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Initial experience of cardiac T1ρ mapping at 0.55 T: Continuous wave versus adiabatic spin‐lock preparation pulses.

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Title: Initial experience of cardiac T1ρ mapping at 0.55 T: Continuous wave versus adiabatic spin‐lock preparation pulses.
Authors: Si, Dongyue1 (AUTHOR), Crabb, Michael G.1 (AUTHOR), Littlewood, Simon J.1 (AUTHOR), Kunze, Karl P.1,2 (AUTHOR), Varghese, Juliet3 (AUTHOR), Binzel, Katherine4 (AUTHOR), Khan, Mahmood4,5 (AUTHOR), Simonetti, Orlando P.4,6,7 (AUTHOR), Prieto, Claudia1,8,9 (AUTHOR), Botnar, René M.1,8,9,10,11 (AUTHOR) rene.botnar@kcl.ac.uk
Source: Magnetic Resonance in Medicine. Oct2025, Vol. 94 Issue 4, p1644-1653. 10p.
Subjects: Hypertrophic cardiomyopathy, Cardiac imaging, Diagnostic imaging, Myocardial infarction, Pulse (Heart beat)
Abstract: Purpose: To propose and validate a cardiac T1ρ mapping sequence at 0.55 T comparing continuous‐wave and adiabatic spin‐lock (SL) preparation pulses. Methods: The proposed 2D sequence acquires four single‐shot balanced SSFP readout images with differing contrasts in a single breath‐hold. The first three images are prepared with T1ρ preparation pulses with different durations, while the last image uses a saturation pulse immediately before data acquisition. The T1ρ map is calculated using a 3‐parameter fitting method. Bloch equation simulations were performed to optimize the parameters of the adiabatic‐SL pulses. Phantom studies and in vivo experiments in 10 healthy volunteers, a porcine myocardial infarction model, and a patient with suspected hypertrophic cardiomyopathy were performed to validate the performance of the proposed adiabatic T1ρ (T1ρAd) mapping in comparison with conventional continuous‐wave T1ρ (T1ρCW) mapping. Results: The adiabatic‐SL pulse with simulation‐optimized parameters demonstrated robust performance despite B0 and B1 field inhomogeneities. Phantom T1ρCW and T1ρAd mapping exhibited comparable precision. In vivo experiments on healthy volunteers showed that myocardial T1ρAd is higher than T1ρCW (106.1 ± 7.1 vs. 47.0 ± 5.1 ms, p < 0.01) with better precision (11.4% ± 2.6% vs. 14.5% ± 2.1%, p < 0.01) and less spatial variation (10.9% ± 3.0% vs. 14.4% ± 3.4%, p < 0.01). Both T1ρCW and T1ρAd mapping agreed with late gadolinium enhancement findings in the porcine model and the patient, and exhibited improved contrast compared to T1 and T2 mapping. Conclusion: Both T1ρCW and T1ρAd are promising for non‐contrast detection of various cardiomyopathies at 0.55 T, but T1ρAd demonstrates better spatial uniformity than T1ρCW. [ABSTRACT FROM AUTHOR]
Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Initial experience of cardiac T&lt;subscript&gt;1&lt;/subscript&gt;ρ mapping at 0.55 T: Continuous wave versus adiabatic spin‐lock preparation pulses.
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Magnetic+Resonance+in+Medicine%22&quot;&gt;Magnetic Resonance in Medicine&lt;/searchLink&gt;. Oct2025, Vol. 94 Issue 4, p1644-1653. 10p.
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  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Hypertrophic+cardiomyopathy%22&quot;&gt;Hypertrophic cardiomyopathy&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Cardiac+imaging%22&quot;&gt;Cardiac imaging&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Diagnostic+imaging%22&quot;&gt;Diagnostic imaging&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Myocardial+infarction%22&quot;&gt;Myocardial infarction&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Pulse+%28Heart+beat%29%22&quot;&gt;Pulse (Heart beat)&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Purpose: To propose and validate a cardiac T1ρ mapping sequence at 0.55 T comparing continuous‐wave and adiabatic spin‐lock (SL) preparation pulses. Methods: The proposed 2D sequence acquires four single‐shot balanced SSFP readout images with differing contrasts in a single breath‐hold. The first three images are prepared with T1ρ preparation pulses with different durations, while the last image uses a saturation pulse immediately before data acquisition. The T1ρ map is calculated using a 3‐parameter fitting method. Bloch equation simulations were performed to optimize the parameters of the adiabatic‐SL pulses. Phantom studies and in vivo experiments in 10 healthy volunteers, a porcine myocardial infarction model, and a patient with suspected hypertrophic cardiomyopathy were performed to validate the performance of the proposed adiabatic T1ρ (T1ρAd) mapping in comparison with conventional continuous‐wave T1ρ (T1ρCW) mapping. Results: The adiabatic‐SL pulse with simulation‐optimized parameters demonstrated robust performance despite B0 and B1 field inhomogeneities. Phantom T1ρCW and T1ρAd mapping exhibited comparable precision. In vivo experiments on healthy volunteers showed that myocardial T1ρAd is higher than T1ρCW (106.1 &#177; 7.1 vs. 47.0 &#177; 5.1 ms, p &lt; 0.01) with better precision (11.4% &#177; 2.6% vs. 14.5% &#177; 2.1%, p &lt; 0.01) and less spatial variation (10.9% &#177; 3.0% vs. 14.4% &#177; 3.4%, p &lt; 0.01). Both T1ρCW and T1ρAd mapping agreed with late gadolinium enhancement findings in the porcine model and the patient, and exhibited improved contrast compared to T1 and T2 mapping. Conclusion: Both T1ρCW and T1ρAd are promising for non‐contrast detection of various cardiomyopathies at 0.55 T, but T1ρAd demonstrates better spatial uniformity than T1ρCW. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
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  Data: &lt;i&gt;Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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        Value: 10.1002/mrm.30582
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        Text: English
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        PageCount: 10
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    Subjects:
      – SubjectFull: Hypertrophic cardiomyopathy
        Type: general
      – SubjectFull: Cardiac imaging
        Type: general
      – SubjectFull: Diagnostic imaging
        Type: general
      – SubjectFull: Myocardial infarction
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      – SubjectFull: Pulse (Heart beat)
        Type: general
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      – TitleFull: Initial experience of cardiac T1ρ mapping at 0.55 T: Continuous wave versus adiabatic spin‐lock preparation pulses.
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              M: 10
              Text: Oct2025
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