Alternating magnetic field and induction heating as antibacterial therapy in implant-associated infections.
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| Title: | Alternating magnetic field and induction heating as antibacterial therapy in implant-associated infections. |
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| Authors: | Irmak Šalandová, Monika1 (AUTHOR) m.salandova@tudelft.nl, Fratila-Apachitei, Lidy E.1 (AUTHOR), Apachitei, Iulian1 (AUTHOR) i.apachitei@tudelft.nl, Zadpoor, Amir A.1,2 (AUTHOR) |
| Source: | International Journal of Hyperthermia. Dec2025, Vol. 42 Issue 1, p1-24. 24p. |
| Subjects: | Induction heating, Biofilms, Treatment effectiveness, Thermotherapy, Wounds & injuries, Prosthesis-related infections, Drug resistance in bacteria, Magnetic fields |
| Abstract: | Objective: The treatment of mature biofilm in implant-associated infections (IAI) has become increasingly challenging, mainly due to the rise of antibiotic-resistant bacteria. While many antibacterial biomaterials harness their functionality through their surface properties, alternating magnetic field (AMF)-induced hyperthermia offers an approach from a fundamentally different angle. Method: To summarize and compare the practice of assessing AMF-induced hyperthermia in vitro and in vivo as treatment for implant-associated infections and the efficacy of this therapy, a literature search was conducted and 18 articles were selected based on relevance. Results and conclusion: The studies have demonstrated that AMF-induced hyperthermia can effectively eliminate biofilms as a standalone treatment or in combination with antimicrobials. Although thermal tissue damage is an inherent concern, it can be controlled and reduced by implementing short intermittent heating patterns around 65–75ºC while still preserving antibacterial efficacy. However, clear guidelines for evaluating safety, particularly regarding thermal injury, are still lacking and should be a key focus of future work. [ABSTRACT FROM AUTHOR] |
| Copyright of International Journal of Hyperthermia is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
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| Abstract: | Objective: The treatment of mature biofilm in implant-associated infections (IAI) has become increasingly challenging, mainly due to the rise of antibiotic-resistant bacteria. While many antibacterial biomaterials harness their functionality through their surface properties, alternating magnetic field (AMF)-induced hyperthermia offers an approach from a fundamentally different angle. Method: To summarize and compare the practice of assessing AMF-induced hyperthermia in vitro and in vivo as treatment for implant-associated infections and the efficacy of this therapy, a literature search was conducted and 18 articles were selected based on relevance. Results and conclusion: The studies have demonstrated that AMF-induced hyperthermia can effectively eliminate biofilms as a standalone treatment or in combination with antimicrobials. Although thermal tissue damage is an inherent concern, it can be controlled and reduced by implementing short intermittent heating patterns around 65–75ºC while still preserving antibacterial efficacy. However, clear guidelines for evaluating safety, particularly regarding thermal injury, are still lacking and should be a key focus of future work. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 02656736 |
| DOI: | 10.1080/02656736.2025.2563301 |
