Rheological Behavior of Fluid Within the Pore Space of Trabecular Bone.
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| Title: | Rheological Behavior of Fluid Within the Pore Space of Trabecular Bone. |
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| Authors: | Benhmida, Saida1,2,3 (AUTHOR) benhmidasaida@gmail.com, Zrida, Montassar2,4 (AUTHOR), Salhi, Dorra1 (AUTHOR), Ben Hatira, Fafa5 (AUTHOR), Trabelsi, Hedi1 (AUTHOR), Mahjoubi, Halima1 (AUTHOR) |
| Source: | JOM: The Journal of The Minerals, Metals & Materials Society (TMS). Jun2025, Vol. 77 Issue 6, p4260-4272. 13p. |
| Subjects: | Properties of fluids, Dynamic viscosity, Rheology, Non-Newtonian fluids, Bone remodeling |
| Abstract: | The rheological behavior of bone fluid within trabecular porous spaces plays a crucial role in mechanotransduction and, consequently, in bone remodeling. However, most models do not represent its physiological nature. This research aims to characterize the rheological properties of bone fluid flow. Fresh bone samples were harvested from human knees with osteoarthritis (OA), and subjected to tests to evaluate their viscosity using a rheometer. This study revealed that the dynamic viscosity of the fluid varied with time and shear rate, indicating non-Newtonian fluid behavior. Modeling was performed using the power-law model in Python. The power-law model applied in this study proved highly effective in describing the rheological behavior of bone fluid. The fit showed remarkable precision, with a coefficient of determination R2 = 0.9995, highlighting the excellent agreement between the experimental data and the model. These results suggest that variations in bone fluid viscosity, induced by mechanical stresses, could modulate osteocyte stimulation and influence bone remodeling in the context of OA. This research represents a significant advance in the understanding of bone fluid, and the knowledge gained could be fundamental for developing new therapeutic strategies in tissue engineering and regenerative medicine. [ABSTRACT FROM AUTHOR] |
| Copyright of JOM: The Journal of The Minerals, Metals & Materials Society (TMS) is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
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| Abstract: | The rheological behavior of bone fluid within trabecular porous spaces plays a crucial role in mechanotransduction and, consequently, in bone remodeling. However, most models do not represent its physiological nature. This research aims to characterize the rheological properties of bone fluid flow. Fresh bone samples were harvested from human knees with osteoarthritis (OA), and subjected to tests to evaluate their viscosity using a rheometer. This study revealed that the dynamic viscosity of the fluid varied with time and shear rate, indicating non-Newtonian fluid behavior. Modeling was performed using the power-law model in Python. The power-law model applied in this study proved highly effective in describing the rheological behavior of bone fluid. The fit showed remarkable precision, with a coefficient of determination R2 = 0.9995, highlighting the excellent agreement between the experimental data and the model. These results suggest that variations in bone fluid viscosity, induced by mechanical stresses, could modulate osteocyte stimulation and influence bone remodeling in the context of OA. This research represents a significant advance in the understanding of bone fluid, and the knowledge gained could be fundamental for developing new therapeutic strategies in tissue engineering and regenerative medicine. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 10474838 |
| DOI: | 10.1007/s11837-025-07291-5 |
