Visualization of Stress Fiber Formation Induced by Photodynamic Therapy with Porphylipoprotein.
Saved in:
| Title: | Visualization of Stress Fiber Formation Induced by Photodynamic Therapy with Porphylipoprotein. |
|---|---|
| Authors: | Taninaka, Atsushi1,2 (AUTHOR) jun_t@bk.tsukuba.ac.jp, Kurokawa, Hiromi3,4 (AUTHOR) hkurokawa.tt@md.tsukuba.ac.jp, Kamiyanagi, Mayuka1 (AUTHOR) kami.m.311007@gmail.com, Takeuchi, Osamu1 (AUTHOR) takeuchi.osamu.ft@u.tsukuba.ac.jp, Matsui, Hirofumi3 (AUTHOR) hmatsui@md.tsukuba.ac.jp, Shigekawa, Hidemi1 (AUTHOR) hidemi@ims.tsukuba.ac.jp |
| Source: | Nanomaterials (2079-4991). Dec2024, Vol. 14 Issue 23, p1862. 11p. |
| Subjects: | Atomic force microscopy, Photodynamic therapy, Elastic modulus, Confocal microscopy, Epithelial cells, Gastric mucosa |
| Abstract: | We investigated stress fiber formation induced by photodynamic therapy (PDT) with porphylipoprotein (PLP) by observing actin filaments by super-resolution confocal microscopy and measuring the cellular elastic modulus by atomic force microscopy. We identified different intracellular mechanisms of stress fiber formation between RGM1 epithelial cells, which were derived from rat gastric mucosa, and RGK1 cells, which were cancer-like mutants of RGM1. Our findings show that when PLP is used as a photosensitizer in PDT, it selectively induces necrosis in tumors with minimal impact on the surrounding normal tissues, as it is less likely to cause blood flow obstruction. [ABSTRACT FROM AUTHOR] |
| Copyright of Nanomaterials (2079-4991) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
|
Full text is not displayed to guests.
Login for full access.
|
|
| Abstract: | We investigated stress fiber formation induced by photodynamic therapy (PDT) with porphylipoprotein (PLP) by observing actin filaments by super-resolution confocal microscopy and measuring the cellular elastic modulus by atomic force microscopy. We identified different intracellular mechanisms of stress fiber formation between RGM1 epithelial cells, which were derived from rat gastric mucosa, and RGK1 cells, which were cancer-like mutants of RGM1. Our findings show that when PLP is used as a photosensitizer in PDT, it selectively induces necrosis in tumors with minimal impact on the surrounding normal tissues, as it is less likely to cause blood flow obstruction. [ABSTRACT FROM AUTHOR] |
|---|---|
| ISSN: | 20794991 |
| DOI: | 10.3390/nano14231862 |
