View in EDS

Influence of emulsification conditions on the preparation of nanoparticle-stabilized antibubbles: High-shear homogenization versus premix membrane emulsification.

Saved in:
Bibliographic Details
Title: Influence of emulsification conditions on the preparation of nanoparticle-stabilized antibubbles: High-shear homogenization versus premix membrane emulsification.
Authors: Zia, Rabia1 (AUTHOR), Nazir, Akmal1,2 (AUTHOR) akmal.nazir@uaeu.ac.ae, Poortinga, Albert T.3 (AUTHOR), van Nostrum, Cornelus F.1 (AUTHOR) C.F.vanNostrum@uu.nl
Source: Colloids & Surfaces A: Physicochemical & Engineering Aspects. Nov2024, Vol. 701, pN.PAG-N.PAG. 1p.
Subjects: Silica nanoparticles, Manufacturing processes, Emulsions, Drug utilization, Nanoparticles
Abstract: Antibubbles, characterized by a water-in-air-in-water structure, are a novel dispersion system stabilized by the adsorption of nanoparticles (e.g., silica nanoparticles) at the air-liquid interface and produced via the emulsification-sublimation-rehydration technique. Traditionally, shear-based homogenization has been the standard method for creating Pickering double emulsions, which are then converted into particle-stabilized antibubbles. However, efficient drug delivery using antibubbles requires a small size, narrow size distribution, and high active loading, which are challenges typically faced with shear-based methods. This study introduces the formation of antibubbles using premix membrane emulsification (PME), a gentle technique ideal for heat- and shear-sensitive materials. We conducted a thorough investigation, producing primary and double emulsions with both high-shear homogenization (HSH) and PME through Shirasu porous glass (SPG) membranes. Antibubble size distribution and entrapment efficiency (using a model drug) were analyzed in relation to the process parameters of the emulsification techniques. We found that PME, particularly when using a 30 μm SPG membrane in the secondary emulsification stage, yielded antibubbles with smaller sizes (down to 5 μm in diameter) and significantly higher encapsulation efficiency (up to 80 %) compared to HSH. These findings highlight PME's potential as a superior method for producing nanoparticle-stabilized antibubbles for drug delivery applications. [Display omitted] • Comparison of HSH and PME in producing particle-stabilized antibubbles. • PME yields smaller antibubbles (∼5 µm) with higher encapsulation efficiency. • HSH shows significant entrapment loss during secondary emulsification. • PME is ideal for heat- and shear-sensitive material processing. • Selecting suitable emulsification techniques crucial for uniform antibubble size. [ABSTRACT FROM AUTHOR]
Copyright of Colloids & Surfaces A: Physicochemical & Engineering Aspects is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
Description
Abstract:Antibubbles, characterized by a water-in-air-in-water structure, are a novel dispersion system stabilized by the adsorption of nanoparticles (e.g., silica nanoparticles) at the air-liquid interface and produced via the emulsification-sublimation-rehydration technique. Traditionally, shear-based homogenization has been the standard method for creating Pickering double emulsions, which are then converted into particle-stabilized antibubbles. However, efficient drug delivery using antibubbles requires a small size, narrow size distribution, and high active loading, which are challenges typically faced with shear-based methods. This study introduces the formation of antibubbles using premix membrane emulsification (PME), a gentle technique ideal for heat- and shear-sensitive materials. We conducted a thorough investigation, producing primary and double emulsions with both high-shear homogenization (HSH) and PME through Shirasu porous glass (SPG) membranes. Antibubble size distribution and entrapment efficiency (using a model drug) were analyzed in relation to the process parameters of the emulsification techniques. We found that PME, particularly when using a 30 μm SPG membrane in the secondary emulsification stage, yielded antibubbles with smaller sizes (down to 5 μm in diameter) and significantly higher encapsulation efficiency (up to 80 %) compared to HSH. These findings highlight PME's potential as a superior method for producing nanoparticle-stabilized antibubbles for drug delivery applications. [Display omitted] • Comparison of HSH and PME in producing particle-stabilized antibubbles. • PME yields smaller antibubbles (∼5 µm) with higher encapsulation efficiency. • HSH shows significant entrapment loss during secondary emulsification. • PME is ideal for heat- and shear-sensitive material processing. • Selecting suitable emulsification techniques crucial for uniform antibubble size. [ABSTRACT FROM AUTHOR]
ISSN:09277757
DOI:10.1016/j.colsurfa.2024.134935