Reconsidering gadolinium in long-term glioma follow-up: is contrast always and unquestionably necessary?

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Title: Reconsidering gadolinium in long-term glioma follow-up: is contrast always and unquestionably necessary?
Authors: Naval-Baudin, Pablo1,2,3,4 (AUTHOR) pablo.naval.idi@gencat.cat, Pons-Escoda, Albert1,2,3,5 (AUTHOR)
Source: European Radiology. Sep2025, Vol. 35 Issue 9, p5203-5205. 3p.
Subjects: Gadolinium, Gliomas, Magnetic resonance imaging, Imaging systems, Diagnostic imaging, Tumor growth
Abstract: The article discusses the evolving standards for monitoring adult-type diffuse gliomas using MRI, particularly the reliance on gadolinium-enhanced T1-weighted sequences (CET1w) versus non-contrast T2-weighted/FLAIR sequences. Recent findings from a multicenter study suggest that T2w/FLAIR abnormalities can effectively detect tumor progression, often earlier than gadolinium enhancement, raising questions about the necessity of gadolinium in certain cases, especially for long-term survivors of low-grade gliomas. The authors advocate for a balanced approach that utilizes T2w/FLAIR as an initial assessment tool, reserving gadolinium for cases where abnormalities are detected, thereby addressing concerns about gadolinium's safety, cost, and environmental impact. The article emphasizes the need for further research to refine imaging protocols and explore advanced non-contrast techniques in glioma management. [Extracted from the article]
Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Reconsidering gadolinium in long-term glioma follow-up: is contrast always and unquestionably necessary?
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  Data: <searchLink fieldCode="AR" term="%22Naval-Baudin%2C+Pablo%22">Naval-Baudin, Pablo</searchLink><relatesTo>1,2,3,4</relatesTo> (AUTHOR)<i> pablo.naval.idi@gencat.cat</i><br /><searchLink fieldCode="AR" term="%22Pons-Escoda%2C+Albert%22">Pons-Escoda, Albert</searchLink><relatesTo>1,2,3,5</relatesTo> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22European+Radiology%22">European Radiology</searchLink>. Sep2025, Vol. 35 Issue 9, p5203-5205. 3p.
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  Data: <searchLink fieldCode="DE" term="%22Gadolinium%22">Gadolinium</searchLink><br /><searchLink fieldCode="DE" term="%22Gliomas%22">Gliomas</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetic+resonance+imaging%22">Magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Imaging+systems%22">Imaging systems</searchLink><br /><searchLink fieldCode="DE" term="%22Diagnostic+imaging%22">Diagnostic imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Tumor+growth%22">Tumor growth</searchLink>
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  Label: Abstract
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  Data: The article discusses the evolving standards for monitoring adult-type diffuse gliomas using MRI, particularly the reliance on gadolinium-enhanced T1-weighted sequences (CET1w) versus non-contrast T2-weighted/FLAIR sequences. Recent findings from a multicenter study suggest that T2w/FLAIR abnormalities can effectively detect tumor progression, often earlier than gadolinium enhancement, raising questions about the necessity of gadolinium in certain cases, especially for long-term survivors of low-grade gliomas. The authors advocate for a balanced approach that utilizes T2w/FLAIR as an initial assessment tool, reserving gadolinium for cases where abnormalities are detected, thereby addressing concerns about gadolinium's safety, cost, and environmental impact. The article emphasizes the need for further research to refine imaging protocols and explore advanced non-contrast techniques in glioma management. [Extracted from the article]
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  Data: <i>Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1007/s00330-025-11504-5
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      – Code: eng
        Text: English
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    Subjects:
      – SubjectFull: Gadolinium
        Type: general
      – SubjectFull: Gliomas
        Type: general
      – SubjectFull: Magnetic resonance imaging
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      – SubjectFull: Imaging systems
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      – SubjectFull: Diagnostic imaging
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      – SubjectFull: Tumor growth
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      – TitleFull: Reconsidering gadolinium in long-term glioma follow-up: is contrast always and unquestionably necessary?
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              M: 09
              Text: Sep2025
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              Y: 2025
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