Calibration of scanning acoustic microscopy for the differentiation between unstable and stable atherosclerotic plaques by X-ray fluorescence imaging.
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| Title: | Calibration of scanning acoustic microscopy for the differentiation between unstable and stable atherosclerotic plaques by X-ray fluorescence imaging. |
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| Authors: | Modregger, Peter1,2 (AUTHOR) peter.modregger@uni-siegen.de, Khosla, Mallika1,2 (AUTHOR), Chakrabarti, Prerana1,2 (AUTHOR) prerana.chakrabarti@desy.de, Ozturk, Ozgul1 (AUTHOR) oezguel.oeztuerk@uni-siegen.de, Spiers, Kathryn M.3 (AUTHOR) kathryn.spiers@desy.de, Unlu, Mehmet Burcin4,5 (AUTHOR), Guvendiren, Bora6 (AUTHOR), Tanoren, Bukem1,7 (AUTHOR) bukem.tanoren@acibadem.edu.tr |
| Source: | Radiation Physics & Chemistry. Nov2024, Vol. 224, pN.PAG-N.PAG. 1p. |
| Subjects: | Acoustic microscopy, Atherosclerotic plaque, Acoustic impedance, X-ray imaging, Cardiological manifestations of general diseases |
| Abstract: | Although cardiovascular diseases are the leading cause of death globally, un-stable atherosclerotic plaques play a vital role in plaque disruption which are related with multiple cardiovascular complications, but non-invasive and in-expensive diagnostic tools for the identification of associated unstable atheroscle-rotic plaques are not yet available. Scanning acoustic microscopy offers a high potential to fill this critical gap in patient care. However, convincing validation and calibration of this technique requires high-resolution maps of calcium concentrations of atherosclerotic plaques. In this preliminary study, a highly significant (p = 0.008) correlation between the median Ca concentra-tions and acoustic impedance values is displayed with a correlation coefficient of 0.96. Besides, we suggest that synchrotron radiation-based X-ray fluores-cence imaging with micrometer spatial resolution can provide such a gold standard for the calibration of scanning acoustic microscopy. Calibration of scanning acoustic microscopy for the differentiation between unstable and stable atherosclerotic plaques by X-ray flu- orescence imaging. [Display omitted] • Differentiation of unstable plaques with X-ray Fluorescence Microscopy. • Acoustic impedance mapping with Scanning Acoustic Microscopy. • Correlation between Acoustic Impedance and Ca Concentrations. [ABSTRACT FROM AUTHOR] |
| Copyright of Radiation Physics & Chemistry is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Text: Availability: 0 |
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| Header | DbId: egs DbLabel: Engineering Source An: 179107344 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Calibration of scanning acoustic microscopy for the differentiation between unstable and stable atherosclerotic plaques by X-ray fluorescence imaging. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Modregger%2C+Peter%22">Modregger, Peter</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> peter.modregger@uni-siegen.de</i><br /><searchLink fieldCode="AR" term="%22Khosla%2C+Mallika%22">Khosla, Mallika</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chakrabarti%2C+Prerana%22">Chakrabarti, Prerana</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> prerana.chakrabarti@desy.de</i><br /><searchLink fieldCode="AR" term="%22Ozturk%2C+Ozgul%22">Ozturk, Ozgul</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> oezguel.oeztuerk@uni-siegen.de</i><br /><searchLink fieldCode="AR" term="%22Spiers%2C+Kathryn+M%2E%22">Spiers, Kathryn M.</searchLink><relatesTo>3</relatesTo> (AUTHOR)<i> kathryn.spiers@desy.de</i><br /><searchLink fieldCode="AR" term="%22Unlu%2C+Mehmet+Burcin%22">Unlu, Mehmet Burcin</searchLink><relatesTo>4,5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Guvendiren%2C+Bora%22">Guvendiren, Bora</searchLink><relatesTo>6</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tanoren%2C+Bukem%22">Tanoren, Bukem</searchLink><relatesTo>1,7</relatesTo> (AUTHOR)<i> bukem.tanoren@acibadem.edu.tr</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Radiation+Physics+%26+Chemistry%22">Radiation Physics & Chemistry</searchLink>. Nov2024, Vol. 224, pN.PAG-N.PAG. 1p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Acoustic+microscopy%22">Acoustic microscopy</searchLink><br /><searchLink fieldCode="DE" term="%22Atherosclerotic+plaque%22">Atherosclerotic plaque</searchLink><br /><searchLink fieldCode="DE" term="%22Acoustic+impedance%22">Acoustic impedance</searchLink><br /><searchLink fieldCode="DE" term="%22X-ray+imaging%22">X-ray imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Cardiological+manifestations+of+general+diseases%22">Cardiological manifestations of general diseases</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Although cardiovascular diseases are the leading cause of death globally, un-stable atherosclerotic plaques play a vital role in plaque disruption which are related with multiple cardiovascular complications, but non-invasive and in-expensive diagnostic tools for the identification of associated unstable atheroscle-rotic plaques are not yet available. Scanning acoustic microscopy offers a high potential to fill this critical gap in patient care. However, convincing validation and calibration of this technique requires high-resolution maps of calcium concentrations of atherosclerotic plaques. In this preliminary study, a highly significant (p = 0.008) correlation between the median Ca concentra-tions and acoustic impedance values is displayed with a correlation coefficient of 0.96. Besides, we suggest that synchrotron radiation-based X-ray fluores-cence imaging with micrometer spatial resolution can provide such a gold standard for the calibration of scanning acoustic microscopy. Calibration of scanning acoustic microscopy for the differentiation between unstable and stable atherosclerotic plaques by X-ray flu- orescence imaging. [Display omitted] • Differentiation of unstable plaques with X-ray Fluorescence Microscopy. • Acoustic impedance mapping with Scanning Acoustic Microscopy. • Correlation between Acoustic Impedance and Ca Concentrations. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Radiation Physics & Chemistry is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.radphyschem.2024.112058 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 1 StartPage: N.PAG Subjects: – SubjectFull: Acoustic microscopy Type: general – SubjectFull: Atherosclerotic plaque Type: general – SubjectFull: Acoustic impedance Type: general – SubjectFull: X-ray imaging Type: general – SubjectFull: Cardiological manifestations of general diseases Type: general Titles: – TitleFull: Calibration of scanning acoustic microscopy for the differentiation between unstable and stable atherosclerotic plaques by X-ray fluorescence imaging. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Modregger, Peter – PersonEntity: Name: NameFull: Khosla, Mallika – PersonEntity: Name: NameFull: Chakrabarti, Prerana – PersonEntity: Name: NameFull: Ozturk, Ozgul – PersonEntity: Name: NameFull: Spiers, Kathryn M. – PersonEntity: Name: NameFull: Unlu, Mehmet Burcin – PersonEntity: Name: NameFull: Guvendiren, Bora – PersonEntity: Name: NameFull: Tanoren, Bukem IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 11 Text: Nov2024 Type: published Y: 2024 Identifiers: – Type: issn-print Value: 0969806X Numbering: – Type: volume Value: 224 Titles: – TitleFull: Radiation Physics & Chemistry Type: main |
| ResultId | 1 |
