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Visualization of Stress Fiber Formation Induced by Photodynamic Therapy with Porphylipoprotein.

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Title: Visualization of Stress Fiber Formation Induced by Photodynamic Therapy with Porphylipoprotein.
Authors: Taninaka, Atsushi1,2 (AUTHOR) jun_t@bk.tsukuba.ac.jp, Kurokawa, Hiromi3,4 (AUTHOR) hkurokawa.tt@md.tsukuba.ac.jp, Kamiyanagi, Mayuka1 (AUTHOR) kami.m.311007@gmail.com, Takeuchi, Osamu1 (AUTHOR) takeuchi.osamu.ft@u.tsukuba.ac.jp, Matsui, Hirofumi3 (AUTHOR) hmatsui@md.tsukuba.ac.jp, Shigekawa, Hidemi1 (AUTHOR) hidemi@ims.tsukuba.ac.jp
Source: Nanomaterials (2079-4991). Dec2024, Vol. 14 Issue 23, p1862. 11p.
Subjects: Atomic force microscopy, Photodynamic therapy, Elastic modulus, Confocal microscopy, Epithelial cells, Gastric mucosa
Abstract: We investigated stress fiber formation induced by photodynamic therapy (PDT) with porphylipoprotein (PLP) by observing actin filaments by super-resolution confocal microscopy and measuring the cellular elastic modulus by atomic force microscopy. We identified different intracellular mechanisms of stress fiber formation between RGM1 epithelial cells, which were derived from rat gastric mucosa, and RGK1 cells, which were cancer-like mutants of RGM1. Our findings show that when PLP is used as a photosensitizer in PDT, it selectively induces necrosis in tumors with minimal impact on the surrounding normal tissues, as it is less likely to cause blood flow obstruction. [ABSTRACT FROM AUTHOR]
Copyright of Nanomaterials (2079-4991) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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Items – Name: Title
  Label: Title
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  Data: Visualization of Stress Fiber Formation Induced by Photodynamic Therapy with Porphylipoprotein.
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  Data: <searchLink fieldCode="AR" term="%22Taninaka%2C+Atsushi%22">Taninaka, Atsushi</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> jun_t@bk.tsukuba.ac.jp</i><br /><searchLink fieldCode="AR" term="%22Kurokawa%2C+Hiromi%22">Kurokawa, Hiromi</searchLink><relatesTo>3,4</relatesTo> (AUTHOR)<i> hkurokawa.tt@md.tsukuba.ac.jp</i><br /><searchLink fieldCode="AR" term="%22Kamiyanagi%2C+Mayuka%22">Kamiyanagi, Mayuka</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> kami.m.311007@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Takeuchi%2C+Osamu%22">Takeuchi, Osamu</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> takeuchi.osamu.ft@u.tsukuba.ac.jp</i><br /><searchLink fieldCode="AR" term="%22Matsui%2C+Hirofumi%22">Matsui, Hirofumi</searchLink><relatesTo>3</relatesTo> (AUTHOR)<i> hmatsui@md.tsukuba.ac.jp</i><br /><searchLink fieldCode="AR" term="%22Shigekawa%2C+Hidemi%22">Shigekawa, Hidemi</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> hidemi@ims.tsukuba.ac.jp</i>
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  Data: <searchLink fieldCode="JN" term="%22Nanomaterials+%282079-4991%29%22">Nanomaterials (2079-4991)</searchLink>. Dec2024, Vol. 14 Issue 23, p1862. 11p.
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  Data: <searchLink fieldCode="DE" term="%22Atomic+force+microscopy%22">Atomic force microscopy</searchLink><br /><searchLink fieldCode="DE" term="%22Photodynamic+therapy%22">Photodynamic therapy</searchLink><br /><searchLink fieldCode="DE" term="%22Elastic+modulus%22">Elastic modulus</searchLink><br /><searchLink fieldCode="DE" term="%22Confocal+microscopy%22">Confocal microscopy</searchLink><br /><searchLink fieldCode="DE" term="%22Epithelial+cells%22">Epithelial cells</searchLink><br /><searchLink fieldCode="DE" term="%22Gastric+mucosa%22">Gastric mucosa</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: We investigated stress fiber formation induced by photodynamic therapy (PDT) with porphylipoprotein (PLP) by observing actin filaments by super-resolution confocal microscopy and measuring the cellular elastic modulus by atomic force microscopy. We identified different intracellular mechanisms of stress fiber formation between RGM1 epithelial cells, which were derived from rat gastric mucosa, and RGK1 cells, which were cancer-like mutants of RGM1. Our findings show that when PLP is used as a photosensitizer in PDT, it selectively induces necrosis in tumors with minimal impact on the surrounding normal tissues, as it is less likely to cause blood flow obstruction. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Nanomaterials (2079-4991) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.3390/nano14231862
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      – Code: eng
        Text: English
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      Pagination:
        PageCount: 11
        StartPage: 1862
    Subjects:
      – SubjectFull: Atomic force microscopy
        Type: general
      – SubjectFull: Photodynamic therapy
        Type: general
      – SubjectFull: Elastic modulus
        Type: general
      – SubjectFull: Confocal microscopy
        Type: general
      – SubjectFull: Epithelial cells
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      – SubjectFull: Gastric mucosa
        Type: general
    Titles:
      – TitleFull: Visualization of Stress Fiber Formation Induced by Photodynamic Therapy with Porphylipoprotein.
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            NameFull: Taninaka, Atsushi
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            NameFull: Kurokawa, Hiromi
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            – D: 01
              M: 12
              Text: Dec2024
              Type: published
              Y: 2024
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