclusions: In summary, the diverging drainage stent presents a novel approach to the cost-effective and efficient preparation process of minimally invasive glaucoma surgery (MIGS) devices, offering additional filtering treatment options for glaucoma. [ABSTRACT FROM AUTHOR] |
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| Database: | Engineering Source |
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| Abstract: | Background: Minimally invasive glaucoma surgery (MIGS) has experienced a surge in popularity in recent years. Glaucoma micro-stents serve as the foundation for these minimally invasive procedures. Nevertheless, the utilization of these stents still presents certain short-term and long-term complications. This study aims to elucidate the creation of a novel drainage stent implant featuring a diverging channel, produced through microfluidic template processing technology. Additionally, an analysis of the mechanical properties, biocompatibility, and feasibility of implantation is conducted. Results: The stress concentration value of the proposed stent is significantly lower, approximately two to three times smaller, compared to the currently available commercial XEN gel stent. This indicates a stronger resistance to bending in theory. Theoretical calculations further reveal that the initial drainage efficiency of the gradient diverging drainage stent is approximately 5.76 times higher than that of XEN stents. Notably, in vivo experiments conducted at the third month demonstrate a favorable biocompatibility profile without any observed cytotoxicity. Additionally, the drainage stent exhibits excellent material stability in an in vitro simulation environment. Conclusions: In summary, the diverging drainage stent presents a novel approach to the cost-effective and efficient preparation process of minimally invasive glaucoma surgery (MIGS) devices, offering additional filtering treatment options for glaucoma. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 1475925X |
| DOI: | 10.1186/s12938-024-01266-4 |
