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The synthesis of Fe3O4@Au nanoparticles and the feasibility study of attaching them to the E. coli bacterial membrane.

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Title: The synthesis of Fe3O4@Au nanoparticles and the feasibility study of attaching them to the E. coli bacterial membrane.
Authors: Alavi, F.1 (AUTHOR) Fatemehalavi.bio96@gmail.com, Saievar-Iranizad, E.1 (AUTHOR) saievare@modares.ac.ir, Mohammadi, Sh Roudbar2 (AUTHOR) sh.mohammadi@modares.ac.ir
Source: Materials Chemistry & Physics. Mar2026, Vol. 351, pN.PAG-N.PAG. 1p.
Subjects: Iron oxide nanoparticles, Escherichia coli, Bacterial cell walls, Coprecipitation (Chemistry), Nanomedicine, Chemical synthesis, Magnetic fields, Biocompatibility
Abstract: This study focuses on the feasibility study of attaching Fe 3 O 4 @Au nanoparticles (NPs) to the membrane of Escherichia coli (E. coli) bacteria. Among various NPs, Fe 3 O 4 nanoparticles were selected due to their high magnetic saturation. These NPs were synthesized with an average size of 16 nm using a co-precipitation method, and their saturation magnetization was 80 emu/g. To prevent aggregation and oxidation of the Fe 3 O 4 nanoparticles and to stabilize them, it was necessary to coat the nanoparticles. Among different metals, gold was chosen due to its high chemical stability, biocompatibility and non-toxic nature. Subsequently, the coating of Fe 3 O 4 @Au nanoparticles was carried out using a chemical reduction method with oleic amine and ascorbic acid as reducing agents. The resulting Fe 3 O 4 @Au nanoparticles had an average size of about 20 nm and a saturation magnetization of 60 emu/g. E. coli bacteria from a urine sample were cultured in MacConkey agar medium. Then, the optimal concentration of Fe 3 O 4 @Au nanoparticles (8 mg/L) was injected into the bacterial culture and subjected to TEM analysis. This study successfully demonstrated the attachment of Fe 3 O 4 @Au nanoparticles to the membrane of E. coli bacteria. Furthermore, the attached bacteria to the nanoparticles exhibited successful responses to an external magnetic field. The movement of E. coli bacteria in the magnetic field suggests that there are potential applications in targeted bacterial and cancer therapy. [Display omitted] • Fe 3 O 4 nanoparticles were synthesized with a size of about 16 nm. • Fe 3 O 4 @Au nanoparticles were synthesized with an average size of 20 nm. • Fe 3 O 4 @Au nanoparticles were successfully attached to E. coli bacteria membrane. • Bacteria-attached nanoparticles uniquely responded to an external magnetic field. [ABSTRACT FROM AUTHOR]
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Database: Engineering Source
Description
Abstract:This study focuses on the feasibility study of attaching Fe 3 O 4 @Au nanoparticles (NPs) to the membrane of Escherichia coli (E. coli) bacteria. Among various NPs, Fe 3 O 4 nanoparticles were selected due to their high magnetic saturation. These NPs were synthesized with an average size of 16 nm using a co-precipitation method, and their saturation magnetization was 80 emu/g. To prevent aggregation and oxidation of the Fe 3 O 4 nanoparticles and to stabilize them, it was necessary to coat the nanoparticles. Among different metals, gold was chosen due to its high chemical stability, biocompatibility and non-toxic nature. Subsequently, the coating of Fe 3 O 4 @Au nanoparticles was carried out using a chemical reduction method with oleic amine and ascorbic acid as reducing agents. The resulting Fe 3 O 4 @Au nanoparticles had an average size of about 20 nm and a saturation magnetization of 60 emu/g. E. coli bacteria from a urine sample were cultured in MacConkey agar medium. Then, the optimal concentration of Fe 3 O 4 @Au nanoparticles (8 mg/L) was injected into the bacterial culture and subjected to TEM analysis. This study successfully demonstrated the attachment of Fe 3 O 4 @Au nanoparticles to the membrane of E. coli bacteria. Furthermore, the attached bacteria to the nanoparticles exhibited successful responses to an external magnetic field. The movement of E. coli bacteria in the magnetic field suggests that there are potential applications in targeted bacterial and cancer therapy. [Display omitted] • Fe 3 O 4 nanoparticles were synthesized with a size of about 16 nm. • Fe 3 O 4 @Au nanoparticles were synthesized with an average size of 20 nm. • Fe 3 O 4 @Au nanoparticles were successfully attached to E. coli bacteria membrane. • Bacteria-attached nanoparticles uniquely responded to an external magnetic field. [ABSTRACT FROM AUTHOR]
ISSN:02540584
DOI:10.1016/j.matchemphys.2025.131932