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Catechol-based zwitterionic polymers with antibacterial and antifouling properties for biomedical surface coatings.

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Title: Catechol-based zwitterionic polymers with antibacterial and antifouling properties for biomedical surface coatings.
Authors: Hou, Shan-Wei1 (AUTHOR), Chang, Jui-Jen2,3 (AUTHOR), Lin, Li-Ying1 (AUTHOR), Pham, Uyen Khanh1 (AUTHOR), Do, Thi Thu Ha1 (AUTHOR), Lee, Cheng-Kang1 (AUTHOR), Hsiao, Wesley Wei-Wen1 (AUTHOR) weshsiao@mail.ntust.edu.tw
Source: Progress in Organic Coatings. Apr2026, Vol. 213, pN.PAG-N.PAG. 1p.
Subjects: Antibacterial agents, Biofilms, Functional groups, Polyethylene glycol, Surface preparation, Biocides, Polyzwitterions
Abstract: Persistent biofilms on medical device surfaces account for up to 80 % of chronic clinical infections, posing a major challenge to infection control and patient safety. To overcome this limitation, a zwitterionic polymer–PEGDGE-TAU-CCDP (PTC), was synthesized using polyethylene glycol diglycidyl ether (PEGDGE), taurine (TAU), and 2-chloro-3′,4′-dihydroxyacetophenone (CCDP). The incorporation of catechol functionalities enabled the polymer with redox activity under aerobic and ion-rich environments, a property previously associated with antibacterial behavior in catechol-based systems. Ultraviolet–visible (UV–Vis), Fourier-transform infrared (FTIR), and proton nuclear magnetic resonance (1H NMR) spectroscopy confirmed the successful synthesis and catechol incorporation. Quantitative analysis revealed a CCDP grafting efficiency of approximately 29 %. Notably, the addition of ε-Polylysine (EPL) enhanced coating adhesion to various substrates without compromising the intrinsic antibacterial activity of the material. Bacterial growth curves, minimum inhibitory concentration (MIC), and minimum bactericidal concentration (MBC) assays demonstrated that EPL/PTC had an MIC of 0.31 mg/mL and an MBC of 1.25 mg/mL. Furthermore, the EPL/PTC-coated silicone rubber exhibited approximately 85 % biofilm inhibition and 76 % antifouling efficiency. By combining antifouling and antibacterial properties within a single system, this strategy achieves multifunctional performance that is rarely observed in conventional surface treatments. These findings highlight EPL/PTC as a promising candidate for reducing surface fouling and infection risks, thereby supporting its potential application in developing safer biomedical device materials. [Display omitted] • Cross-contamination remains a major challenge in medical device sterilization. • A novel zwitterionic polymer, PEGDGE-TAU-CCDP (PTC), exhibits strong antioxidant, antibacterial, and antifouling properties. • Incorporating ε-Polylysine (EPL) yields a hybrid coating (EPL/PTC) that reduces cross-contamination and helps prevent infections. • The coating is hydrophilic, highly antibacterial, and inhibits biofilm formation by up to 90%. • Enhanced adhesion, reduced tensile stress, and decreased cracking make it promising for medical applications. [ABSTRACT FROM AUTHOR]
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Database: Engineering Source
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Abstract:Persistent biofilms on medical device surfaces account for up to 80 % of chronic clinical infections, posing a major challenge to infection control and patient safety. To overcome this limitation, a zwitterionic polymer–PEGDGE-TAU-CCDP (PTC), was synthesized using polyethylene glycol diglycidyl ether (PEGDGE), taurine (TAU), and 2-chloro-3′,4′-dihydroxyacetophenone (CCDP). The incorporation of catechol functionalities enabled the polymer with redox activity under aerobic and ion-rich environments, a property previously associated with antibacterial behavior in catechol-based systems. Ultraviolet–visible (UV–Vis), Fourier-transform infrared (FTIR), and proton nuclear magnetic resonance (1H NMR) spectroscopy confirmed the successful synthesis and catechol incorporation. Quantitative analysis revealed a CCDP grafting efficiency of approximately 29 %. Notably, the addition of ε-Polylysine (EPL) enhanced coating adhesion to various substrates without compromising the intrinsic antibacterial activity of the material. Bacterial growth curves, minimum inhibitory concentration (MIC), and minimum bactericidal concentration (MBC) assays demonstrated that EPL/PTC had an MIC of 0.31 mg/mL and an MBC of 1.25 mg/mL. Furthermore, the EPL/PTC-coated silicone rubber exhibited approximately 85 % biofilm inhibition and 76 % antifouling efficiency. By combining antifouling and antibacterial properties within a single system, this strategy achieves multifunctional performance that is rarely observed in conventional surface treatments. These findings highlight EPL/PTC as a promising candidate for reducing surface fouling and infection risks, thereby supporting its potential application in developing safer biomedical device materials. [Display omitted] • Cross-contamination remains a major challenge in medical device sterilization. • A novel zwitterionic polymer, PEGDGE-TAU-CCDP (PTC), exhibits strong antioxidant, antibacterial, and antifouling properties. • Incorporating ε-Polylysine (EPL) yields a hybrid coating (EPL/PTC) that reduces cross-contamination and helps prevent infections. • The coating is hydrophilic, highly antibacterial, and inhibits biofilm formation by up to 90%. • Enhanced adhesion, reduced tensile stress, and decreased cracking make it promising for medical applications. [ABSTRACT FROM AUTHOR]
ISSN:03009440
DOI:10.1016/j.porgcoat.2025.109915