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Comparison of physicochemical and biological properties of calcium phosphate cements incorporating different strontium-containing compounds.

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Title: Comparison of physicochemical and biological properties of calcium phosphate cements incorporating different strontium-containing compounds.
Authors: Yuan, Xinyuan1,2 (AUTHOR) yuan.xinyuan@mayo.edu, Wu, Tingting1,3 (AUTHOR), Lu, Teliang3 (AUTHOR), Ye, Jiandong1,2 (AUTHOR) jdye@scut.edu.cn
Source: Ceramics International. Dec2025:Part A, Vol. 51 Issue 29, p60094-60105. 12p.
Subjects: Strontium compounds, Bone regeneration, Chemical properties, Biochemistry, Stem cells, Calcium phosphate, Bone growth, Biomaterials
Abstract: Strontium (Sr) modified biomaterials are testified to be beneficial for bone regeneration. The form of Sr incorporated in calcium phosphate cement (CPC) plays a vital role in the ion release behavior and osteogenesis of cement. In this study, four kinds of Sr-containing compounds, SrCO 3 (SrC), SrHPO 4 (SrP), SrSiO 3 (SrSi) and SrSO 4 (SrS) were incorporated into CPC, respectively. The effects on the physicochemical and biological properties of Sr-CPCs were comparatively investigated. The results showed that all Sr-containing compounds shortened the setting time and increased the injectability of CPC. The phases of CPC changed a little and the hydrated crystals became thinner. All CPCs modified by Sr compounds could release Sr in a long-term behavior. Moreover, all Sr compounds significantly promoted the adhesion and proliferation behaviors of mouse bone marrow mesenchymal stem cells (mBMSCs) on the surface of CPC. Compared to CPC alone, cells cultured on CPC containing SrC and SrSi exhibited higher expression levels of osteogenic genes, including ALP, Runx2, OCN, OPN, Col-I, and BSP, than those on the other two CPCs containing Sr compounds. In addition, SrSi/CPC showed higher ALP activity. In summary, CPCs incorporated with SrCO 3 and SrSiO 3 demonstrated enhanced osteogenic performance. This finding is expected to provide a theoretical foundation and practical guideline for the development of Sr-modified calcium phosphate cements (CPCs) with optimized setting time, improved injectability, and enhanced osteogenic performance. [ABSTRACT FROM AUTHOR]
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Database: Engineering Source
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Abstract:Strontium (Sr) modified biomaterials are testified to be beneficial for bone regeneration. The form of Sr incorporated in calcium phosphate cement (CPC) plays a vital role in the ion release behavior and osteogenesis of cement. In this study, four kinds of Sr-containing compounds, SrCO 3 (SrC), SrHPO 4 (SrP), SrSiO 3 (SrSi) and SrSO 4 (SrS) were incorporated into CPC, respectively. The effects on the physicochemical and biological properties of Sr-CPCs were comparatively investigated. The results showed that all Sr-containing compounds shortened the setting time and increased the injectability of CPC. The phases of CPC changed a little and the hydrated crystals became thinner. All CPCs modified by Sr compounds could release Sr in a long-term behavior. Moreover, all Sr compounds significantly promoted the adhesion and proliferation behaviors of mouse bone marrow mesenchymal stem cells (mBMSCs) on the surface of CPC. Compared to CPC alone, cells cultured on CPC containing SrC and SrSi exhibited higher expression levels of osteogenic genes, including ALP, Runx2, OCN, OPN, Col-I, and BSP, than those on the other two CPCs containing Sr compounds. In addition, SrSi/CPC showed higher ALP activity. In summary, CPCs incorporated with SrCO 3 and SrSiO 3 demonstrated enhanced osteogenic performance. This finding is expected to provide a theoretical foundation and practical guideline for the development of Sr-modified calcium phosphate cements (CPCs) with optimized setting time, improved injectability, and enhanced osteogenic performance. [ABSTRACT FROM AUTHOR]
ISSN:02728842
DOI:10.1016/j.ceramint.2025.10.208