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Comparison of physicochemical and biological properties of calcium phosphate cements incorporating different strontium-containing compounds.

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Title: Comparison of physicochemical and biological properties of calcium phosphate cements incorporating different strontium-containing compounds.
Authors: Yuan, Xinyuan1,2 (AUTHOR) yuan.xinyuan@mayo.edu, Wu, Tingting1,3 (AUTHOR), Lu, Teliang3 (AUTHOR), Ye, Jiandong1,2 (AUTHOR) jdye@scut.edu.cn
Source: Ceramics International. Dec2025:Part A, Vol. 51 Issue 29, p60094-60105. 12p.
Subjects: Strontium compounds, Bone regeneration, Chemical properties, Biochemistry, Stem cells, Calcium phosphate, Bone growth, Biomaterials
Abstract: Strontium (Sr) modified biomaterials are testified to be beneficial for bone regeneration. The form of Sr incorporated in calcium phosphate cement (CPC) plays a vital role in the ion release behavior and osteogenesis of cement. In this study, four kinds of Sr-containing compounds, SrCO 3 (SrC), SrHPO 4 (SrP), SrSiO 3 (SrSi) and SrSO 4 (SrS) were incorporated into CPC, respectively. The effects on the physicochemical and biological properties of Sr-CPCs were comparatively investigated. The results showed that all Sr-containing compounds shortened the setting time and increased the injectability of CPC. The phases of CPC changed a little and the hydrated crystals became thinner. All CPCs modified by Sr compounds could release Sr in a long-term behavior. Moreover, all Sr compounds significantly promoted the adhesion and proliferation behaviors of mouse bone marrow mesenchymal stem cells (mBMSCs) on the surface of CPC. Compared to CPC alone, cells cultured on CPC containing SrC and SrSi exhibited higher expression levels of osteogenic genes, including ALP, Runx2, OCN, OPN, Col-I, and BSP, than those on the other two CPCs containing Sr compounds. In addition, SrSi/CPC showed higher ALP activity. In summary, CPCs incorporated with SrCO 3 and SrSiO 3 demonstrated enhanced osteogenic performance. This finding is expected to provide a theoretical foundation and practical guideline for the development of Sr-modified calcium phosphate cements (CPCs) with optimized setting time, improved injectability, and enhanced osteogenic performance. [ABSTRACT FROM AUTHOR]
Copyright of Ceramics International is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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DbLabel: Engineering Source
An: 189413628
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  Label: Title
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  Data: Comparison of physicochemical and biological properties of calcium phosphate cements incorporating different strontium-containing compounds.
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  Data: <searchLink fieldCode="AR" term="%22Yuan%2C+Xinyuan%22">Yuan, Xinyuan</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> yuan.xinyuan@mayo.edu</i><br /><searchLink fieldCode="AR" term="%22Wu%2C+Tingting%22">Wu, Tingting</searchLink><relatesTo>1,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lu%2C+Teliang%22">Lu, Teliang</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ye%2C+Jiandong%22">Ye, Jiandong</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> jdye@scut.edu.cn</i>
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  Data: <searchLink fieldCode="JN" term="%22Ceramics+International%22">Ceramics International</searchLink>. Dec2025:Part A, Vol. 51 Issue 29, p60094-60105. 12p.
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  Data: <searchLink fieldCode="DE" term="%22Strontium+compounds%22">Strontium compounds</searchLink><br /><searchLink fieldCode="DE" term="%22Bone+regeneration%22">Bone regeneration</searchLink><br /><searchLink fieldCode="DE" term="%22Chemical+properties%22">Chemical properties</searchLink><br /><searchLink fieldCode="DE" term="%22Biochemistry%22">Biochemistry</searchLink><br /><searchLink fieldCode="DE" term="%22Stem+cells%22">Stem cells</searchLink><br /><searchLink fieldCode="DE" term="%22Calcium+phosphate%22">Calcium phosphate</searchLink><br /><searchLink fieldCode="DE" term="%22Bone+growth%22">Bone growth</searchLink><br /><searchLink fieldCode="DE" term="%22Biomaterials%22">Biomaterials</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Strontium (Sr) modified biomaterials are testified to be beneficial for bone regeneration. The form of Sr incorporated in calcium phosphate cement (CPC) plays a vital role in the ion release behavior and osteogenesis of cement. In this study, four kinds of Sr-containing compounds, SrCO 3 (SrC), SrHPO 4 (SrP), SrSiO 3 (SrSi) and SrSO 4 (SrS) were incorporated into CPC, respectively. The effects on the physicochemical and biological properties of Sr-CPCs were comparatively investigated. The results showed that all Sr-containing compounds shortened the setting time and increased the injectability of CPC. The phases of CPC changed a little and the hydrated crystals became thinner. All CPCs modified by Sr compounds could release Sr in a long-term behavior. Moreover, all Sr compounds significantly promoted the adhesion and proliferation behaviors of mouse bone marrow mesenchymal stem cells (mBMSCs) on the surface of CPC. Compared to CPC alone, cells cultured on CPC containing SrC and SrSi exhibited higher expression levels of osteogenic genes, including ALP, Runx2, OCN, OPN, Col-I, and BSP, than those on the other two CPCs containing Sr compounds. In addition, SrSi/CPC showed higher ALP activity. In summary, CPCs incorporated with SrCO 3 and SrSiO 3 demonstrated enhanced osteogenic performance. This finding is expected to provide a theoretical foundation and practical guideline for the development of Sr-modified calcium phosphate cements (CPCs) with optimized setting time, improved injectability, and enhanced osteogenic performance. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Ceramics International is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1016/j.ceramint.2025.10.208
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      – Code: eng
        Text: English
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      Pagination:
        PageCount: 12
        StartPage: 60094
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        Type: general
      – SubjectFull: Bone regeneration
        Type: general
      – SubjectFull: Chemical properties
        Type: general
      – SubjectFull: Biochemistry
        Type: general
      – SubjectFull: Stem cells
        Type: general
      – SubjectFull: Calcium phosphate
        Type: general
      – SubjectFull: Bone growth
        Type: general
      – SubjectFull: Biomaterials
        Type: general
    Titles:
      – TitleFull: Comparison of physicochemical and biological properties of calcium phosphate cements incorporating different strontium-containing compounds.
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            NameFull: Yuan, Xinyuan
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            NameFull: Wu, Tingting
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            NameFull: Lu, Teliang
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            NameFull: Ye, Jiandong
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            – D: 01
              M: 12
              Text: Dec2025:Part A
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              Y: 2025
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