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Carborane-Containing Iron Oxide@Gold Nanoparticles for Potential Application in Neutron Capture Therapy.

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Title: Carborane-Containing Iron Oxide@Gold Nanoparticles for Potential Application in Neutron Capture Therapy.
Authors: Bekbol, Zhangali A.1,2 (AUTHOR), Izbasar, Kairat A.1,2 (AUTHOR), Zaboronok, Alexander1,3 (AUTHOR) i.korolkov@inp.kz, Lissovskaya, Lana I.1,2,4 (AUTHOR), Yang, Haolan1,3 (AUTHOR), Pihosh, Yuriy2,4 (AUTHOR), Ishikawa, Eiichi3 (AUTHOR), Shakirzyanov, Rafael I.2,4 (AUTHOR), Korolkov, Ilya V.1,2 (AUTHOR)
Source: Nanomaterials (2079-4991). Aug2025, Vol. 15 Issue 16, p1243. 20p.
Subjects: Boron-neutron capture therapy, Cancer treatment, Nanomedicine, Carboranes, Ferric oxide, Gold nanoparticles, Neutron capture, Nanoparticles
Abstract: Cancer remains one of the most pressing global health challenges, driving the need for innovative treatment strategies. Boron neutron capture therapy (BNCT) offers a highly selective approach to destroying cancer cells while sparing healthy tissues. To improve boron delivery, Fe3O4@Au nanoparticles were developed and functionalized with a boron-containing carborane compound. Fe3O4 nanoparticles were synthesized and covered by gold, followed by (3-Aminopropyl)triethoxysilane (APTES) modification to introduce amino groups for carborane immobilization. Comprehensive characterization using SEM, DLS, FTIR, EDX, Brunauer–Emmett–Teller (BET), and XRD confirmed successful functionalization at each stage. TEM confirmed the final structure and elemental composition of the nanoparticles. BET analysis revealed a surface area of 94.69 m2/g and a pore volume of 0.51 cm3/g after carborane loading. Initial release studies in PBS demonstrated the removal of only loosely bound carborane within 48 h, with FTIR confirming stable retention of the compound on the nanoparticle surface. The modified nanoparticles achieved a stable zeta potential of −20 mV. The particles showed low toxicity within a range of concentrations (0–300 μg Fe/mL) and were efficiently accumulated by U251MG cells. These results demonstrate the potential of the obtained nanoparticles to carry boron and gold for their possible application as a theranostic agent. [ABSTRACT FROM AUTHOR]
Copyright of Nanomaterials (2079-4991) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Label: Title
  Group: Ti
  Data: Carborane-Containing Iron Oxide@Gold Nanoparticles for Potential Application in Neutron Capture Therapy.
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  Data: <searchLink fieldCode="AR" term="%22Bekbol%2C+Zhangali+A%2E%22">Bekbol, Zhangali A.</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Izbasar%2C+Kairat+A%2E%22">Izbasar, Kairat A.</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zaboronok%2C+Alexander%22">Zaboronok, Alexander</searchLink><relatesTo>1,3</relatesTo> (AUTHOR)<i> i.korolkov@inp.kz</i><br /><searchLink fieldCode="AR" term="%22Lissovskaya%2C+Lana+I%2E%22">Lissovskaya, Lana I.</searchLink><relatesTo>1,2,4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yang%2C+Haolan%22">Yang, Haolan</searchLink><relatesTo>1,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pihosh%2C+Yuriy%22">Pihosh, Yuriy</searchLink><relatesTo>2,4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ishikawa%2C+Eiichi%22">Ishikawa, Eiichi</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Shakirzyanov%2C+Rafael+I%2E%22">Shakirzyanov, Rafael I.</searchLink><relatesTo>2,4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Korolkov%2C+Ilya+V%2E%22">Korolkov, Ilya V.</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)
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  Data: <searchLink fieldCode="DE" term="%22Boron-neutron+capture+therapy%22">Boron-neutron capture therapy</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer+treatment%22">Cancer treatment</searchLink><br /><searchLink fieldCode="DE" term="%22Nanomedicine%22">Nanomedicine</searchLink><br /><searchLink fieldCode="DE" term="%22Carboranes%22">Carboranes</searchLink><br /><searchLink fieldCode="DE" term="%22Ferric+oxide%22">Ferric oxide</searchLink><br /><searchLink fieldCode="DE" term="%22Gold+nanoparticles%22">Gold nanoparticles</searchLink><br /><searchLink fieldCode="DE" term="%22Neutron+capture%22">Neutron capture</searchLink><br /><searchLink fieldCode="DE" term="%22Nanoparticles%22">Nanoparticles</searchLink>
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  Label: Abstract
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  Data: Cancer remains one of the most pressing global health challenges, driving the need for innovative treatment strategies. Boron neutron capture therapy (BNCT) offers a highly selective approach to destroying cancer cells while sparing healthy tissues. To improve boron delivery, Fe3O4@Au nanoparticles were developed and functionalized with a boron-containing carborane compound. Fe3O4 nanoparticles were synthesized and covered by gold, followed by (3-Aminopropyl)triethoxysilane (APTES) modification to introduce amino groups for carborane immobilization. Comprehensive characterization using SEM, DLS, FTIR, EDX, Brunauer–Emmett–Teller (BET), and XRD confirmed successful functionalization at each stage. TEM confirmed the final structure and elemental composition of the nanoparticles. BET analysis revealed a surface area of 94.69 m2/g and a pore volume of 0.51 cm3/g after carborane loading. Initial release studies in PBS demonstrated the removal of only loosely bound carborane within 48 h, with FTIR confirming stable retention of the compound on the nanoparticle surface. The modified nanoparticles achieved a stable zeta potential of −20 mV. The particles showed low toxicity within a range of concentrations (0–300 μg Fe/mL) and were efficiently accumulated by U251MG cells. These results demonstrate the potential of the obtained nanoparticles to carry boron and gold for their possible application as a theranostic agent. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Nanomaterials (2079-4991) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.3390/nano15161243
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        Text: English
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        StartPage: 1243
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      – SubjectFull: Boron-neutron capture therapy
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      – SubjectFull: Cancer treatment
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      – SubjectFull: Nanomedicine
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      – SubjectFull: Carboranes
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      – SubjectFull: Gold nanoparticles
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      – SubjectFull: Neutron capture
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              Text: Aug2025
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