Equilibrium solubility and mathematical modelling of glibenclamide in cosolvent mixtures of glycols and alcohols.
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| Title: | Equilibrium solubility and mathematical modelling of glibenclamide in cosolvent mixtures of glycols and alcohols. |
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| Authors: | Nouri, Leila1,2 (AUTHOR), Rahimpour, Elaheh2,3 (AUTHOR) Rahimpour_e@yahoo.com, Jouyban, Abolghasem2,4 (AUTHOR) |
| Source: | Physics & Chemistry of Liquids. Jan2025, Vol. 63 Issue 1, p108-117. 10p. |
| Subjects: | Methoxyethanol, Hyperglycemia, Binary mixtures, Drug solubility, Atmospheric pressure |
| Abstract: | Glibenclamide (GBN) is a commonly used oral medication for treating type-II diabetes that acts by reducing high blood sugar levels. The effectiveness of GBN depends on the quality of the product. The quality is influenced by the solubility properties of a drug. This study aimed to measure the solubility of GBN in various solvent mixtures including some glycols and alcohols. The solubility was determined using a shake-flask method at 298.2 K under atmospheric pressure. The results showed that GBN had the highest solubility in ethylene glycol monomethyl ether and alcohol mixtures compared to the other tested glycols. [ABSTRACT FROM AUTHOR] |
| Copyright of Physics & Chemistry of Liquids is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
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| Header | DbId: egs DbLabel: Engineering Source An: 181985407 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Equilibrium solubility and mathematical modelling of glibenclamide in cosolvent mixtures of glycols and alcohols. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Nouri%2C+Leila%22">Nouri, Leila</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rahimpour%2C+Elaheh%22">Rahimpour, Elaheh</searchLink><relatesTo>2,3</relatesTo> (AUTHOR)<i> Rahimpour_e@yahoo.com</i><br /><searchLink fieldCode="AR" term="%22Jouyban%2C+Abolghasem%22">Jouyban, Abolghasem</searchLink><relatesTo>2,4</relatesTo> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Physics+%26+Chemistry+of+Liquids%22">Physics & Chemistry of Liquids</searchLink>. Jan2025, Vol. 63 Issue 1, p108-117. 10p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Methoxyethanol%22">Methoxyethanol</searchLink><br /><searchLink fieldCode="DE" term="%22Hyperglycemia%22">Hyperglycemia</searchLink><br /><searchLink fieldCode="DE" term="%22Binary+mixtures%22">Binary mixtures</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+solubility%22">Drug solubility</searchLink><br /><searchLink fieldCode="DE" term="%22Atmospheric+pressure%22">Atmospheric pressure</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Glibenclamide (GBN) is a commonly used oral medication for treating type-II diabetes that acts by reducing high blood sugar levels. The effectiveness of GBN depends on the quality of the product. The quality is influenced by the solubility properties of a drug. This study aimed to measure the solubility of GBN in various solvent mixtures including some glycols and alcohols. The solubility was determined using a shake-flask method at 298.2 K under atmospheric pressure. The results showed that GBN had the highest solubility in ethylene glycol monomethyl ether and alcohol mixtures compared to the other tested glycols. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Physics & Chemistry of Liquids is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1080/00319104.2024.2372559 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 10 StartPage: 108 Subjects: – SubjectFull: Methoxyethanol Type: general – SubjectFull: Hyperglycemia Type: general – SubjectFull: Binary mixtures Type: general – SubjectFull: Drug solubility Type: general – SubjectFull: Atmospheric pressure Type: general Titles: – TitleFull: Equilibrium solubility and mathematical modelling of glibenclamide in cosolvent mixtures of glycols and alcohols. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Nouri, Leila – PersonEntity: Name: NameFull: Rahimpour, Elaheh – PersonEntity: Name: NameFull: Jouyban, Abolghasem IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 01 Text: Jan2025 Type: published Y: 2025 Identifiers: – Type: issn-print Value: 00319104 Numbering: – Type: volume Value: 63 – Type: issue Value: 1 Titles: – TitleFull: Physics & Chemistry of Liquids Type: main |
| ResultId | 1 |
