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Rare and underexplored lobane- and prenyleudesmane-type diterpenes primarily from corals with additional plant sources—Biosynthesis and pharmacological perspectives.

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Title: Rare and underexplored lobane- and prenyleudesmane-type diterpenes primarily from corals with additional plant sources—Biosynthesis and pharmacological perspectives.
Authors: Chen, Lo-Yun1 (AUTHOR), Peng, Bo-Rong1,2,3,4 (AUTHOR), Chen, You-Ying5,6 (AUTHOR), Le, Huong-Giang7 (AUTHOR), Pham, Ngoc-Thac1 (AUTHOR), Lin, Yi-Ying2 (AUTHOR), Chen, Hung-Yi2,8 (AUTHOR), Hsieh, Pei-Jhen2 (AUTHOR), El-Shazly, Mohamed9 (AUTHOR), Lai, Kuei-Hung1,2,8,10 (AUTHOR) kueihunglai@tmu.edu.tw
Source: Phytochemistry. Feb2026, Vol. 242, pN.PAG-N.PAG. 1p.
Subjects: Diterpenes, Biosynthesis, Drug discovery, Corals, Anti-inflammatory agents, Pharmacology
Abstract: Lobane- and prenyleudesmane-type diterpenoids represent structurally unique and biologically diverse natural products, predominantly isolated from soft corals in the genera Lobophytum and Sinularia. This review comprehensively covers the literature from 1978 to 2025, isolation methods, structural elucidation, biological evaluations, and proposed biosynthetic pathways. Based on their reported bioactivities, the compounds were systematically classified, and their potential biosynthetic pathways were proposed. Additionally, a structure–activity relationship (SAR) analysis was conducted to further elucidate the functional groups responsible for their anti-inflammatory, toxicity and anti-fungal properties. To address the challenge of insufficient supply for biological assays, recent total syntheses of representative compounds were also highlighted, providing alternative solutions for future drug discovery and mechanistic studies. This review not only consolidates current knowledge but also provides perspectives for future biosynthetic studies and the development of marine-derived diterpenoids as therapeutic leads. Overview of marine-derived lobane- and prenyleudesmane-type diterpenoids reported from 1978 to 2025, highlighting key functional groups linked to anti-inflammatory and toxicity activities, proposed biosynthetic pathways for these rare skeletons, and the therapeutic potential of fuscoside derivatives through 5-LOX inhibition. [Display omitted] • Reviewed marine-derived lobane and prenyleudesmane diterpenoids (1978–2025). • SAR analysis revealed key groups linked to anti-inflammatory and toxicity effects. • Proposed plausible biosynthetic routes for rare marine diterpenoid skeletons. • Fuscoside derivatives inhibit 5-LOX showing drug development value. [ABSTRACT FROM AUTHOR]
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Database: Engineering Source
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Abstract:Lobane- and prenyleudesmane-type diterpenoids represent structurally unique and biologically diverse natural products, predominantly isolated from soft corals in the genera Lobophytum and Sinularia. This review comprehensively covers the literature from 1978 to 2025, isolation methods, structural elucidation, biological evaluations, and proposed biosynthetic pathways. Based on their reported bioactivities, the compounds were systematically classified, and their potential biosynthetic pathways were proposed. Additionally, a structure–activity relationship (SAR) analysis was conducted to further elucidate the functional groups responsible for their anti-inflammatory, toxicity and anti-fungal properties. To address the challenge of insufficient supply for biological assays, recent total syntheses of representative compounds were also highlighted, providing alternative solutions for future drug discovery and mechanistic studies. This review not only consolidates current knowledge but also provides perspectives for future biosynthetic studies and the development of marine-derived diterpenoids as therapeutic leads. Overview of marine-derived lobane- and prenyleudesmane-type diterpenoids reported from 1978 to 2025, highlighting key functional groups linked to anti-inflammatory and toxicity activities, proposed biosynthetic pathways for these rare skeletons, and the therapeutic potential of fuscoside derivatives through 5-LOX inhibition. [Display omitted] • Reviewed marine-derived lobane and prenyleudesmane diterpenoids (1978–2025). • SAR analysis revealed key groups linked to anti-inflammatory and toxicity effects. • Proposed plausible biosynthetic routes for rare marine diterpenoid skeletons. • Fuscoside derivatives inhibit 5-LOX showing drug development value. [ABSTRACT FROM AUTHOR]
ISSN:00319422
DOI:10.1016/j.phytochem.2025.114717