Metal-Free Synthesis of 1-(α-Hydroxyindole)- o -carboranes in Neat.
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| Title: | Metal-Free Synthesis of 1-(α-Hydroxyindole)- o -carboranes in Neat. |
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| Authors: | Zhang, Lin-Gen1 (AUTHOR), Yuan, Wen2 (AUTHOR), Yan, Shunsheng3 (AUTHOR) caoke@swust.edu.cn, Cao, Ke1 (AUTHOR) aiofmyss@163.com |
| Source: | Synthesis. Aug2025, Vol. 57 Issue 16, p2490-2495. 6p. |
| Subjects: | Friedel-Crafts reaction, Indole compounds, Sustainable chemistry, Lewis acids, Indole derivatives |
| Abstract: | An efficient and environmentally friendly protocol for the synthesis of 1-(α-hydroxyindole)- o -carboranes has been developed via Friedel–Crafts reaction of C3-H of indoles with 1-formyl- o -carborane in the absence of Lewis acid and solvent. The intermolecular σ-π interaction between indole and B–H bonds of o -carborane was proposed for promoting the Friedel–Crafts reaction of the C3-H of indole. [ABSTRACT FROM AUTHOR] |
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| Database: | Engineering Source |
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