Photobiomodulation and aquatic training reduce TNF-α expression and enhance muscle fiber area in Wistar rats with compensatory hypertrophy.
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| Title: | Photobiomodulation and aquatic training reduce TNF-α expression and enhance muscle fiber area in Wistar rats with compensatory hypertrophy. |
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| Authors: | Gregio, Valéria Araújo1 (AUTHOR), Martinelli, Andreia1 (AUTHOR), Malavazzi, Tainá Caroline dos Santos2 (AUTHOR), Andreo, Lucas2 (AUTHOR), Terena, Stella Maris Lins2 (AUTHOR), Bussadori, Sandra Kalil1,2 (AUTHOR), Marcos, Rodrigo Labat2 (AUTHOR), Horliana, Anna Carolina Ratto Tempestini2 (AUTHOR), Fernandes, Kristianne Porta Santos2 (AUTHOR), Mesquita-Ferrari, Raquel Agnelli1,2 (AUTHOR) raquel.mesquita@gmail.com |
| Source: | Lasers in Medical Science. 1/28/2025, Vol. 40 Issue 1, p1-11. 11p. |
| Subjects: | Photobiomodulation therapy, Hydrotherapy, Aquatic exercises, Laboratory rats, Body weight |
| Abstract: | This study aims to assess the effects of aquatic training (AT) and its combination with photobiomodulation (PBM) on cytokine synthesis and plantar muscle morphology during compensatory hypertrophy (H) in Wistar rats. H was induced by bilateral ablation of synergistic muscles, and PBM using a laser (780 nm). AT involved 60 min sessions, 5 times/week, for 7 and 14 days. Muscle weight relative to body weight did not differ significantly between groups. TNF-α synthesis levels decreased in the H + AT + PBM group at 7 days compared to H Control. IL-6 and IL-1β levels showed no significant changes. Cross-sectional area (CSA) was higher in H + AT + PBM at 7 days and 14 days compared to H + AT and H Control. Fiber diameter increased in H + AT and H + AT + PBM compared to H at 14 days. AT with PBM decreased TNF-α expression, increased CSA and fiber diameter, whereas AT alone increased fiber diameter. In conclusion, the combination of photobiomodulation (PBM) therapy and aquatic training (AT) effectively reduced TNF-α levels while increasing muscle fiber diameter and cross-sectional area (CSA). Furthermore, AT alone demonstrated the capacity to maintain fiber diameter. [ABSTRACT FROM AUTHOR] |
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| Database: | Engineering Source |
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| Abstract: | This study aims to assess the effects of aquatic training (AT) and its combination with photobiomodulation (PBM) on cytokine synthesis and plantar muscle morphology during compensatory hypertrophy (H) in Wistar rats. H was induced by bilateral ablation of synergistic muscles, and PBM using a laser (780 nm). AT involved 60 min sessions, 5 times/week, for 7 and 14 days. Muscle weight relative to body weight did not differ significantly between groups. TNF-α synthesis levels decreased in the H + AT + PBM group at 7 days compared to H Control. IL-6 and IL-1β levels showed no significant changes. Cross-sectional area (CSA) was higher in H + AT + PBM at 7 days and 14 days compared to H + AT and H Control. Fiber diameter increased in H + AT and H + AT + PBM compared to H at 14 days. AT with PBM decreased TNF-α expression, increased CSA and fiber diameter, whereas AT alone increased fiber diameter. In conclusion, the combination of photobiomodulation (PBM) therapy and aquatic training (AT) effectively reduced TNF-α levels while increasing muscle fiber diameter and cross-sectional area (CSA). Furthermore, AT alone demonstrated the capacity to maintain fiber diameter. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 02688921 |
| DOI: | 10.1007/s10103-025-04290-5 |
