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Mixed micellar liquid chromatography with polyoxyethylene(10)tridecyl ether and sodium dodecyl sulphate: An organic solvent-free approach.

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Title: Mixed micellar liquid chromatography with polyoxyethylene(10)tridecyl ether and sodium dodecyl sulphate: An organic solvent-free approach.
Authors: Cuenca-Serrano, C.1 (AUTHOR), Peris-Vicente, J.1 (AUTHOR), García-Alvarez-Coque, M.C.1 (AUTHOR), Ruiz-Angel, M.J.1 (AUTHOR) maria.j.ruiz@uv.es
Source: Microchemical Journal. Dec2025, Vol. 219, pN.PAG-N.PAG. 1p.
Subjects: Micellar liquid chromatography, Sodium dodecyl sulfate, Sustainable chemistry, Nonionic surfactants, Surface active agents, Chromatographic analysis, High performance liquid chromatography, Pharmaceutical chemistry
Abstract: This work explores the behaviour of the non-ionic surfactant polyoxyethylene(10)tridecyl ether (C13E10) in micellar liquid chromatography, both individually and in combination with the anionic surfactant sodium dodecyl sulphate (SDS), for the separation of β-adrenoceptor antagonists. Despite its favourable physicochemical properties, particularly its shorter polyoxyethylene chain compared to the widely used non-ionic surfactant Brij-35, C13E10 has received considerably less attention. Particular emphasis is placed on column conditioning and surfactant desorption to ensure the reproducibility of the method. The retention behaviour of the analytes is systematically investigated across a range of C13E10 concentrations, both in the absence and presence of SDS. A three-phase model is applied to estimate the solute-stationary phase and solute-micelle association constants to obtain deeper insights into the underlying retention mechanisms. The incorporation of SDS into the C13E10 system markedly improved selectivity, resolution, and peak symmetry, as demonstrated by experimental chromatograms and peak shape analysis. The C13E10/SDS mixed micellar system enhances analytical performance while eliminating the need for organic solvents, offering a more sustainable alternative to conventional reversed-phase liquid chromatography. Beyond improving chromatographic performance, this approach aligns with the principles of green chemistry, offering an efficient and environmentally friendly platform for the analysis of basic pharmaceutical compounds. [Display omitted] • Polyoxyethylene(10)tridecyl ether is applied in micellar liquid chromatography • Stable performance with good reproducibility and reversible surfactant adsorption • Mixed non-ionic/anionic mobile phases enable fine-tuned retention of basic compounds • Organic solvent consumption is eliminated, enhancing greenness [ABSTRACT FROM AUTHOR]
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Database: Engineering Source
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Abstract:This work explores the behaviour of the non-ionic surfactant polyoxyethylene(10)tridecyl ether (C13E10) in micellar liquid chromatography, both individually and in combination with the anionic surfactant sodium dodecyl sulphate (SDS), for the separation of β-adrenoceptor antagonists. Despite its favourable physicochemical properties, particularly its shorter polyoxyethylene chain compared to the widely used non-ionic surfactant Brij-35, C13E10 has received considerably less attention. Particular emphasis is placed on column conditioning and surfactant desorption to ensure the reproducibility of the method. The retention behaviour of the analytes is systematically investigated across a range of C13E10 concentrations, both in the absence and presence of SDS. A three-phase model is applied to estimate the solute-stationary phase and solute-micelle association constants to obtain deeper insights into the underlying retention mechanisms. The incorporation of SDS into the C13E10 system markedly improved selectivity, resolution, and peak symmetry, as demonstrated by experimental chromatograms and peak shape analysis. The C13E10/SDS mixed micellar system enhances analytical performance while eliminating the need for organic solvents, offering a more sustainable alternative to conventional reversed-phase liquid chromatography. Beyond improving chromatographic performance, this approach aligns with the principles of green chemistry, offering an efficient and environmentally friendly platform for the analysis of basic pharmaceutical compounds. [Display omitted] • Polyoxyethylene(10)tridecyl ether is applied in micellar liquid chromatography • Stable performance with good reproducibility and reversible surfactant adsorption • Mixed non-ionic/anionic mobile phases enable fine-tuned retention of basic compounds • Organic solvent consumption is eliminated, enhancing greenness [ABSTRACT FROM AUTHOR]
ISSN:0026265X
DOI:10.1016/j.microc.2025.115954