Equilibrium solubility and mathematical modelling of glibenclamide in cosolvent mixtures of glycols and alcohols.
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| Title: | Equilibrium solubility and mathematical modelling of glibenclamide in cosolvent mixtures of glycols and alcohols. |
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| Authors: | Nouri, Leila1,2 (AUTHOR), Rahimpour, Elaheh2,3 (AUTHOR) Rahimpour_e@yahoo.com, Jouyban, Abolghasem2,4 (AUTHOR) |
| Source: | Physics & Chemistry of Liquids. Jan2025, Vol. 63 Issue 1, p108-117. 10p. |
| Subjects: | Methoxyethanol, Hyperglycemia, Binary mixtures, Drug solubility, Atmospheric pressure |
| Abstract: | Glibenclamide (GBN) is a commonly used oral medication for treating type-II diabetes that acts by reducing high blood sugar levels. The effectiveness of GBN depends on the quality of the product. The quality is influenced by the solubility properties of a drug. This study aimed to measure the solubility of GBN in various solvent mixtures including some glycols and alcohols. The solubility was determined using a shake-flask method at 298.2 K under atmospheric pressure. The results showed that GBN had the highest solubility in ethylene glycol monomethyl ether and alcohol mixtures compared to the other tested glycols. [ABSTRACT FROM AUTHOR] |
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| Database: | Engineering Source |
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| Abstract: | Glibenclamide (GBN) is a commonly used oral medication for treating type-II diabetes that acts by reducing high blood sugar levels. The effectiveness of GBN depends on the quality of the product. The quality is influenced by the solubility properties of a drug. This study aimed to measure the solubility of GBN in various solvent mixtures including some glycols and alcohols. The solubility was determined using a shake-flask method at 298.2 K under atmospheric pressure. The results showed that GBN had the highest solubility in ethylene glycol monomethyl ether and alcohol mixtures compared to the other tested glycols. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 00319104 |
| DOI: | 10.1080/00319104.2024.2372559 |
