View in EDS

Traffic light at DSB–transit regulation between gene transcription and DNA repair.

Saved in:
Bibliographic Details
Title: Traffic light at DSB–transit regulation between gene transcription and DNA repair.
Authors: Modafferi, Stefania1,2 (AUTHOR), Esposito, Francesca1,3 (AUTHOR), Tavella, Sara1,4 (AUTHOR), Gioia, Ubaldo1,4 (AUTHOR) ubaldo.gioia@igm.cnr.it, Francia, Sofia1,4 (AUTHOR) sofia.francia@igm.cnr.it
Source: FEBS Letters. Jan2025, Vol. 599 Issue 2, p177-189. 13p.
Subjects: DNA repair, Double-strand DNA breaks, Genetic transcription, Non-coding RNA, Chromatin, Gene silencing
Abstract: Transcription of actively expressed genes is dampened for kilobases around DNA lesions via chromatin modifications. This is believed to favour repair and prevent genome instability. Nonetheless, mounting evidence suggests that transcription may be induced by DNA breakage, resulting in the local de novo synthesis of non‐coding RNAs (ncRNAs). Such transcripts have been proposed to play important functions in both DNA damage signalling and repair. Here, we review the recently identified mechanistic details of transcriptional silencing at damaged chromatin, highlighting how post‐translational histone modifications can also be modulated by the local synthesis of DNA damage‐induced ncRNAs. Finally, we envision that these entangled transcriptional events at DNA breakages can be targeted to modulate DNA repair, with potential implications for locus‐specific therapeutic strategies. [ABSTRACT FROM AUTHOR]
Copyright of FEBS Letters is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
Description
Abstract:Transcription of actively expressed genes is dampened for kilobases around DNA lesions via chromatin modifications. This is believed to favour repair and prevent genome instability. Nonetheless, mounting evidence suggests that transcription may be induced by DNA breakage, resulting in the local de novo synthesis of non‐coding RNAs (ncRNAs). Such transcripts have been proposed to play important functions in both DNA damage signalling and repair. Here, we review the recently identified mechanistic details of transcriptional silencing at damaged chromatin, highlighting how post‐translational histone modifications can also be modulated by the local synthesis of DNA damage‐induced ncRNAs. Finally, we envision that these entangled transcriptional events at DNA breakages can be targeted to modulate DNA repair, with potential implications for locus‐specific therapeutic strategies. [ABSTRACT FROM AUTHOR]
ISSN:00145793
DOI:10.1002/1873-3468.15024