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Design and biofabrication of barnacle and spider silk protein decorated composite bacterial cellulose for diabetic wound healing.

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Title: Design and biofabrication of barnacle and spider silk protein decorated composite bacterial cellulose for diabetic wound healing.
Authors: Ye, Luona1 (AUTHOR), Yan, Yunjun1 (AUTHOR) yanyunjun@hust.edu.cn, Yan, Jinyong1 (AUTHOR) yjiny@126.com
Source: Carbohydrate Polymers. Apr2025, Vol. 354, pN.PAG-N.PAG. 1p.
Subjects: Laboratory rats, Spider silk, Wound healing, Hyaluronic acid, Hydrogels, Bacterial diseases
Abstract: Delayed healing of wounds in diabetics is mainly due to tissue inflammation, poor vasculature, lack of neovascularization, and bacterial infection. Therefore, a therapeutic protocol that disrupts this cycle and speeds healing is urgently needed. Despite attempts to enhance wound dressing effectiveness through hydrogels with diverse complexes such as bacterial cellulose (BC) combined with chitosan, BC/ chitosan/hyaluronic acid, and BC/chitosan/collagen, the toughness and adhesion properties of hydrogel remain constrained, leading to inadequate and uncontrollable wound healing. To address the challenge, we have devised an innovative solution by integrating barnacle cement protein (cp19k) and spider silk protein (major ampullate spidroin 1, MaSp1) into a BC matrix, complemented by chitosan. This development has led to the creation of a novel BC-based composite hydrogel BC/cp19k-MaSp1/C 150k. The composite hydrogel stands out with its remarkable mechanical (3.92 Mpa) and adhesion properties (8.4 kPa) compared to its BC/C 150k counterpart. Meanwhile, the BC/cp19k-MaSp1/C 150k hydrogel also demonstrated antimicrobial activity, coagulation, and biocompatibility. The BC/cp19k-MaSp1/C 150k hydrogel showed an exceptional capacity to enhance wound healing in a diabetic rat model, achieving a significant wound closure rate of over 98 % on day 14 when compared to BC and commercially available dressing 3 M™ Tegaderm™. This advancement holds significant promise in revolutionizing wound management for diabetics. This study synthesized a BC-based nanocomplex hydrogel for diabetic wound healing. BC/cp19k-MaSp1/C 150k hydrogel showed strong mechanical and adhesion properties, antimicrobial activity, and enhanced wound healing in diabetic rats, indicating its potential as a biomedical dressing. [Display omitted] [ABSTRACT FROM AUTHOR]
Copyright of Carbohydrate Polymers is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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Header DbId: egs
DbLabel: Engineering Source
An: 183107499
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
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  Label: Title
  Group: Ti
  Data: Design and biofabrication of barnacle and spider silk protein decorated composite bacterial cellulose for diabetic wound healing.
– Name: Author
  Label: Authors
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  Data: <searchLink fieldCode="AR" term="%22Ye%2C+Luona%22">Ye, Luona</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yan%2C+Yunjun%22">Yan, Yunjun</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> yanyunjun@hust.edu.cn</i><br /><searchLink fieldCode="AR" term="%22Yan%2C+Jinyong%22">Yan, Jinyong</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> yjiny@126.com</i>
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  Data: <searchLink fieldCode="JN" term="%22Carbohydrate+Polymers%22">Carbohydrate Polymers</searchLink>. Apr2025, Vol. 354, pN.PAG-N.PAG. 1p.
– Name: Subject
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  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Laboratory+rats%22">Laboratory rats</searchLink><br /><searchLink fieldCode="DE" term="%22Spider+silk%22">Spider silk</searchLink><br /><searchLink fieldCode="DE" term="%22Wound+healing%22">Wound healing</searchLink><br /><searchLink fieldCode="DE" term="%22Hyaluronic+acid%22">Hyaluronic acid</searchLink><br /><searchLink fieldCode="DE" term="%22Hydrogels%22">Hydrogels</searchLink><br /><searchLink fieldCode="DE" term="%22Bacterial+diseases%22">Bacterial diseases</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Delayed healing of wounds in diabetics is mainly due to tissue inflammation, poor vasculature, lack of neovascularization, and bacterial infection. Therefore, a therapeutic protocol that disrupts this cycle and speeds healing is urgently needed. Despite attempts to enhance wound dressing effectiveness through hydrogels with diverse complexes such as bacterial cellulose (BC) combined with chitosan, BC/ chitosan/hyaluronic acid, and BC/chitosan/collagen, the toughness and adhesion properties of hydrogel remain constrained, leading to inadequate and uncontrollable wound healing. To address the challenge, we have devised an innovative solution by integrating barnacle cement protein (cp19k) and spider silk protein (major ampullate spidroin 1, MaSp1) into a BC matrix, complemented by chitosan. This development has led to the creation of a novel BC-based composite hydrogel BC/cp19k-MaSp1/C 150k. The composite hydrogel stands out with its remarkable mechanical (3.92 Mpa) and adhesion properties (8.4 kPa) compared to its BC/C 150k counterpart. Meanwhile, the BC/cp19k-MaSp1/C 150k hydrogel also demonstrated antimicrobial activity, coagulation, and biocompatibility. The BC/cp19k-MaSp1/C 150k hydrogel showed an exceptional capacity to enhance wound healing in a diabetic rat model, achieving a significant wound closure rate of over 98 % on day 14 when compared to BC and commercially available dressing 3 M™ Tegaderm™. This advancement holds significant promise in revolutionizing wound management for diabetics. This study synthesized a BC-based nanocomplex hydrogel for diabetic wound healing. BC/cp19k-MaSp1/C 150k hydrogel showed strong mechanical and adhesion properties, antimicrobial activity, and enhanced wound healing in diabetic rats, indicating its potential as a biomedical dressing. [Display omitted] [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Carbohydrate Polymers is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/j.carbpol.2025.123301
    Languages:
      – Code: eng
        Text: English
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        PageCount: 1
        StartPage: N.PAG
    Subjects:
      – SubjectFull: Laboratory rats
        Type: general
      – SubjectFull: Spider silk
        Type: general
      – SubjectFull: Wound healing
        Type: general
      – SubjectFull: Hyaluronic acid
        Type: general
      – SubjectFull: Hydrogels
        Type: general
      – SubjectFull: Bacterial diseases
        Type: general
    Titles:
      – TitleFull: Design and biofabrication of barnacle and spider silk protein decorated composite bacterial cellulose for diabetic wound healing.
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          Name:
            NameFull: Ye, Luona
      – PersonEntity:
          Name:
            NameFull: Yan, Yunjun
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            NameFull: Yan, Jinyong
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            – D: 15
              M: 04
              Text: Apr2025
              Type: published
              Y: 2025
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              Value: 354
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            – TitleFull: Carbohydrate Polymers
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