Bibliographic Details
| Title: |
Pyrazol-3-yldiazonium Salts as Key Reagents for C–C Bond Formation and Pyrazole-Containing Heterocycle Synthesis. |
| Authors: |
Barabash, Oksana V.1 (AUTHOR), Ostapiuk, Mary Y.1 (AUTHOR), Kravets, Mykola2 (AUTHOR), Obushak, Mykola D.1 (AUTHOR), Schmidt, Andreas3 (AUTHOR) schmidt@ioc.tu-clausthal.de, Ostapiuk, Yurii V.1 (AUTHOR) y.ostapiuk@gmail.com |
| Source: |
Synthesis. Aug2025, Vol. 57 Issue 15, p2351-2362. 12p. |
| Subjects: |
Pyrazolyl compounds, Heterocyclic compounds, Organic reaction mechanisms, Functional groups, Coupling reactions (Chemistry), Pyrazolates, Nucleophiles, Ring formation (Chemistry) |
| Abstract: |
A novel application of 1-methylpyrazol-3-yldiazonium salts in the Meerwein reaction was introduced. These diazonium salts reacted with α,β-unsaturated functionalized compounds under Meerwein reaction conditions to yield pyrazole-containing building blocks, which subsequently allowed cyclization reactions with bisnucleophiles for the synthesis of pyrazol-3-yl-containing heterocyclic systems. In this way, pyrazole-containing heterocyclic compounds with 2-aminothiazole, 2-aminoselenazole, thiazolidin-4-one, selenazolidin-4-one, 3-hydroxythiophene, and 3-aminothiophene rings were efficiently prepared. [ABSTRACT FROM AUTHOR] |
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| Database: |
Engineering Source |
