Initial experience of cardiac T1ρ mapping at 0.55 T: Continuous wave versus adiabatic spin‐lock preparation pulses.
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| Title: | Initial experience of cardiac T |
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| Authors: | Si, Dongyue1 (AUTHOR), Crabb, Michael G.1 (AUTHOR), Littlewood, Simon J.1 (AUTHOR), Kunze, Karl P.1,2 (AUTHOR), Varghese, Juliet3 (AUTHOR), Binzel, Katherine4 (AUTHOR), Khan, Mahmood4,5 (AUTHOR), Simonetti, Orlando P.4,6,7 (AUTHOR), Prieto, Claudia1,8,9 (AUTHOR), Botnar, René M.1,8,9,10,11 (AUTHOR) rene.botnar@kcl.ac.uk |
| Source: | Magnetic Resonance in Medicine. Oct2025, Vol. 94 Issue 4, p1644-1653. 10p. |
| Subjects: | Hypertrophic cardiomyopathy, Cardiac imaging, Diagnostic imaging, Myocardial infarction, Pulse (Heart beat) |
| Abstract: | Purpose: To propose and validate a cardiac T1ρ mapping sequence at 0.55 T comparing continuous‐wave and adiabatic spin‐lock (SL) preparation pulses. Methods: The proposed 2D sequence acquires four single‐shot balanced SSFP readout images with differing contrasts in a single breath‐hold. The first three images are prepared with T1ρ preparation pulses with different durations, while the last image uses a saturation pulse immediately before data acquisition. The T1ρ map is calculated using a 3‐parameter fitting method. Bloch equation simulations were performed to optimize the parameters of the adiabatic‐SL pulses. Phantom studies and in vivo experiments in 10 healthy volunteers, a porcine myocardial infarction model, and a patient with suspected hypertrophic cardiomyopathy were performed to validate the performance of the proposed adiabatic T1ρ (T1ρAd) mapping in comparison with conventional continuous‐wave T1ρ (T1ρCW) mapping. Results: The adiabatic‐SL pulse with simulation‐optimized parameters demonstrated robust performance despite B0 and B1 field inhomogeneities. Phantom T1ρCW and T1ρAd mapping exhibited comparable precision. In vivo experiments on healthy volunteers showed that myocardial T1ρAd is higher than T1ρCW (106.1 ± 7.1 vs. 47.0 ± 5.1 ms, p < 0.01) with better precision (11.4% ± 2.6% vs. 14.5% ± 2.1%, p < 0.01) and less spatial variation (10.9% ± 3.0% vs. 14.4% ± 3.4%, p < 0.01). Both T1ρCW and T1ρAd mapping agreed with late gadolinium enhancement findings in the porcine model and the patient, and exhibited improved contrast compared to T1 and T2 mapping. Conclusion: Both T1ρCW and T1ρAd are promising for non‐contrast detection of various cardiomyopathies at 0.55 T, but T1ρAd demonstrates better spatial uniformity than T1ρCW. [ABSTRACT FROM AUTHOR] |
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| Database: | Engineering Source |
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| Abstract: | Purpose: To propose and validate a cardiac T1ρ mapping sequence at 0.55 T comparing continuous‐wave and adiabatic spin‐lock (SL) preparation pulses. Methods: The proposed 2D sequence acquires four single‐shot balanced SSFP readout images with differing contrasts in a single breath‐hold. The first three images are prepared with T1ρ preparation pulses with different durations, while the last image uses a saturation pulse immediately before data acquisition. The T1ρ map is calculated using a 3‐parameter fitting method. Bloch equation simulations were performed to optimize the parameters of the adiabatic‐SL pulses. Phantom studies and in vivo experiments in 10 healthy volunteers, a porcine myocardial infarction model, and a patient with suspected hypertrophic cardiomyopathy were performed to validate the performance of the proposed adiabatic T1ρ (T1ρAd) mapping in comparison with conventional continuous‐wave T1ρ (T1ρCW) mapping. Results: The adiabatic‐SL pulse with simulation‐optimized parameters demonstrated robust performance despite B0 and B1 field inhomogeneities. Phantom T1ρCW and T1ρAd mapping exhibited comparable precision. In vivo experiments on healthy volunteers showed that myocardial T1ρAd is higher than T1ρCW (106.1 ± 7.1 vs. 47.0 ± 5.1 ms, p < 0.01) with better precision (11.4% ± 2.6% vs. 14.5% ± 2.1%, p < 0.01) and less spatial variation (10.9% ± 3.0% vs. 14.4% ± 3.4%, p < 0.01). Both T1ρCW and T1ρAd mapping agreed with late gadolinium enhancement findings in the porcine model and the patient, and exhibited improved contrast compared to T1 and T2 mapping. Conclusion: Both T1ρCW and T1ρAd are promising for non‐contrast detection of various cardiomyopathies at 0.55 T, but T1ρAd demonstrates better spatial uniformity than T1ρCW. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 07403194 |
| DOI: | 10.1002/mrm.30582 |
