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Calibration of scanning acoustic microscopy for the differentiation between unstable and stable atherosclerotic plaques by X-ray fluorescence imaging.

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Title: Calibration of scanning acoustic microscopy for the differentiation between unstable and stable atherosclerotic plaques by X-ray fluorescence imaging.
Authors: Modregger, Peter1,2 (AUTHOR) peter.modregger@uni-siegen.de, Khosla, Mallika1,2 (AUTHOR), Chakrabarti, Prerana1,2 (AUTHOR) prerana.chakrabarti@desy.de, Ozturk, Ozgul1 (AUTHOR) oezguel.oeztuerk@uni-siegen.de, Spiers, Kathryn M.3 (AUTHOR) kathryn.spiers@desy.de, Unlu, Mehmet Burcin4,5 (AUTHOR), Guvendiren, Bora6 (AUTHOR), Tanoren, Bukem1,7 (AUTHOR) bukem.tanoren@acibadem.edu.tr
Source: Radiation Physics & Chemistry. Nov2024, Vol. 224, pN.PAG-N.PAG. 1p.
Subjects: Acoustic microscopy, Atherosclerotic plaque, Acoustic impedance, X-ray imaging, Cardiological manifestations of general diseases
Abstract: Although cardiovascular diseases are the leading cause of death globally, un-stable atherosclerotic plaques play a vital role in plaque disruption which are related with multiple cardiovascular complications, but non-invasive and in-expensive diagnostic tools for the identification of associated unstable atheroscle-rotic plaques are not yet available. Scanning acoustic microscopy offers a high potential to fill this critical gap in patient care. However, convincing validation and calibration of this technique requires high-resolution maps of calcium concentrations of atherosclerotic plaques. In this preliminary study, a highly significant (p = 0.008) correlation between the median Ca concentra-tions and acoustic impedance values is displayed with a correlation coefficient of 0.96. Besides, we suggest that synchrotron radiation-based X-ray fluores-cence imaging with micrometer spatial resolution can provide such a gold standard for the calibration of scanning acoustic microscopy. Calibration of scanning acoustic microscopy for the differentiation between unstable and stable atherosclerotic plaques by X-ray flu- orescence imaging. [Display omitted] • Differentiation of unstable plaques with X-ray Fluorescence Microscopy. • Acoustic impedance mapping with Scanning Acoustic Microscopy. • Correlation between Acoustic Impedance and Ca Concentrations. [ABSTRACT FROM AUTHOR]
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Database: Engineering Source
Description
Abstract:Although cardiovascular diseases are the leading cause of death globally, un-stable atherosclerotic plaques play a vital role in plaque disruption which are related with multiple cardiovascular complications, but non-invasive and in-expensive diagnostic tools for the identification of associated unstable atheroscle-rotic plaques are not yet available. Scanning acoustic microscopy offers a high potential to fill this critical gap in patient care. However, convincing validation and calibration of this technique requires high-resolution maps of calcium concentrations of atherosclerotic plaques. In this preliminary study, a highly significant (p = 0.008) correlation between the median Ca concentra-tions and acoustic impedance values is displayed with a correlation coefficient of 0.96. Besides, we suggest that synchrotron radiation-based X-ray fluores-cence imaging with micrometer spatial resolution can provide such a gold standard for the calibration of scanning acoustic microscopy. Calibration of scanning acoustic microscopy for the differentiation between unstable and stable atherosclerotic plaques by X-ray flu- orescence imaging. [Display omitted] • Differentiation of unstable plaques with X-ray Fluorescence Microscopy. • Acoustic impedance mapping with Scanning Acoustic Microscopy. • Correlation between Acoustic Impedance and Ca Concentrations. [ABSTRACT FROM AUTHOR]
ISSN:0969806X
DOI:10.1016/j.radphyschem.2024.112058