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A glaucoma micro-stent with diverging channel and stepped shaft structure based on microfluidic template processing technology.

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Title: A glaucoma micro-stent with diverging channel and stepped shaft structure based on microfluidic template processing technology.
Authors: Wang, Chen1 (AUTHOR), Wang, Fule1 (AUTHOR), Liao, Yunru2,3 (AUTHOR), Zuo, Chengguo2 (AUTHOR), Lin, Mingkai2 (AUTHOR) linmk@mail.sysu.edu.cn, Wang, Kemin4 (AUTHOR), Ren, Dongni4 (AUTHOR), Zhang, Hongbo1 (AUTHOR), Yin, Ruixue1 (AUTHOR) yinruixue@ecust.edu.cn
Source: BioMedical Engineering OnLine. 7/27/2024, Vol. 23 Issue 1, p1-22. 22p.
Subjects: Surgical stents, Microfluidics, Glaucoma, Minimally invasive procedures, Stress concentration, Medical drainage, Cytotoxins
Abstract: Background: Minimally invasive glaucoma surgery (MIGS) has experienced a surge in popularity in recent years. Glaucoma micro-stents serve as the foundation for these minimally invasive procedures. Nevertheless, the utilization of these stents still presents certain short-term and long-term complications. This study aims to elucidate the creation of a novel drainage stent implant featuring a diverging channel, produced through microfluidic template processing technology. Additionally, an analysis of the mechanical properties, biocompatibility, and feasibility of implantation is conducted. Results: The stress concentration value of the proposed stent is significantly lower, approximately two to three times smaller, compared to the currently available commercial XEN gel stent. This indicates a stronger resistance to bending in theory. Theoretical calculations further reveal that the initial drainage efficiency of the gradient diverging drainage stent is approximately 5.76 times higher than that of XEN stents. Notably, in vivo experiments conducted at the third month demonstrate a favorable biocompatibility profile without any observed cytotoxicity. Additionally, the drainage stent exhibits excellent material stability in an in vitro simulation environment. Conclusions: In summary, the diverging drainage stent presents a novel approach to the cost-effective and efficient preparation process of minimally invasive glaucoma surgery (MIGS) devices, offering additional filtering treatment options for glaucoma. [ABSTRACT FROM AUTHOR]
Copyright of BioMedical Engineering OnLine is the property of BioMed Central and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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Header DbId: egs
DbLabel: Engineering Source
An: 178621275
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PubType: Academic Journal
PubTypeId: academicJournal
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  Label: Title
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  Data: A glaucoma micro-stent with diverging channel and stepped shaft structure based on microfluidic template processing technology.
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  Data: <searchLink fieldCode="AR" term="%22Wang%2C+Chen%22">Wang, Chen</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wang%2C+Fule%22">Wang, Fule</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Liao%2C+Yunru%22">Liao, Yunru</searchLink><relatesTo>2,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zuo%2C+Chengguo%22">Zuo, Chengguo</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lin%2C+Mingkai%22">Lin, Mingkai</searchLink><relatesTo>2</relatesTo> (AUTHOR)<i> linmk@mail.sysu.edu.cn</i><br /><searchLink fieldCode="AR" term="%22Wang%2C+Kemin%22">Wang, Kemin</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ren%2C+Dongni%22">Ren, Dongni</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhang%2C+Hongbo%22">Zhang, Hongbo</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yin%2C+Ruixue%22">Yin, Ruixue</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> yinruixue@ecust.edu.cn</i>
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  Data: <searchLink fieldCode="JN" term="%22BioMedical+Engineering+OnLine%22">BioMedical Engineering OnLine</searchLink>. 7/27/2024, Vol. 23 Issue 1, p1-22. 22p.
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  Data: <searchLink fieldCode="DE" term="%22Surgical+stents%22">Surgical stents</searchLink><br /><searchLink fieldCode="DE" term="%22Microfluidics%22">Microfluidics</searchLink><br /><searchLink fieldCode="DE" term="%22Glaucoma%22">Glaucoma</searchLink><br /><searchLink fieldCode="DE" term="%22Minimally+invasive+procedures%22">Minimally invasive procedures</searchLink><br /><searchLink fieldCode="DE" term="%22Stress+concentration%22">Stress concentration</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+drainage%22">Medical drainage</searchLink><br /><searchLink fieldCode="DE" term="%22Cytotoxins%22">Cytotoxins</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background: Minimally invasive glaucoma surgery (MIGS) has experienced a surge in popularity in recent years. Glaucoma micro-stents serve as the foundation for these minimally invasive procedures. Nevertheless, the utilization of these stents still presents certain short-term and long-term complications. This study aims to elucidate the creation of a novel drainage stent implant featuring a diverging channel, produced through microfluidic template processing technology. Additionally, an analysis of the mechanical properties, biocompatibility, and feasibility of implantation is conducted. Results: The stress concentration value of the proposed stent is significantly lower, approximately two to three times smaller, compared to the currently available commercial XEN gel stent. This indicates a stronger resistance to bending in theory. Theoretical calculations further reveal that the initial drainage efficiency of the gradient diverging drainage stent is approximately 5.76 times higher than that of XEN stents. Notably, in vivo experiments conducted at the third month demonstrate a favorable biocompatibility profile without any observed cytotoxicity. Additionally, the drainage stent exhibits excellent material stability in an in vitro simulation environment. Conclusions: In summary, the diverging drainage stent presents a novel approach to the cost-effective and efficient preparation process of minimally invasive glaucoma surgery (MIGS) devices, offering additional filtering treatment options for glaucoma. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of BioMedical Engineering OnLine is the property of BioMed Central and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1186/s12938-024-01266-4
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      – Code: eng
        Text: English
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        PageCount: 22
        StartPage: 1
    Subjects:
      – SubjectFull: Surgical stents
        Type: general
      – SubjectFull: Microfluidics
        Type: general
      – SubjectFull: Glaucoma
        Type: general
      – SubjectFull: Minimally invasive procedures
        Type: general
      – SubjectFull: Stress concentration
        Type: general
      – SubjectFull: Medical drainage
        Type: general
      – SubjectFull: Cytotoxins
        Type: general
    Titles:
      – TitleFull: A glaucoma micro-stent with diverging channel and stepped shaft structure based on microfluidic template processing technology.
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              M: 07
              Text: 7/27/2024
              Type: published
              Y: 2024
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